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All Journal The Journal of Pure and Applied Chemistry Research
Yeny Diah Rahmawati
Chemistry Department, Faculty of Mathematics and Natural Sciences, Brawijaya University
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats Yeny Diah Rahmawati; Aulanni’am Aulanni’am; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 8, No 1 (2019): Edition January-April 2019
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2019.008.01.430

Abstract

Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extract on hairless rats skin tissue exposed by UVB based on expression of TGF-β1, MMP-1 and MDA dermis. A total of 30 male-hairless rats (Rattus novergicus) divided into 6 experimental groups, exposed by UVB with total dose 840 mJ/cm2 for four weeks. Topical gel therapy administered twice a day, 20 minutes before and 4 hours after irradiation. Oral therapy administered once a day before irradiation. Expression of TGF-β1, MMP-1 and MDA dermis observed by immunohistochemistry. The result showed that oral and topical therapy of C. asiatica extract was capable of inhibiting the increase of MMP-1 and MDA expression and the decrease of TGF- β1 significantly (p<0.05) in the dermal fibroblast of Wistar rat that exposed UVB light.
Co-Authors Aulanni’am Aulanni’am Sasangka Prasetyawan