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. Marwoto
Faculty of Medicine, Sebelas Maret University
Biochemistry, Genetics & Molecular Biology

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Skrining Methicillin Resistant Staphylococcus aureus (MRSA) pada Tenaga Kesehatan Bangsal Melati 1, Melati 2, dan Mawar 2 RSUD Dr. Moewardi Achmad Faiz Sulaiman; . Marwoto; . Purwoko
Nexus Biomedika Vol 2, No 2 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: MRSA is known as one of main cause of nosocomial infection since found in 1961. In Indonesia, its prevalence reached 23,5%. Direct contact to healthcare workers can cause transmission of Staphylococcus aureus to patients. Carrier of chronic MRSA plays important roles on MRSA infection in hospital setting. This research aimed to know the incidence of MRSA nasal carriage of healthcare workers in RSUD Dr Moewardi Surakarta. Methods: This was an descriptive study using cross sectional design. Samples were taken from nasal swab of healtcare workers in wards of Melati 1, Melati 2 and Mawar 2. Samples were examined in Microbiology Laboratory of FK UNS. Total samples obtained were 74 according to total sampling theory. Data were analyzed descriptively and tested with Chi-Square tests. Results: The result of nasal swab from 26 healthcare workers in Melati 1 ward showed that there were 7 healthcare workers that were colonized by Staphylococcus aureus and one of them was MRSA case. In Melati 2 ward, from 25 healthcare workers, ten of them were colonized by Staphylococcus aureus and 8 out of 10 healthcare workers were MRSA cases. Whereas in Mawar 2 ward from nasal swab of 23 healthcare workers, six of them were colonized by Staphylococcus aureus and no MRSA case was found. Conclusions: The number of MRSA incidence in Melati 1, Melati 2 and Mawar 2 wards consecutively were 1.33%, 10.67% and 0%. Keywords: MRSA, healthcare worker, colonization.
Interferon Gamma of Multidrug-resistant Tuberculosis (MDR-TB) Patients in Dr. Moewardi Hospital in Surakarta Hanif Hary Setyawan; . Hudiyono; . Marwoto; Afiono Agung Prasetyo
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Interferon-? (IFN-?) produced by CD4+(Th1) T cells plays a critical role in immunityto tuberculosis infection. MDR-TB patients have decreased T cell IFN-?production capacity. Data of IFN-? plasma level of MDR-TB patients in Indonesia, include its association with age and gender, are not yet known. This study was aimed to identify the profile of IFN-? on plasma of MDR-TB patients in Dr. Moewardi Hospital in Surakarta and its association with age and gender. Methods: Blood samples and medical records data from 43 MDR-TB patients in Dr. Moewardi Hospital in Surakarta were collected. Enzyme-linked immunosorbent assay (ELISA) serological test was done to measure IFN-?titer. Results: Twenty samples (46.5%, 20/43) had elevated IFN-? level in their plasma. Elevated IFN-? level was more likely to be found in women (OR 3.63; 95% CI 1.02-12.94) and respondentsaged 21-30 years (OR 4.5; 95% CI 0.79-25.57). No association between elevation of IFN-? level with age (p = 0.450) and gender (p = 0.067). Conclusions: Elevated IFN-? level was found in 46.5% of MDR-TB patients in Dr. Moewardi Hospital in Surakarta.Elevated IFN-? level was more likely to be found in women and respondents aged 21-30 years. Keywords: IFN-g, MDR-TB, Surakarta
Co-Authors . Hudiyono . Purwoko Achmad Faiz Sulaiman Afiono Agung Prasetyo Hanif Hary Setyawan