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All Journal The Journal of Pure and Applied Chemistry Research
Sasangka Prasetyawan
Chemistry Department, Faculty of Mathematics and Natural Sciences, Brawijaya University
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats Yeny Diah Rahmawati; Aulanni’am Aulanni’am; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 8, No 1 (2019): Edition January-April 2019
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2019.008.01.430

Abstract

Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extract on hairless rats skin tissue exposed by UVB based on expression of TGF-β1, MMP-1 and MDA dermis. A total of 30 male-hairless rats (Rattus novergicus) divided into 6 experimental groups, exposed by UVB with total dose 840 mJ/cm2 for four weeks. Topical gel therapy administered twice a day, 20 minutes before and 4 hours after irradiation. Oral therapy administered once a day before irradiation. Expression of TGF-β1, MMP-1 and MDA dermis observed by immunohistochemistry. The result showed that oral and topical therapy of C. asiatica extract was capable of inhibiting the increase of MMP-1 and MDA expression and the decrease of TGF- β1 significantly (p<0.05) in the dermal fibroblast of Wistar rat that exposed UVB light.
The Effect of Rice Bran Cereals on Total Cholesterol, Malondialdehyde (MDA) Levels and Histopathology Description of Aortic Organ on Mice Model of Hypercholesterolemia Dolly Irnawati Neno; Chanif Mahdi; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1070.652 KB) | DOI: 10.21776/ub.jpacr.2018.007.003.429

Abstract

Rice bran cereals could be used as the alternative treatment on hypercholesterolemia condition. Tocopherol as an antioxidant and dietary fiber as cellulose, hemicellulose, and lignin which contained in rice bran cereals have the potential to decrease total cholesteroland malondialdehyde levels. The aims of this study are to determine the role of rice bran cereals to decrease total cholesterol, malondialdehyde levels and improve the histopathologyof the aortic organ due to hypercholesterolemia. This study used rats (Rattus Norvegicus) as animals model which were divided into 5 groups: control group (healthy rats), hypercholesterolemia group (sick rat) and 3 therapy groups with variation dose respectively 270, 540 and 810 mg/kg body weight. Data analysis for total cholesterol and malondialdehyde levels used one-way ANOVA with α = 0.05 with Tukey test as a follow-up test. The results of statistical analysis proved that rice bran cereals with a dose of 810 mg/kg body weight effect for the changes of total cholesterol and malondialdehyde levels which are 21.72% and 50.88%, respectively. In addition, results showed that rice bran cereals therapy could significantly influence (p = 0.05) decrease of total cholesterol, malondialdehyde levels and improve the histopathology of an aortic organ in hypercholesterolemic rats.
Co-Authors Aulanni’am Aulanni’am Chanif Mahdi Dolly Irnawati Neno Yeny Diah Rahmawati