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All Journal Jurnal Ilmu Ternak Veteriner The Indonesian Biomedical Journal
Akbar Vahdati
Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Biochemistry, Genetics & Molecular Biology Public Health Veterinary

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Protective Effects of Gallic Acid and Curcumin on Serum Levels of Hepatic Transaminases, Blood Plasma Parameters and Pituitary-testicular Hormones in Rats Treated Nickel Nanoparticles Rahimeh Khezri Motlagh; Akbar Vahdati; Seyed Ebrahim Hosseini; Mohammad Amin Edalatmanesh
Jurnal Ilmu Ternak dan Veteriner Vol 27, No 1 (2022): March 2022
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v27i1.2971

Abstract

Nickel nanoparticles (NiNPs) have toxic effects on body cells due to the production of free radicals. The purpose of this research was to investigate the protective effects of Gallic acid (GA) and Curcumin (Cur) on hepatic transaminases, blood plasma parameters and pituitary-testicular hormones levels in NiNPs-treated rats. Seventy adult male Wistar rats were divided in 7 groups of 10 including control, Ni50 mg/kg, Ni50+GA150 mg/kg, Ni50+GA300 mg/kg, Ni50+Cur150 mg/kg, Ni50+Cur300 mg/kg and Ni50+GA300+CUR300 mg/kg. NiNPs, GA and Cur were administered orally by oral gavage for 28 days. At the last phase of the study, the samples of blood were taken directly from heart and serum levels of hepatic transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), blood plasma parameters (Glucose, total protein (TP), bilirubin (Bil), albumin (Alb), creatinine (Cr), Blood urea nitrogen (BUN), triglyceride, cholesterol, HDL, LDL and alkaline phosphatase (ALP)) and pituitary-testicular hormones (FSH, LH, testosterone and dihydrotestosterone) were assessed. NiNPs administration increased serum levels of glucose, ALT, ALP, AST, Bil, BUN, Cr, triglyceride, cholesterol and LDL compared to the control group (p0.05) and in contrast, it decreased serum levels of FSH, LH, testosterone, dihydrotestosterone, Alb, TP and HDL (p0.05). However, co-administration of GA and Cur at doses of 300 ml/kg in NiNPs -treated rats improved all blood plasma parameters compared to the control group (p0.05). The findings of this study suggest that co-administration of GA and Cur at a dose of 300 mg/kg can reduce and improve the damaging effects of NiNPs on blood plasma parameters, hepatic transaminases and pituitary-testicular hormones in adult rats.
The Effect of Estradiol on Renal Function in Reversible and Irreversible Unilateral Ureteral Obstruction in Rats Zahra Lak; Akbar Vahdati; Mehdi Nematbakhsh
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.459

Abstract

BACKGROUND: The ureteral obstruction (UO) is the most common clinical disorders. This study was designed to investigate the renoprotective effect of estradiol in unilateral UO (UUO) and reversible UUO (RUUO).METHODS: Eighty-four ovareictomized Wistar rats were assigned into 14 groups. Group 1 was sham operated group. All the groups 2-14 were subject to UUO, however they received additional treatments. Group 2-4 received test substances (vehicle, 0.1 or 0.05 mg/kg of estradiol) and sacrificed after 3 days. Group 5-7 received test substances and after 3 days followed by RUUO (obstruction removal) and after one day post RUUO were sacrificed. Group 8-9 followed by RUUO after 3 days and simultaneously received estradiol and after one day post RUUO were sacrificed. Group 10-12 followed by RUUO after 3 days and simultaneously received test substances and after 3 days post RUUO were sacrificed. Group 13-14 received test substances followed by RUUO and received test substances again and after 3 days post RUUO were sacrificed.RESULTS: The estradiol reduced body weight significantly (p<0.05) in UUO, and the uterus weight (UW) increased significantly by estradiol (p<0.05). The increased serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney weight (KW) induced by UUO (p<0.05) were not attenuated by estradiol. Estradiol treatment did not alter the levels of BUN, Cr, KW, Cr clearance (CrCl), urine sodium excretion and urine flow when compared with control.CONCLUSION: Although the protective role of estradiol in cardiovascular system is well accepted, however our findings suggest that its protection during UUO or after RUUO in renal system cannot be certain.KEYWORDS: estradiol, ureteral obstruction, renal function, rat
Co-Authors Mehdi Nematbakhsh Mohammad Amin Edalatmanesh Rahimeh Khezri Motlagh Seyed Ebrahim Hosseini Zahra Lak