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Sutrisno Sutrisno
Chemistry Department, Brawijaya University
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity and Phytochemical Analysis of Edible Seaweed Eucheuma spinosum Against Staphyloccocus aureus Anna Safitri; Arie Srihardyastutie; Anna Roosdiana; Sutrisno Sutrisno
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1012.97 KB) | DOI: 10.21776/ub.jpacr.2018.007.03.389

Abstract

The current work aims to determine antibacterial activities of ethanol extracts of Eucheuma spinosum against Staphylococcus aureus. These were showed through inhibition zones formation, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) values. The MIC was determined using dilution test tube method, and the MBC was calculated using streaking method. Qualitative test was applied to determine phytochemical compounds in ethanol extract of E. spinosum. Results showed that ethanol extracts of E. spinosum at concentrations of 1%; 2%; 5%, and 10% (v/v) resulted in inhibition zones of 1.98; 4.14; 7.42; and 10.27 mm, respectively. In addition, concentration of 10% (v/v) was the MIC, and 15% (v/v) was the MBC values of E. spinosum extracts against S. aureus. The phytochemical analysis showed that alkaloids and saponins were the main components detected. Alkaloids positive tests were observed by the formation of brown sediment with Wagner’s reagent, yellow sediment with Mayer’s reagent, and orange sediment with Dragendorff’s reagent. Saponins positive results were detected by the formation of stable foam when the extracts reacted with water and HCl. Overall, these results suggested that E. spinosum extracts have antibacterial properties against Gram-positive bacteria, i.e. S. aureus. 
Synthesis Organonitrogen Compounds from Patchouli Alcohol Through Ritter Reaction with Acetonitrile and Its Toxicity to Artemia salina Leach. Khoirun Nisyak; Mohammad Farid Rahman; Sutrisno Sutrisno
The Journal of Pure and Applied Chemistry Research Vol 2, No 1 (2013)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.756 KB) | DOI: 10.21776/ub.jpacr.2013.002.01.113

Abstract

Patchouli oil contains a compound with biological activities to human body called the patchouli alcohol that can be further developed in medical field. This research aimed to synthesize organonitrogen compound from patchouli alcohol through Ritter reaction with acetonitrile and discover its toxicity towards Artemia salina Leach. The isolation of patchouli alcohol from patchouli oil using fractional distillation under reduced pressure method. The synthesis of organonitrogen compound is done at room temperature with the mol ratio of patchouli alcohol: acetonitrile: sulfuric acid is 1:1,5:4 for 24 hours. The result showed that the amount of patchouli alcohol produced from fractional distillation is 65,25%. The main product yielded from the synthesis between patchouli alcohol and acetonitrile through Ritter reaction is 36,93 % of N-(4,8a,9,9-tetramethyl decahydro-1,6-methanonaphtalene-1-yl) acetamide. Starting material used have LC50 of 77,39 ppm. The product of synthesis have higher toxicity level than starting material, which have LC50 value is 10,39 ppm with the potential as medical compounds.
Co-Authors Anna Roosdiana Arie Srihardyastutie Khoirun Nisyak Mohammad Farid Rahman Safitri, Anna