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Spontaneous Intestinal Perforation in Neonate Ade Nofendra; Eny Yantri; Anggia Perdana Harmen
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.1022

Spontaneous Intestinal Perforation (SIP) terjadi pada 8,4 persen bayi dengan berat badan lahir sangat rendah. SIP ditandai dengan onset mendadak dan tidak ditemukannya tanda infeksi. Presentasi klinis SIP pada bayi bervariasi, dan etiologinya belum diketahui secara pasti. Konsekuensi klinis SIP dapat menimbulkan komplikasi yang cukup parah sehingga dokter harus menyadari kemungkinan penyebab dan gejala. Terapi utama SIP yaitu: drainase peritoneum dan laparotomi dengan reseksi. Dilaporkan kasus SIP pada by perempuan usia 2 hari, yang didiagnosis berdasarkan gejala klinis dan rontgen abdomen. Pasien dilakukan pemasangan drainase di abdomen dan mengamai perbaikan klinis.

Peran Sistem Skoring Hematologi dalam Diagnosis Awal Sepsis Neonatorum Awitan Dini Ranti Adriani; Eny Yantri; Rinang Mariko
Sari Pediatri Vol 20, No 1 (2018)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Sepsis neonatorum awitan dini (SNAD) merupakan penyebab utama kesakitan dan kematian pada neonatus. Adanya gejala klinis yang tidak spesifik dan keterbatasan sarana pemeriksaan penunjang masih merupakan masalah dalam diagnosis sepsis. Sistem skoring hematologi (SSH) dapat digunakan sebagai metode deteksi awal SNAD. Tujuan. Mengetahui apakah sistem skoring hematologi (SSH) dapat digunakan dalam diagnosis awal SNAD.Metode. Penelitian ini merupakan penelitian cross sectional dan uji diagnostik pada bayi dengan risiko dan diduga sepsis neonatorum awitan dini yang dirawat di NICU/Perinatologi RSUP Dr. M Djamil Padang dari bulan Oktober 2016 hingga Juni 2017. Diagnosis sepsis ditegakkan berdasarkan pemeriksaan klinis dan biakan darah. Sistem skoring hematologi terdiri delapan parameter hematologis.Hasil. Subjek penelitian 78 pasien, terdiri dari tidak sepsis 30 orang (38%) sepsis klinis 28 orang (36%) dan terbukti sepsis 20 orang (26%). Nilai SSH tidak sepsis lebih rendah dari kelompok sepsis klinis dan terbukti sepsis. Tidak terdapat perbedaan yang bermakna nilai SSH kelompok terbukti sepsis dan sepsis klinis. Nilai SSH â‰¥2 memiliki nilai sensitifitas 100%, spesifitas 25,8 % dalam mendiagnosis sepsis (bakteremia ) pada bayi dengan dugaan SNAD. Kesimpulan. Sistem skoring hematologi ini dapat digunakan sebagai metode deteksi awal sepsis neonatorum awitan dini, terutama di rumah sakit dengan sarana pemeriksaan penunjang terbatas.

Staphylococcal Scalded Skin Syndrome in Healthy Infant Anggia Perdana Harmen; Eny Yantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.398

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

Kadar insulin-like growth factor-1, ghrelin ASI, dan peningkatan berat badan bayi pada ibu menyusui obesitas dan normal Desriati Sinaga; Eny Yantri; Yusrawati Yusrawati
Jurnal Gizi Klinik Indonesia Vol 15, No 1 (2018): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.34939

