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Dyke Gita Wirasisya
University of Mataram
Environmental Science

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The Antibiofilm Activity of Jatropha curcas L.Latex on Staphylococcus aureus ATCC 25923 Rosmalinda Utami; Siti Rahmatul Aini; Dyke Gita Wirasisya
Natural B, Journal of Health and Environmental Sciences Vol 5, No 1 (2019)
Publisher : Natural B, Journal of Health and Environmental Sciences

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Abstract

Nosocomial infections worldwide shows high rates. One of the causes of nosocomial infections is Staphylococcus aureus. S. aureus as an infectious pathogen is known to form biofilms that often cause failure of antibiotic therapy. Jatropha is one of the plants used by the community in treating various diseases, including infections. The purpose of this study was to determine the jatropha latex antibiofilm activity on S. aureus by microdilution method with crystal violet staining. The results showed that jatropha latex extract had antibiofilm activity, with biofilm inhibition percentages of 150% at concentrations of 0.625 mg/mL, while percent degradation was 189% at concentrations of 5 mg/mL. Jatropha latex extract had biofilm inhibition activity at extract concentrations of 0.625 mg/mL and biofilm degradation at extract concentration of 5 mg/mL. The result of this study can be used as topical drugs for infectious wounds.
Antimicrobial Potential of Methanol Extract from Kastuba Leaf (Euphorbia pulcherrima Willd.) Atwazah Taisir Ibrahim; Kurniasih Suketi; Dyke Gita Wirasisya
Natural B, Journal of Health and Environmental Sciences Vol 5, No 1 (2019)
Publisher : Natural B, Journal of Health and Environmental Sciences

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Abstract

Some bacteria have been resistant to one or more types of antibiotics, so an effort to find new antimicrobial sources based on medicinal plants is needed. Research that has been done shows that there are 22 types of plants used as wound treatment used by local people of Timbanuh, East Lombok, one of them is kastuba (Euphorbia pulcherrima Willd.). This study was conducted to test the antimicrobial potential of kastuba leaf extract which has been used ethnomedicinely as a wound teratment in Timbanuh. The antimicrobial activity of kastuba extract was tested against Staphylococcus aureus bacteria. This test used 4 samples. Sample 1 (leaf part 1-5, wind dry method), samples 2 (leaf part 6-10, wind dry method), samples 3 (leaf part 11-15, wind dry method), and sample 4 (leaf part 11-15, oven dry method). The measurement of the antimicrobial potential was carried out by the well diffusion method. The results showed that kastuba leaf extract (samples 1 to 4) at concentration 10 mg / 100µL had a inhibition zone of 9,208; 10,041; 10,583; 11,541 mm and 11,85; 12.08; 14.25; 15.92 mm at concentration 20 mg / 100µL. Sample 4 showed larger inhibition zone affected by different drying method used. The conclusion of this study is kastuba leaf extract has the potential as an antimicrobial.
Co-Authors Atwazah Taisir Ibrahim Kurniasih Suketi Rosmalinda Utami Siti Rahmatul Aini