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All Journal Jurnal Ilmu Ternak Veteriner
Mehrdad Shariati
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun
Veterinary

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Effects of Silybum marianum Aqueous Extract and L-carnitine on Stereological Changes in Diazinon-Treated Rat Liver Forough Masoumi; Mehrdad Shariati; Mokhtar Mokhtari
Jurnal Ilmu Ternak dan Veteriner Vol 25, No 2 (2020): JUNE 2020
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v25i2.2467

Abstract

As an organophosphorus, Diazinon (DZN) impairs liver tissue function by inhibiting acetylcholinesterase and causing oxidative stress. In this study, the effects of Silybum marianum aqueous extract (SMAE) and L-carnitine (LC) on the stereological and histopathological changes of the liver in DZN-treated male rats were investigated. The rats in this study were placed into 9 groups of 8 each containing control, placebo, and a combination of DZN, SMAE, and LC. The animals received SMAE and chemicals orally for 30 days. At last, the liver tissue of all animals was removed. Then, tissue sections from the liver were provided to study the stereological markers including liver volume and weight, hepatocytes’ volume, central venous volume, sinusoidal volume, connective tissue volume, inflammation rate, and a number of the hepatocytes’ nuclei. Also, the sample tissues were evaluated histopathologically. Treatment with DZN significantly reduced the liver volume and weight, hepatocyte volume, central venous volume, sinusoidal volume, and hepatocyte nucleus number compared to placebo and control but it significantly increased the inflammation and volume of liver’s connective tissue. However, co-administration of SMAE and LC with DZN improved liver volume and weight, hepatocyte volume, central venous volume, sinusoidal volume, connective tissue volume, and hepatocyte nucleus number alone compared to the DZN treatment. Liver inflammation was also significantly decreased compared to the DZN treatment but comparing to the placebo and control groups, it increased significantly. Simultaneous administration of SMAE and LC has protective effects on liver tissue and can reduce DZN-induced liver injury in rats.
Studying the Liver Function in Male Neonates of Rats Born to Sertraline-Treated Mothers Vida Safaei; Mehrdad Shariati
Jurnal Ilmu Ternak dan Veteriner Vol 26, No 3 (2021): September 2021
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v26i3.2945

Abstract

Sertraline is an antidepressant which has toxic effects on the liver. This study was conducted to evaluate the effect of Sertraline administration in pregnancy on liver function of male neonates of rats. Twenty-five pregnant female Wistar rats were divided into 4 groups of 5. The control group did not receive any drug treatments, but experimental (Exp) groups 1, 2 and 3 received 5, 10 and 20 mg/kg Sertraline as gavage throughout the pregnancy, respectively. Twenty-two days after birth, male rats were divided into 4 groups of 10 based on the previous division and after weighing, by taking blood directly from the heart, serum levels of Alanine transaminase (Alt), Aspartate transaminase (AST), Alkaline phosphatase (Alp), Albumin (Alb), Total protein (TP), and Bilirubin (Bili) were measured and the liver tissue was also analyzed histopathologically after weighing. In Exp groups, a significant decrease in body weight, TP and Alb serum levels were observed compared to the control group (p<0.05). In Exp group 3, a significant decrease in liver weight was observed compared to the control group (p˂0.05). In Exp groups 2 and 3, a significant increase in serum levels of Alp, Alt and Bili in was observed compared to the control group (p˂0.05). A significant increase in AST serum level was observed in Exp groups compared to the control group (p˂0.05). Liver tissue destruction was observed in all 3 Exp groups. The administration of Sertraline in pregnant female rats causes liver damage and increases liver enzymes and blood biochemical parameters in their male offspring.
Effect of N-acetylcystein on ERK Gene Expression in Ovarian Tissue of Acrylamide-Treated Adult Rats Marziyeh Naimi; Mehrdad Shariati; Sirous Naeimi; Mohammad Amin Edalatmanesh
Jurnal Ilmu Ternak dan Veteriner Vol 25, No 1 (2020): MARCH 2020
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v25i1.2161

Abstract

Acrylamide (AA) is a toxic and carcinogenic compound produced in cooking process. The purpose of this study is to evaluate the effect of N-acetylcysteine (NAC) on extracellular signal-regulated kinase (ERK) gene expression level and ovarian histopathological changes in AA-treated rats. Thirty-six female adult Wistar rats were randomly divided into 6 groups including control, positive control (+VE Con), negative control (-VE Con), experimental 1 (Exp1), experimental 2 (Exp2) and experimental 3 (Exp3). Twenty eight days after the treatment, ERK gene expression level was measured by real-time PCR method and ovarian histopathological changes were evaluated. The ERK gene expression level was significantly decreased in the +VE Con, Exp1 and Exp2 groups as compared to the control group (p˂0.05), but not in the -VE Con and Exp3 groups (p˃0.05). Histologically, the +VE Con group showed a significant decrease in the number of primary, secondary and Graafian follicles as well as corpus luteum as compared to the control group (p˂0.05), but not in the negative, Exp2 and Exp3 groups (p˃0.05). In the Exp1 group, the number of primary and secondary follicles as well as corpus luteum significantly decreased (p˂0.05), however, the numbers of Graafian follicle and the corpus luteum were significantly increased as compared to the +VE Con group (p˂0.05). The AA was supposed to increase the apoptosis and folliculogenesis degradation in the rat ovarian tissue by decreasing ERK gene expression. Administration of NAC ameliorated the deleterious effects of AA in a dose-dependent manner and improve folliculogenesis by reducing apoptosis level. Thus, the NAC supplement could be helpful in ameliorating animal fertility.
Co-Authors Forough Masoumi Marziyeh Naimi Mohammad Amin Edalatmanesh Mokhtar Mokhtari Sirous Naeimi Vida Safaei