Background: Obesity is one of the factors that trigger the incidence of non-communicable diseases and increase morbidity rates in mothers and infants. Ghrelin hormone in breast milk serves to stimulate appetite in infants as well as release factors for growth hormone (GH). Insulin-like growth factor 1 (IGF-1) hormone in breast milk plays a role in increasing the length of bone and muscle mass of infants and mediators of GH work. Obesity can affect baby's weight gain, ghrelin and IGF-1 hormone levels in breast milk.Objective: Analyzes the association of IGF-1 and ghrelin levels of breast milk with baby's weight gain between obese and normal mothers.Method: Observational study with cross sectional design on 40 breastfeeding mothers and their infants in the work area of Andalas Health Center, Ikur Koto Health Center and Puskesmas Lubuk Buaya Padang City with consecutive sampling technique from August to November 2017. The examination of IGF-1 and ghrelin levels was conducted at the University's Biomedical Laboratory Andalas with ELISA method. Weight gain is obtained from first month infant weight loss with infant birth weight. Data analysis used independent t-test and Pearson test.Results: There was a difference in IGF-1 levels in breast milk (p=0.00) between obese and normal mothers. There was no difference in ghrelin levels of breast milk (p=0.90) between obese and normal mothers. There was a difference in weight gain between obese and normal mothers (p=0.02). There was no significant association between IGF-1 and ghrelin levels of breast milk with an increase baby weight gain between obese and normal mothers.Conclusion: There was no significant association between IGF-1 and ghrelin levels of breast milk with an increase baby weight gain between obese and normal mothers.

Staphylococcal Scalded Skin Syndrome in Healthy Infant Anggia Perdana Harmen; Eny Yantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.398

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

PENGARUH BILIRUBIN TERHADAP T HELPER PADA NEONATUS DAPAT MENINGKATKAN TERJADINYA RESIKO ALERGI Andriani Liberti; Rusdi -; Eny Yantri
HUMAN CARE JOURNAL Vol 6, No 1 (2021): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v6i1.1081

ABTRACTThe prevalence of allergic diseases globally increased in the last decade influenced by various factors.1 One of the factors associated is hyperbilirubinemia at neonatal period, which can later develop into an allergic disease.2 Bilirubin is a powerful antioxidant, which can be distributed into tissues. Bilirubin also has an immunomudulatory effect, it inhibit the response of Th1 cells and lowering interleukin-2 (IL-2) production. This decrease in IL-2 levels disrupted the balance of Th1-Th2 to Th2.3 At the time of the increase in bilirubin levels, there is an increase in the complement of prooxidant effects due to the breakdown of heme that can trigger the occurrence of inflammation of the respiratory tract in the future.4 In addition, in a study it was found that the effects of bilirubin that are not contracted can inhibit the growth of anaerobic bacteria in the gastrointestinal tract, thereby altering the composition of the intestinal microbiota and inhibiting the response of Th1 so that it can develop into an allergic disease.5 This rise a hypothesis that there is an influence of bilirubin on balance T helper that can increase the risk of occurrence of allergies in the future. Keywords: Bilirubin, neonates, T helper, immune system, allergy ABSTRAKPrevalensi penyakit alergi secara global meningkat pada dekade akhir ini yang dipengaruhi oleh berbagai faktor.1 Salah satu faktor yang dihubungkan yaitu hiperbilirubinemia pada saat neonatus, yang kemudian hari dapat berkembang menjadi penyakit alergi. 2 Bilirubin merupakan antioksidan kuat, yang dapat didistribusikan kedalam jaringan. Bilirubin juga memiliki efek immunomudulator, yaitu dengan menghambat respon sel Th1 dan menurunkan produksi interleukin-2 (IL-2). Penurunan kadar IL-2 ini mengganggu keseimbangan Th1-Th2 menuju ke Th2.3 Pada saat terjadinya peningkatan kadar bilirubin, terjadi peningkatan komplemen efek prooksidan akibat pemecahan heme yang dapat memicu terjadinya inflamasi pada saluran pernafasan dikemudian hari.4 Selain itu, pada sebuah penelitian didapatkan bahwa efek bilirubin yang tidak terkonyugasi dapat menghambat pertumbuhan bakteri anaerob pada saluran cerna, sehingga mengubah komposisi mikrobiota usus dan menghambat respon Th1 sehingga dapat berkembang menjadi penyakit alergi .5 Hal ini memunculkan hipotesis bahwa terdapat pengaruh bilirubin terhadap keseimbangan T helper yang dapat meningkatkan terjadinya resiko terjadinya alergi dikemudian hari. Kata kunci: Bilirubin, neonatus, T helper, sistem imun, alergi

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