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All Journal Indonesian Journal of Cardiology Journal of Midwifery Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Masrul Syafri
Cardiology And Vascular Medicine, Medical Faculty Of Andalas University/ RSUP Dr. M. Djamil Padang
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Uji Diagnostik Squatting Stress Echocardiography dengan Angiografi Koroner dalam Mendiagnosis Penyakit Jantung Koroner Andy Rahman; Mefri Yanni; Masrul Syafri
Jurnal Kardiologi Indonesia Vol. 37, No. 4 Oktober - Desember 2016
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v37i4.583

Abstract

Background: In patients with significant coronary heart disease (CHD), increased preload and afterload during a squat can cause wall motion abnormalities (WMA) which can be detected on echocardiography. This study was conducted to determine the diagnostic value of stress echocardiography squatting as a non-invasive examination of a relatively simple, inexpensive, and safe in the detection of coronary artery stenosis in stable CHD and unstable angina patients.Methods: This study was a cross-sectional design. The subjects were all patients with stable CHD and unstable angina whom were treated in Instalasi Pusat Jantung Rumah Sakit Dr. M. Djamil Padang from May to July 2016. Subjects underwent squatting stress echocardiography procedures followed by coronary angiography. Diagnostic test was used to determine the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of squatting stress echocardiography.Results: The sensitivity, specificity, and accuracy of squatting echocardiography for diagnosis of CAD were 90.3%, 88.9% and 89.7%, respectively.Conclusion: Squatting stress echocardiography can be proposed as a non-invasive examination which is relatively simple, inexpensive and safe to detect coronary artery stenosis on patients with stable CHD and unstable CHD.
Effect of Remote Ischemic Postconditioning on miRNA-145 and Troponin I levels in STEMI patients undergoing primary percutaneous coronary intervention Pradita Diah Permatasari; Muhammad Fadil; Masrul Syafri
Jurnal Kardiologi Indonesia Vol 41 No 1 (2020): Indonesian Journal of Cardiology: Januari - Maret 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.989

Abstract

Background: Primary Percutaneous Coronary Intervention Procedure (PPCI) results in reperfusion injury which will result in more extensive infarction. Remote Ischemic Postconditioning (RIPC) is a protective strategy to reduce the increase in the area of ​​infarction. miRNA-145 also plays a role in the protective effect of IPC and RIPC. Research Methods: This study uses a pre and post test approach only with control group design with experimental research designs. Data is taken at the Integrated Heart Services Installation RSUP Dr. M. Djamil Padang from July to November 2019, 40 patients with ST-segment elevation myocardial infarction (STEMI) performed RIPC. Bivariate analysis was performed to determine differences in levels of miRNA-145 and troponin I in STEMI patients underwent PPCI with and without RIPC using the Wilcoxon test and the Mann Whitney test. Results:A total of 40 patients who underwent the PPCI procedure were divided into two groups PPCI + RIPC (n = 20) and PPCI without RIPC (n = 20). There were no significant differences in the basic characteristics between the two groups. There were no significant difference in escalation of median expression of miRNA-145 in PPCI+ RIPC [pre test 36.33 (27.44-52.39), post test 34.83 (27.65-65.26), p = 0.765] compared to PPCI without RIPC [pre test 31.66 (26.31-43.28), post test 33.43 (26.83-64.97), p = 0.765]. There were an increase in median troponin I levels in both groups, PPCI+ RIPC [pretest 4,104.70 (67.30-40,000.00), post test 30,448.50 (120.00-16.3192.20), p = 0.001] and PPCI without RIPC [pretest 826.50 (17.00-48.259.00), post test 42.784.50 (2,119.00-162.897.00), p = <0.001]. Conclusion:There were no significant difference in median expression of miRNA-145 in STEMI patients before and after (48 hours) underwent PPCI+RIPC and PPCI without RIPC. There were a significant difference in median levels of troponin I in STEMI patients before and after (48 hours) underwent PPCI+RIPC and PPCI without RIPC. Keywords: Remote Ischemic Postconditioning, miRNA-145, troponin I
Profil Pasien Deep Vein Thrombosis di RSUP Dr. M. Djamil Padang Tahun 2018 Muhammad Farhan; Masrul Syafri; Tofrizal Tofrizal
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1259.561 KB) | DOI: 10.25077/jikesi.v2i2.531

Abstract

Latar Belakang. Deep Vein Thrombosis (DVT) merupakan sebuah kondisi oklusi yang disebabkan oleh terbentuknya trombus patologis pada sirkulasi vena dalam tubuh. DVT merupakan sebuah penyakit yang dapat dicegah namun masih memiliki tingkat morbiditas dan mortalitas yang tinggi. Pemeriksaan menggunakan Ultrasonografi (USG) Doppler merupakan metode yang direkomendasikan untuk menegakkan diagnosis DVT. Objektif. Tujuan penelitian ini adalah untuk mengetahui profil dari pasien DVT di RSUP Dr. M. Djamil Padang pada tahun 2018. Metode. Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional melalui pengumpulan data dari hasil pemeriksaan USG Doppler dan rekam medis. Background. Deep Vein Thrombosis (DVT) is an occlusion caused by patological thrombus that formed at deep vein circulation of the body. DVT is a preventable disease but the morbidity and mortality rate of DVT are still high. The recommended method for diagnosing DVT is by examination with Doppler Ultrasonography (USG) for identificating thrombus at deep vein circulation. Objective. The objective from this study is to identifying clinical profile of DVT patient at Dr. M. Djamil General Hospital Padang in 2018. Method. This is a descriptive observational research with cross sectional method by collecting data from Doppler USG examination report and patient medical record. Results. From this research we found 66 DVT patient, most patients were in the age group of 56-65 years old (23 patients), most thrombus located at lower extremities (49 patients), especially at femoral vein (29 patients). Mostly patients shown with swelling at thrombus location (59 patients), and immobilization was the most risk factor found in the patients (58 patients.) Conclusion. From this research we conclude that mostly DVT patients at M. Djamil General Hospital Padang are elderly and mainly women, mostly DVT located at left leg especially in femoral and poplitea vein and shown with swelling at leg, and mostly DVT patients were having immobilization and malignancy as risk factor. Keywords : Deep vein thrombosis, Doppler USG, clinical profile Hasil. Pada penelitian ini didapatkan 66 pasien DVT di RSUP Dr. M. Djamil Padang pada tahun 2018. Kelompok usia tertinggi ditemukan pada rentang usia 56-65 tahun sebanyak 23 pasien. Lokasi trombus paling sering ditemukan pada tungkai sebanyak 49 pasien, terutama pada vena femoralis sebanyak 29 pasien. Manifestasi klinis yang paling sering ditemukan berupa pembengkakan sebanyak 59 pasien, dan faktor risiko yang paling sering ditemukan imobilisasi sebanyak 58 pasien. Kesimpulan. Kebanyakan pasien DVT di RSUP Dr. M. Djamil Padang berusia lanjut serta memiliki DVT pada tungkai terutama pada vena femoralis sebelah kiri dengan manifestasi pembengkakan, dan memiliki faktor risiko imobilisasi. Perlunya penerapan profilaksis DVT pada pasien yang memiliki resiko tinggi untuk menekan angka kejadian DVT. Kata kunci: Deep vein thrombosis, USG Doppler, profil klinis
Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia Elly Usman; Gestina Aliska; Masrul Syafri
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.1-7.2022

Abstract

Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.
Co-Authors Andy Rahman Elly Usman Gestina Aliska Mefri Yanni Muhammad Fadil Muhammad Farhan Pradita Diah Permatasari Tofrizal Tofrizal