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Hideo Hayashi
Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan
Control & Systems Engineering Mathematics

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An Isoflovonoid, Warangalone from the Stem Bark of Dadap Ayam (Erythrina variegata) Tati Herlina; Nasrudin Nasrudin; Unang Supratman; Anas Subarnas; Supriyatna Sutardjo; Hideo Hayashi
Jurnal ILMU DASAR Vol 9 No 1 (2008)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

In the course of our continuing search for novel paralytic compound from Indonesian plants, the methanol extract of the stem bark of Erythrina variegata (Leguminosae) showed significant paralytic activity against the third instar larvae of silkworm (Bombyx mori). The purposes of this research were isolation and structural elucidation of paralytic compound from the stem bark of E. variegata. Using the paralytic activity following the separation, the methanol extract was separated by combination of column chromatography to yield prenylisoflavone, warangalone. The chemical structure of warangalone was identified based on spectroscopic evidence and comparison with the previous reported. The paralytic activity of warangalone showed weak activity against the third instar larvae of silkworm (B. mori).
Triterpenoid Pentacyclic Antimalarial Activity from the Leaves of Erythrina variegata Tati Herlina; Unang Supratman; Anas Urbanas; Supriyatna Sutardjo; Noor Rain Abdullah; Hideo Hayashi
Jurnal ILMU DASAR Vol 12 No 2 (2011)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

In the course of our continuing research for novel antimalarial agent from Indonesian plants, the methanol extract of the Erythrina variegata leaves showed significant antimalarial activity against Plasmodium falciparum strain K1 in vitro with IC50 6.8 μg/mL. The methanol extract was separated by using variety of chromatography techniques. The chemical structure of an antimalarial compound was determined on the basis of spectroscopic evidence and compared to previous data then this compound is identified as a pentacyclic triterpenoid oleane derivative, namely 3,22,23-trihydroxy-oleane-12-ene. The pentacyclic triterpenoid, 3,22,23-trihydroxy-oleane- 12-ene showed antimalarial activity against 3D7 and K1 strains with IC50 4.3 μg/mL and 24 μg/mL, respectively. These results strongly suggested that E. variegata is a promising sources of antimalarial agents.
Co-Authors Anas Subarnas Anas Urbanas Nasrudin Nasrudin Noor Rain Abdullah Supriyatna Sutardjo Tati Herlina Unang Supratman