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Spontaneous Intestinal Perforation in Neonate Ade Nofendra; Eny Yantri; Anggia Perdana Harmen
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.1022

Spontaneous Intestinal Perforation (SIP) terjadi pada 8,4 persen bayi dengan berat badan lahir sangat rendah. SIP ditandai dengan onset mendadak dan tidak ditemukannya tanda infeksi. Presentasi klinis SIP pada bayi bervariasi, dan etiologinya belum diketahui secara pasti. Konsekuensi klinis SIP dapat menimbulkan komplikasi yang cukup parah sehingga dokter harus menyadari kemungkinan penyebab dan gejala. Terapi utama SIP yaitu: drainase peritoneum dan laparotomi dengan reseksi. Dilaporkan kasus SIP pada by perempuan usia 2 hari, yang didiagnosis berdasarkan gejala klinis dan rontgen abdomen. Pasien dilakukan pemasangan drainase di abdomen dan mengamai perbaikan klinis.

Staphylococcal Scalded Skin Syndrome in Healthy Infant Anggia Perdana Harmen; Eny Yantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.398

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

Staphylococcal Scalded Skin Syndrome in Healthy Infant Anggia Perdana Harmen
Majalah Kedokteran Andalas Vol 45, No 3 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i1.p59-70.2021

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

Vascular Architecture Alterations Independent of Lipid Profiles: The Paradoxical Dissociation between Dyslipidemia and Carotid Intima-Media Thickness in Obese Adolescents Yenny Astari; Didik Hariyanto; Eka Agustia Rini; Eva Chundrayetti; Nice Rachmawati Masnadi; Anggia Perdana Harmen; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1564

Background: Adolescent obesity is a global epidemic that initiates subclinical atherosclerosis. While lipid profiles are traditional markers, their correlation with structural vascular changes in the pediatric population remains a subject of intense academic debate. This study evaluates the relationship between traditional lipid parameters and carotid intima-media thickness (CIMT) in obese high school students. Methods: An observational cross-sectional study was conducted between January 2025 and January 2026 involving 45 obese adolescents aged 15 to 18 years in Padang, Indonesia. Nutritional status was determined using the CDC 2000 growth charts, specifically targeting those with a body mass index at or above the 95th percentile. CIMT was measured via high-resolution B-mode ultrasonography. Lipid profiles, including total cholesterol, triglycerides, HDL, and LDL, were analyzed through laboratory testing. Statistical analysis utilized Fisher’s exact test through SPSS version 22. Results: The subjects, of whom 68.9 percent were female, had a median BMI of 29.34 ± 2.03 kg/m². Remarkably, 68.9 percent exhibited CIMT thickening above the 75th percentile. Bivariate analysis revealed no significant association between CIMT and total cholesterol (p=0.402), triglycerides (p=0.696), HDL (p=0.563), or LDL (p=1.000). Conclusion: Vascular remodeling in obese adolescents occurs independently of circulating lipid levels, suggesting that chronic inflammation may drive early atherosclerosis before clinical dislipidemia manifests.

Vascular Architecture Alterations Independent of Lipid Profiles: The Paradoxical Dissociation between Dyslipidemia and Carotid Intima-Media Thickness in Obese Adolescents Yenny Astari; Didik Hariyanto; Eka Agustia Rini; Eva Chundrayetti; Nice Rachmawati Masnadi; Anggia Perdana Harmen; Rinang Mariko
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1564

Background: Adolescent obesity is a global epidemic that initiates subclinical atherosclerosis. While lipid profiles are traditional markers, their correlation with structural vascular changes in the pediatric population remains a subject of intense academic debate. This study evaluates the relationship between traditional lipid parameters and carotid intima-media thickness (CIMT) in obese high school students. Methods: An observational cross-sectional study was conducted between January 2025 and January 2026 involving 45 obese adolescents aged 15 to 18 years in Padang, Indonesia. Nutritional status was determined using the CDC 2000 growth charts, specifically targeting those with a body mass index at or above the 95th percentile. CIMT was measured via high-resolution B-mode ultrasonography. Lipid profiles, including total cholesterol, triglycerides, HDL, and LDL, were analyzed through laboratory testing. Statistical analysis utilized Fisher’s exact test through SPSS version 22. Results: The subjects, of whom 68.9 percent were female, had a median BMI of 29.34 ± 2.03 kg/m². Remarkably, 68.9 percent exhibited CIMT thickening above the 75th percentile. Bivariate analysis revealed no significant association between CIMT and total cholesterol (p=0.402), triglycerides (p=0.696), HDL (p=0.563), or LDL (p=1.000). Conclusion: Vascular remodeling in obese adolescents occurs independently of circulating lipid levels, suggesting that chronic inflammation may drive early atherosclerosis before clinical dislipidemia manifests.

Hubungan Derajat Aktivitas LES dengan Kejadian Anemia di RS Dr. M. Djamil Alifah Amirah; Afdal Afdal; Dwitya Elvira; Efrida Efrida; Anggia Perdana Harmen; Zurayya Fadila
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1453

Latar Belakang: Lupus eritematosus sistemik (LES) merupakan penyakit autoimun yang berhubungan dengan berbagai sistem tubuh dan berhubungan secara signifikan dengan morbiditas dan mortalitas. Anemia pada penderita LES banyak terjadi akibat penyakit kronis. Anemia dapat menggambarkan tingkat keparahan penyakit yang mendasarinya sehingga evaluasi terhadap derajat aktivitas penyakit, salah satu caranya dengan menggunakan MEX-SLEDAI dan status anemia pasien LES diperlukan untuk menentukan rencana pengawasan dan tatalaksana dari pasien tersebut. Objektif: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara derajat aktivitas penyakit dengan kejadian anemia pada pasien LES di RS Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan cross-sectional menggunakan data sekunder dari rekam medik pasien LES di RS Dr. M. Djamil Padang dan derajat aktivitas penyakit didapatkan berdasarkan MEX-SLEDAI. Teknik pengambilan sampel dengan consecutive sampling dengan total 69 sampel. Analisis data yang dilakukan menggunakan uji Fisher’s Exact dalam SPSS versi 29. Hasil: Hasil penelitian didapatkan mayoritas pasien LES berjenis kelamin perempuan (98,6%) dengan kelompok usia 18-25 tahun (40,6%), dan mayoritas dengan derajat aktivitas penyakit berat (53,6%). Penelitian ini didapatkan angka kejadian anemia pada derajat aktivitas penyakit ringan-sedang (87,5%) dan derajat aktivitas penyakit berat (89,2%) dengan hasil uji statistik didapatkan nilai p >0,05. Kesimpulan: Penelitian ini menunjukkan bahwa tidak terdapat hubungan yang signifikan antara derajat aktivitas penyakit dengan kejadian anemia pada pasien LES di RS Dr. M. Djamil Padang.

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