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All Journal Jurnal Forum Nuklir Urania: Jurnal Ilmiah Daur Bahan Bakar Nuklir
Yayan Tahyan
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Materials Science & Nanotechnology

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VALIDASI PENGUKURAN OSMOLALITAS DENGAN MENGGUNAKAN LARUTAN STANDAR PADA ALAT AUTOMATIC OSMOMETER Amal Rezka Putra; Maskur Maskur; Yayan Tahyan
Jurnal Forum Nuklir JFN Vol 10 No 2 November 2016
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.411 KB) | DOI: 10.17146/jfn.2016.10.2.3497

Abstract

VALIDASI PENGUKURAN OSMOLALITAS DENGAN MENGGUNAKAN LARUTAN STANDAR PADA ALAT AUTOMATIC OSMOMETER. Salah satu syarat sediaan farmasi khususnya sediaan injeksi intravena yaitu penentuan nilai osmolalitas. Alat yang digunakan untuk menentukan nilai osmolalitas yaitu automatic osmometer. Sebelum digunakan secara rutin untuk menentukan osmolalitas sediaan radiofarmaka, diperlukan validasi terhadap alat automatic osmometer yaitu untuk memastikan apakah hasil pengukuran alat tersebut valid atau tidak. Validasi pengukuran osmometer dilakukan dengan tiga parameter yaitu akurasi, presisi, dan  linieritas. Sebagai  obyek pengukuran diambil larutan standar 100 mOsm/kg, 290 mOsm/kg, dan 500 mOsm/kg yang masing-masing diukur sebanyak 20 kali  dan dibuat tabel akurasi, grafik presisi, dan grafik linieritas. Prosentase akurasi pada standar 100 mOsm/kg=100,05%, 290 mOsm/kg=100,05% dan 500 mOsm/kg =100,42%. Validasi presisi pengukuran standar 100mOsm/kg menunjukkan nilai ±1SD=50%, ±2SD=50%, standar 290 mOsm/kg ±1SD=80%, ±2SD=15%, dan ±3SD=5%, dan standar 500 mOsm/kg  ±1SD=75%, ±2SD=25%. Nilai linieritas pada rerata hasil pengukuran yaitu a = 1,00520, b = 0,77533 dan r2  = 0,99999. Dari hasil validasi pengukuran nilai osmolalitas larutan standar dengan  alat  automatic  osmometer  dinyatakan  alat  tersebut  valid  untuk  digunakan  dalam  pengukuran osmolalitas sediaan radiofarmaka.
PENENTUAN KEMURNIAN RADIOKIMIA 99mTc-MIBI SECARA CEPAT DAN PRAKTIS MENGGUNAKAN DOSE CALIBRATOR Maskur Maskur; Enny Lestari; Endang Sarmini; Yayan Tahyan; Amal Rezka Putra; Dede Kurniasih; Adang Hardi Gunawan
Urania: Jurnal Ilmiah Daur Bahan Bakar Nuklir Vol. 23 No. 1 (2017): Urania : Jurnal Ilmiah Daur Bahan Bakar Nuklir
Publisher : Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/urania.2017.23.1.3195

Abstract

Generally, the determination of radiochemical purity begins with Radiochemical separation using thin layer chromatography (TLC), and then measurement using a gamma counter, but this method cannot be applied in hospitals since there is only a dose calibrator available in the hospitals. Therefore, we conducted such an investigation using an alternative method which is more practical and faster, ie begins with radiochemical separation using extraction method, and then measurement using a dose calibrator. The determination was carried out in which 99mTc-MIBI was extracted using a mixture of saline and chloroform with volume ratio of 1:1, the mixture was then extracted. The 99mTc - MIBI was in organic phase (chloroform), whereas 99mTcO2 and 99mTcO4- were both in water phase (saline). Then, each phase of the sample was taken with the same volume, and then the radioactivity was measured using a gamma ionization chamber and the radiochemical purity was calculated. Radiochemical purity with extraction process method Compared measuring using standard methods of TLC Furthermore, the results of the extraction were compared with the standard method of TDC. The results showed that the radiochemical purity of 99mTc-MIBI using the two methods were almost the same, ie =98.34 % ± 0, 65 % for TLC standard method and = 97.15 % ± 0,56 % for extraction method with good measurement precision. The time of determination for extraction method was 20 minutes and 180 minutes for TLC standard method respectively. These results indicated that the extraction method can be used as an alternative method for determination of radiochemical purity of 99mTc-MIBI radiopharmaceutical. The advantage of extraction method that it is faster compared to the TLC Method.
Co-Authors Adang Hardi Gunawan Amal Rezka Putra Amal Rezka Putra Dede Kurniasih Endang Sarmini Enny Lestari Maskur Maskur