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All Journal Jurnal Ilmu Ternak Veteriner
Mohammad Amin Edalatmanesh
Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Veterinary

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Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles Rahimeh Khezri Motlagh; Akbar Vahdati; Seyed Ebrahim Hosseini; Mohammad Amin Edalatmanesh
Jurnal Ilmu Ternak dan Veteriner Vol 27, No 1 (2022): March 2022
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v27i1.2971

Abstract

Nickel nanoparticles (NiNPs) have toxic effects on body cells due to the production of free radicals. The purpose of this research was to investigate the protective effects of Gallic acid (GA) and Curcumin (Cur) on hepatic transaminases, blood plasma parameters and pituitary-testicular hormones levels in NiNPs-treated rats. Seventy adult male Wistar rats were divided in 7 groups of 10 including control, Ni50 mg/kg, Ni50+GA150 mg/kg, Ni50+GA300 mg/kg, Ni50+Cur150 mg/kg, Ni50+Cur300 mg/kg and Ni50+GA300+CUR300 mg/kg. NiNPs, GA and Cur were administered orally by oral gavage for 28 days. At the last phase of the study, the samples of blood were taken directly from heart and serum levels of hepatic transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), blood plasma parameters (Glucose, total protein (TP), bilirubin (Bil), albumin (Alb), creatinine (Cr), Blood urea nitrogen (BUN), triglyceride, cholesterol, HDL, LDL and alkaline phosphatase (ALP)) and pituitary-testicular hormones (FSH, LH, testosterone and dihydrotestosterone) were assessed. NiNPs administration increased serum levels of glucose, ALT, ALP, AST, Bil, BUN, Cr, triglyceride, cholesterol and LDL compared to the control group (p0.05) and in contrast, it decreased serum levels of FSH, LH, testosterone, dihydrotestosterone, Alb, TP and HDL (p0.05). However, co-administration of GA and Cur at doses of 300 ml/kg in NiNPs -treated rats improved all blood plasma parameters compared to the control group (p0.05). The findings of this study suggest that co-administration of GA and Cur at a dose of 300 mg/kg can reduce and improve the damaging effects of NiNPs on blood plasma parameters, hepatic transaminases and pituitary-testicular hormones in adult rats.
Improving the Effects of Omega-3 Fatty Acid on the In Vitro Maturation of Oocytes Masume Ghorbani Vahed; Ramazan Khanbabaee; Mehrdad Shariati; Mohammad Amin Edalatmanesh
Jurnal Ilmu Ternak dan Veteriner Vol 25, No 4 (2020): December 2020
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v25i4.2555

Abstract

This research was conducted in order to determine the effects of omega-3 on oocyte in vitro maturation and the level of expression of tribbles (TRIB1, TRIB2 and TRIB3 genes) in cumulus cells. Eight-ten weeks old NMRI mice were super-ovulated using 7.5 IU pregnant mare’s serum gonadotropin (PMSG, Intraperitoneal) and they were killed after 44 hours and their ovaries were removed. The oocytes were used for in vitro maturation and the cumulus-oocyte complexes (COCs) were released. Cumulus cells and oocytes were assigned into control, ethanol-treated and groups exposed to 10 and 100 μg/ml of omega-3. The cells were prepared to assess the maturation stage in order to evaluate the gene expression level. The data were statistically analyzed. Exposing oocytes to low dose (10 μg/ml) and high dose (100 μg/ml) of omega-3 resulted in a reduced rate of GV-stage oocytes, decreased MI-oocytes and increased MII-oocytes. The enhanced maturity of COCs was also detected in response to a high dose of omega-3 (100 μg/ml). Exposure of cumulus cells to omega-3 (10 and 100 μg/ml) induced TRIB2 and inhibited TRIB3 gene expression level; however, TRIB1 gene expression level increased and decreased in response to low (10 μg/ml) and high (100 μg/ml) concentrations of omega-3, respectively. The addition of omega-3 to the environment of oocytes or cumulus cells affected the maturation of oocytes and cumulus cells, which was followed by the differential expression of TRIB genes, suggesting that there was a role of fatty acid metabolism in the differentiation and maturation of cumulus cells.
Effect of N-acetylcystein on ERK Gene Expression in Ovarian Tissue of Acrylamide-Treated Adult Rats Marziyeh Naimi; Mehrdad Shariati; Sirous Naeimi; Mohammad Amin Edalatmanesh
Jurnal Ilmu Ternak dan Veteriner Vol 25, No 1 (2020): MARCH 2020
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v25i1.2161

Abstract

Acrylamide (AA) is a toxic and carcinogenic compound produced in cooking process. The purpose of this study is to evaluate the effect of N-acetylcysteine (NAC) on extracellular signal-regulated kinase (ERK) gene expression level and ovarian histopathological changes in AA-treated rats. Thirty-six female adult Wistar rats were randomly divided into 6 groups including control, positive control (+VE Con), negative control (-VE Con), experimental 1 (Exp1), experimental 2 (Exp2) and experimental 3 (Exp3). Twenty eight days after the treatment, ERK gene expression level was measured by real-time PCR method and ovarian histopathological changes were evaluated. The ERK gene expression level was significantly decreased in the +VE Con, Exp1 and Exp2 groups as compared to the control group (p˂0.05), but not in the -VE Con and Exp3 groups (p˃0.05). Histologically, the +VE Con group showed a significant decrease in the number of primary, secondary and Graafian follicles as well as corpus luteum as compared to the control group (p˂0.05), but not in the negative, Exp2 and Exp3 groups (p˃0.05). In the Exp1 group, the number of primary and secondary follicles as well as corpus luteum significantly decreased (p˂0.05), however, the numbers of Graafian follicle and the corpus luteum were significantly increased as compared to the +VE Con group (p˂0.05). The AA was supposed to increase the apoptosis and folliculogenesis degradation in the rat ovarian tissue by decreasing ERK gene expression. Administration of NAC ameliorated the deleterious effects of AA in a dose-dependent manner and improve folliculogenesis by reducing apoptosis level. Thus, the NAC supplement could be helpful in ameliorating animal fertility.
Co-Authors Akbar Vahdati Marziyeh Naimi Masume Ghorbani Vahed Mehrdad Shariati Mehrdad Shariati Rahimeh Khezri Motlagh Ramazan Khanbabaee Seyed Ebrahim Hosseini Sirous Naeimi