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Didik Tulus Subekti
Indonesian Research Center for Veterinary Sciences
Veterinary

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Antimicrobial, Antioxidant and Anti-inflammation Activities of Fraction and Single Peptides Derived from Mare Milk Protein Eni Kusumaningtyas; Didik Tulus Subekti; D FL Fitaningtyas
Jurnal Ilmu Ternak dan Veteriner Vol 24, No 3 (2019): SEPTEMBER 2019
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v24i3.1976

Abstract

Mare milk protein contains bioactive peptide which beneficial for human and animal health. Peptides in the fraction and single may show different activities.  The objectives of the study were to evaluate antimicrobial and anti-inflammation activities of the fraction and single peptide derived from mare milk protein. Antimicrobial assay was conducted by testing antibacterial and antifungal activities of fraction <3 kDa, peptide HPYFYAPELLYYANK, LVNELTEFAK and LANSLTEFAK against Escherichia coli and Candida albicans. Anti-inflammation effect was detected by interleukin 1-β (IL- 1β) and Tumor Necrosis Factor -α (TNF-α) production in mice after administration of Escherichia coli’s lipopolysaccharide (LPS) and combined with fraction or single peptide. The result showed that antibacterial and antifungal of fraction <3 kDa was higher than all of single peptide. This may because of synergistic interaction among peptide in the fraction which increase the activities. Fraction <3 kDa was also able to decrease production of IL-1β and TNF-α better than single peptide indicated its ability to decrease inflammation. Based on the results, antimicrobial and anti-inflammation activities fraction <3 kDa was better than single peptide. 
Co-Authors D FL Fitaningtyas Eni Kusumaningtyas