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All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ririn Puspadewi
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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ISOLASI MIKROBA TANAH YANG BERPOTENSI MENGHASILKAN ANTIMIKROBA Ririn Puspadewi; Rina Anugrah; Afif Abdulbasith; Intan Yunita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.304

Abstract

The soil is one of the habitats for microorganisms, in one gram soil there are millions of microorganism. Population microorganism per gram the rich soil of covering bacteria, actinomycetes, fungi, algae and protozoa. Garden having the potential to do exploration of isolation microorganisms. This is because land contains many organic compounds and minerals that is one ecosystem fertile to life and growth microorganisms. Whenever a microorganisms have proven produce substance antimicrobe so organisms of its potential as producer antibiotics. Material research the land, taken from the soil Faculty of Pharmacy Plant Garden of UNJANI, we did dilution and cultivated in a media potato dextrose broth. The isolate from medium broth was cultivating in a media potato dextrose agar, to obtained isolates single. Isolates obtained seen features macroscopic and microscopic. The results obtained isolates isolation two of the four isolates that can give inhibition to Escherichia coli but does not inhibition to Staphylococcus aureus. Keywords: isolation, microbe, soil
In-Silico Investigation of Compounds from Black Mangrove (Rhizophora mucronata L.) as Inhibitors of Exo-1,3-β-Glucanase in Candida albicans Ririn Puspadewi; Dadan Suryasaputra; Nurrohmana, Rizki
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26579

Abstract

Candida albicans is an opportunistic fungal pathogen responsible for systemic infections that result in considerable morbidity and mortality. The enzyme Exo-1,3 β-glucanase is essential for cell wall metabolism and pathogenicity in C. albicans, rendering it a potential therapeutic target. The study aims to evaluate the effectiveness of bioactive compounds from black mangroves (Rhizophora mucronata L.) as inhibitors of Exo-1,3 β-glucanase using an in silico approach. The test results from 28 black mangrove plant compounds yielded a the free energy value (ΔG) with a the inhibition constant (KI) comparable to that of ibrexafungerp. The four compounds exhibited the following properties: β-amyrin (ΔG) = -8.24 kcal/mol with KI = 908.46 nM, lupeol = -8.19 kcal/mol with KI = 994.44 nM, ethyl-iso allocholate = -7.66 kcal/mol with KI = 2.44 μM, and magnolol = -7.2 kcal/mol with KI = 5.25 μM. The molecular docking test results were evaluated from multiple perspectives, specifically the ΔG value generated post-docking, the KI, and the interactions of amino acid bonds and residues with the receptor. The ADMET prediction test results indicate that the four molecular docking test chemicals exhibit commendable skin penetrating capabilities. Based on the results of the tests, the four compounds, namely Ethyl-isoallocholate, β-amyrin, Magnolol, and Lupeol with β-amyrin, have the potential to become new drug candidates as Exo 1-3-(-glucanase inhibitors) in Candida albicans
In-Silico Investigation of Compounds from Black Mangrove (Rhizophora mucronata L.) as Inhibitors of Exo-1,3-β-Glucanase in Candida albicans Ririn Puspadewi; Dadan Suryasaputra; Nurrohmana, Rizki
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26579

Abstract

Candida albicans is an opportunistic fungal pathogen responsible for systemic infections that result in considerable morbidity and mortality. The enzyme Exo-1,3 β-glucanase is essential for cell wall metabolism and pathogenicity in C. albicans, rendering it a potential therapeutic target. The study aims to evaluate the effectiveness of bioactive compounds from black mangroves (Rhizophora mucronata L.) as inhibitors of Exo-1,3 β-glucanase using an in silico approach. The test results from 28 black mangrove plant compounds yielded a the free energy value (ΔG) with a the inhibition constant (KI) comparable to that of ibrexafungerp. The four compounds exhibited the following properties: β-amyrin (ΔG) = -8.24 kcal/mol with KI = 908.46 nM, lupeol = -8.19 kcal/mol with KI = 994.44 nM, ethyl-iso allocholate = -7.66 kcal/mol with KI = 2.44 μM, and magnolol = -7.2 kcal/mol with KI = 5.25 μM. The molecular docking test results were evaluated from multiple perspectives, specifically the ΔG value generated post-docking, the KI, and the interactions of amino acid bonds and residues with the receptor. The ADMET prediction test results indicate that the four molecular docking test chemicals exhibit commendable skin penetrating capabilities. Based on the results of the tests, the four compounds, namely Ethyl-isoallocholate, β-amyrin, Magnolol, and Lupeol with β-amyrin, have the potential to become new drug candidates as Exo 1-3-(-glucanase inhibitors) in Candida albicans
Co-Authors Afif Abdulbasith Dadan Suryasaputra Intan Yunita Nurrohmana, Rizki Rina Anugrah