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All Journal Acta Interna : The Journal of Internal Medicine Cermin Dunia Kedokteran
Vivin Hudiyanti
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Health Professions Medicine & Pharmacology Public Health

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Effect of Curcuminoid versus Diclofenac Sodium on Monocytes Secretion of Tumor Necrosis Factor–α in Knee Osteoarthritis Hudiyanti, Vivin
Acta Interna The Journal of Internal Medicine Vol 2, No 1 (2012): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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Abstract

ABSTRACTBackground. Tumor Necrosis Factor-α (TNF-α), a pro-inflammatory cytokine produced by monocyte is increased in osteoarthritis synovial fluid. Curcuminoid from Curcuma domestica Val. suppresses the secretion of TNF-α.Objective. The purpose of this study was to investigate the suppression effect of curcuminoid from Curcuma domestica Val on synovial fluid monocyte’s TNF-α secretion compared to diclofenac sodium in knee osteoarthritisMethods. A prospective randomized open end blinded evaluation (PROBE) method was applied. Subjects were patients with knee osteoarthritis visiting Rheumatology Clinic Dr. Sardjito Hospital and Wirosaban Hospital Yogyakarta. Curcuminoid 30 mg three times daily or diclofenac sodium 25 mg three times daily were administered for 4 weeks. The level of TNF-α secreted by synovial fluid’s monocytes were measured by ELISA before and after treatment.Results. A total of 80 subjects were enrolled, 39 subjects on curcuminoid treatment groups and 41 subjects on diclofenac sodium group. Seven subjects were dropped out, 5 from the curcuminoid group and 2 from the diclofenac sodium group. There was a significant decrement of TNF-α level during 4 weeks treatment in both groups (p< 0.001 respectively). There was no significant difference on TNF-α levels between groups (p= 0,237), neither in 50% decrement of TNF-α levels (p= 518).Conclusion. The effect of curcuminoid in decreasing TNF- α level on patients with osteoarthritis is similar with sodium diclofenac. Keywords: osteoarthritis-monocyte-TNF-α-curcuminoid-diclofenac sodium
Gambaran Kasus Leptospirosis di RSUD Kota Surakarta, 2015-2018 Suprapto, Ivan Aristo; Mahendrakrisna, Daniel; Indianto, Wahyu; Hudiyanti, Vivin
Cermin Dunia Kedokteran Vol 47, No 2 (2020): Penyakit Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.808 KB) | DOI: 10.55175/cdk.v47i2.352

Abstract

Latar Belakang. Indonesia memiliki angka kejadian leptospirosis masih cukup tinggi, terutama di beberapa kota besar di Indonesia. Metode. Penelitian deskriptif analitik di Rumah Sakit Umum Daerah Kota Surakarta. Populasi penelitian ini adalah penderita leptospirosis di RSUD Kota Surakarta pada periode Januari 2015 hingga April 2018. Data demografik merupakan data sekunder dari rekam medis berupa usia, jenis kelamin, alamat, daerah tinggal, riwayat paparan atau pekerjaan, bulan dan tahun rawat, kondisi saat pulang, diagnosis, gejala klinis pendukung kasus suspek dan kasus probable, dan hasil serokonversi. Analisis uji univariat dengan data nominal dipresentasikan menggunakan frekuensi dan persentase. Hasil. Total ada 100 penderita pada penelitian ini terutama pada usia produktif yaitu kelompok usia 46-60 tahun (42.6%) dan laki-laki (81%). Rerata usia 49.98 tahun. Kota Solo merupakan daerah asal pasien terbanyak sebesar 51%, dan 39% bertempat tinggal di kecamatan Banjarsari di kota Solo. Kasus leptospirosis lebih sering pada musim penghujan puncaknya bulan Maret (24%). Insidensi leptospirosis terbanyak di tahun 2017 yaitu 39 kasus (39%). Simpulan. Insiden leptospirosis di kota Surakarta dan sekitarnya masih tergolong tinggi.Background. Indonesia has a high reported leptospirosis incidence, especially in several major cities in Indonesia. Method. This study is a descriptive analytic study conducted at the Surakarta City General Hospital. The population was leptospirosis patients in Surakarta City Hospital in the period January 2015 to April 2018. Secondary demographic data was taken from medical records; consist of age, sex, address, area of residence, exposure history or occupation, month and year of admission, clinical symptoms, diagnosis, conditions at discharge, and seroconversion results. Statistical univariate analysis with nominal data presented using frequency and percentage. Results. From 100 leptospirosis patients in this study, the average age of subjects was 49.98 years; mostly male (81%) in productive age group 46-60 years (42.6%). Most patients came from the city of Solo (51%), and 39% live in the sub-district Banjarsari. Leptospirosis cases are more common in the peak rainy season in March (24%). The highest incidence with 39 cases (39%) was in 2017. Conclusion. The incidence of leptospirosis in Surakarta and surrounding cities is still relatively high.
Effect of Curcuminoid versus Diclofenac Sodium on Monocytes Secretion of Tumor Necrosis Factor–α in Knee Osteoarthritis Vivin Hudiyanti
Acta Interna The Journal of Internal Medicine Vol 2, No 1 (2012): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1336.388 KB) | DOI: 10.22146/acta interna.3873

Abstract

ABSTRACTBackground. Tumor Necrosis Factor-α (TNF-α), a pro-inflammatory cytokine produced by monocyte is increased in osteoarthritis synovial fluid. Curcuminoid from Curcuma domestica Val. suppresses the secretion of TNF-α.Objective. The purpose of this study was to investigate the suppression effect of curcuminoid from Curcuma domestica Val on synovial fluid monocyte’s TNF-α secretion compared to diclofenac sodium in knee osteoarthritisMethods. A prospective randomized open end blinded evaluation (PROBE) method was applied. Subjects were patients with knee osteoarthritis visiting Rheumatology Clinic Dr. Sardjito Hospital and Wirosaban Hospital Yogyakarta. Curcuminoid 30 mg three times daily or diclofenac sodium 25 mg three times daily were administered for 4 weeks. The level of TNF-α secreted by synovial fluid’s monocytes were measured by ELISA before and after treatment.Results. A total of 80 subjects were enrolled, 39 subjects on curcuminoid treatment groups and 41 subjects on diclofenac sodium group. Seven subjects were dropped out, 5 from the curcuminoid group and 2 from the diclofenac sodium group. There was a significant decrement of TNF-α level during 4 weeks treatment in both groups (p< 0.001 respectively). There was no significant difference on TNF-α levels between groups (p= 0,237), neither in 50% decrement of TNF-α levels (p= 518).Conclusion. The effect of curcuminoid in decreasing TNF- α level on patients with osteoarthritis is similar with sodium diclofenac. Keywords: osteoarthritis-monocyte-TNF-α-curcuminoid-diclofenac sodium
Co-Authors Mahendrakrisna, Daniel Suprapto, Ivan Aristo Wahyu Indianto, Wahyu