<![CDATA[Introduction: Drugs trafficking (narcotics, psychotropic and other additives) presents a huge problem in many countries, including in Indonesia. Around 500,000 drug users in Central Java, 22 percent consist of students and college students. The lack of knowldege about its effects and consequences is the major reason of drug abuse. Providing sufficient knowledge of drug abuse will affect someones health behaviour, doing preventive actions should decrease the percentage and possibility of drug abuse .This research aimed to determine the relationship between drug abuse prevention with knowledge of a student. Methods: This research was an analytic observational with cross-sectional design. Subject were 83 tenth grader at SMA Negeri 3 Semarang. There were two variables in this research, knowledge as independent variable and preventive action as dependent variable. Knowledge and drug prevention were measured by questionnaires. Data were analyzed using chi square test. Result: From the result, 23 students (59.0%) were deficient in both knowledge and preventive action. 16 students (41.0%) were deficient in knowledge, sufficient in preventive action. 29 students (65.9%) were sufficient in both knowldege and preventive action. 15 students (34.1%) were sufficient in knowledge, deficient in preventive action. This research showed that there was significant relationship between the knowledge about drugs and drug abuse prevention among tenth grade student of SMA Negeri 3 Semarang, with p value = 0.023. Conclusion: There was a significant relationship between knowledge about drugs and drug abuse prevention among tenth grade students of SMA Negeri 3 Semarang. Keyword: Knowledge about drugs, prevention of drug abuse, high school students]]>
