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All Journal Jurnal Kesehatan Andalas Indonesian Journal of Cardiology
Pradita Diah Permatasari
RSUP dr. M. Djamil Padang
Health Professions Medicine & Pharmacology

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Infektif Endokarditis Pada Penyakit Jantung Tiroid Pradita Diah Permatasari
Jurnal Kesehatan Andalas Vol 9, No 1 (2020): Online March 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i1.1265

Abstract

Infective endocarditis is an endocardial surface infection of the heart including heart valves that can be fatal. Occurs because there is damage to the surface of the endocardium and the entry of bacteria into the circulation. The presence of cardiac lesions such as mitral regurgitation can be a predisposing factor for infective endocarditis. Patients were diagnosed with infective endocarditis based on a scoring system consisting of clinical symptoms, imaging, and blood culture findings, namely: modified Duke criteria. Treatment of infective endocarditis consists of giving antibiotics and evacuating vegetation by surgery. Surgical action is indicated if there is symptoms of heart failure, uncontrolled infections and vegetation size are too large, causing the risk of embolism.
Effect of Remote Ischemic Postconditioning on miRNA-145 and Troponin I levels in STEMI patients undergoing primary percutaneous coronary intervention Pradita Diah Permatasari; Muhammad Fadil; Masrul Syafri
Jurnal Kardiologi Indonesia Vol 41 No 1 (2020): Indonesian Journal of Cardiology: Januari - Maret 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.989

Abstract

Background: Primary Percutaneous Coronary Intervention Procedure (PPCI) results in reperfusion injury which will result in more extensive infarction. Remote Ischemic Postconditioning (RIPC) is a protective strategy to reduce the increase in the area of ​​infarction. miRNA-145 also plays a role in the protective effect of IPC and RIPC. Research Methods: This study uses a pre and post test approach only with control group design with experimental research designs. Data is taken at the Integrated Heart Services Installation RSUP Dr. M. Djamil Padang from July to November 2019, 40 patients with ST-segment elevation myocardial infarction (STEMI) performed RIPC. Bivariate analysis was performed to determine differences in levels of miRNA-145 and troponin I in STEMI patients underwent PPCI with and without RIPC using the Wilcoxon test and the Mann Whitney test. Results:A total of 40 patients who underwent the PPCI procedure were divided into two groups PPCI + RIPC (n = 20) and PPCI without RIPC (n = 20). There were no significant differences in the basic characteristics between the two groups. There were no significant difference in escalation of median expression of miRNA-145 in PPCI+ RIPC [pre test 36.33 (27.44-52.39), post test 34.83 (27.65-65.26), p = 0.765] compared to PPCI without RIPC [pre test 31.66 (26.31-43.28), post test 33.43 (26.83-64.97), p = 0.765]. There were an increase in median troponin I levels in both groups, PPCI+ RIPC [pretest 4,104.70 (67.30-40,000.00), post test 30,448.50 (120.00-16.3192.20), p = 0.001] and PPCI without RIPC [pretest 826.50 (17.00-48.259.00), post test 42.784.50 (2,119.00-162.897.00), p = <0.001]. Conclusion:There were no significant difference in median expression of miRNA-145 in STEMI patients before and after (48 hours) underwent PPCI+RIPC and PPCI without RIPC. There were a significant difference in median levels of troponin I in STEMI patients before and after (48 hours) underwent PPCI+RIPC and PPCI without RIPC. Keywords: Remote Ischemic Postconditioning, miRNA-145, troponin I
Co-Authors Masrul Syafri Muhammad Fadil