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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Nautical: Jurnal Ilmiah Multidisiplin Indonesia Media Farmasi Indonesia Indonesian Journal of Medical and Pharmaceutical Science
Christina Indrajati
Bagian Ilmu Kesehatan Mata Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Effectiveness of Gentamicin and Chloramfenicol for Infant Dacryocistitis Indrajati, Christina; Handojo, Norma D.; Winarto, Winarto
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.452 KB) | DOI: 10.30659/sainsmed.v3i2.392

Abstract

Background: Dacryocistitis is an infection of lacrimal system due to blockage of Hasner valve by a membrane commonly found in infant. The management of dacryocistitis includes nasolacrimal massage and topical broad spectrum antibiotics since chloramfenicol and gentamicin are widely used in regional hospital primary health care in Indonesia, the effectiveness of the two antibiotics require an assessment. This study was conducted to compare the clinical and bacteriological effectiveness of gentamicin and chloramfenicol for infant dacryicistitis to describe the etiologic bacterial and its sensitivity pattern.Design and Method: A randomized control trial study included 46 patients divided equally into two groups. Group K received one drop chloramfenicol six times per day and group G receive one drop gentamicin six times per day. Both of groups received therapy for 14 days. Clinical evaluation was done on week I and week II. Microbiological evaluation was performed before treatment and at the end of week two. Criteria for clinical recovery were the disappearance of the sign and symptoms of dacryocistitis, while microbiologic recovery ruled out when there is no bacteria find out on secret and lacrimal system. Antibiotics eye drop was applied after digital massage on lacrimal system and clean the secret. Grams staining, bacterial culture and sensitivity test were performed in microbiology laboratory.Result: Clinical and microbiological recovery for chloramfenicol and gentamicin were 43.5% (p = 0.832) and 52.2% (p = 0.670) respectively. The most frequent bacteria on infant dacryocistitis were Staphylococcus aureus (45.7%) followed by Pseudomonas (21.7%), Enterobacter sp (17.4%), Escherichia coli (10.9%) and Staphylococcus epidermidis (4.3%). The sensitivity of bacteria against chloramfenicol and gentamicin was Staphylococcus aureus 57.1%, Pseudomonas aeruginosa 50%, Enterobacter sp 87.5%, Escherichia coli 40% and Staphylococcus epidermidis 100%.Conclusion: There is no significant different between chloramfenicol and gentamicin in dacryocistitis (Sains Medika, 3(2):105-111).
Corneal edema after cataract surgery in diabetic and non-diabetic patients Indrajati, Christina; Rahmawati, Atik; Mahardika, Nabila Ayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.34177

Abstract

Patients with diabetes mellitus undergoing phacoemulsification cataract surgery face an elevated risk of corneal edema, primarily due to metabolic disturbances that impair endothelial cell function, leading to delayed post-operative recovery. This prospective cohort study aimed to examine the relationship between diabetes mellitus and the incidence of corneal edema following phacoemulsification. A total of 180 cataract patients scheduled for surgery at Sultan Agung Eye Center, Semarang, and Dr. R. Soedjati Soemodiardjo Regional Public Hospital, Purwodadi, Indonesia, between July and August 2023, were enrolled. Participants were divided into two groups based on the presence or absence of diabetes mellitus. Corneal edema and visual acuity were evaluated on post-operative days 1 and 7. Statistical analyses assessed the association between diabetes mellitus and post-operative corneal edema, with a significance threshold set at p < 0.05. The results indicated that pre-operative visual impairment was significantly worse in non-diabetic patients compared to diabetic patients (p = 0.000). However, post-operative visual improvement was significantly greater in non-diabetic patients on both day 1 (p = 0.02) and day 7 (p = 0.00) compared to diabetic patients. Additionally, the incidence of corneal edema was significantly higher among diabetic patients on both day 1 (p = 0.004) and day 7 (p = 0.001) post-surgery. These findings suggest that diabetes mellitus is associated with a higher risk of corneal edema and delayed visual recovery following phacoemulsification cataract surgery.
Perbandingan efektifitas pijatan sakus lakrimal dengan kombinasi sakus dan duktus lakrimal pada dakriostenosis kongenital Indrajati, Christina; Widiyanto, Bagas
Nautical : Jurnal Ilmiah Multidisiplin Indonesia Vol. 2 No. 11 (2024): Nautical: Jurnal Ilmiah Multidisiplin Indonesia
Publisher : ARKA INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55904/nautical.v2i11.606

Abstract

Dacryostenosis congenital adalah penyakit yang umum terjadi pada bayi baru lahir dengan angka kejadian sekitar 1-6% dari seluruh bayi bari lahir dan pada fase selanjutnya akan menyebabkan infeksi. Pijatan pada sakus lakrimal merupakan pilihan terapi sederhana dan dilaporkan cukup efektif. Modifikasi teknik pijatan menjadi tujuan peneltian ini, yaitu membandingkan efektifitas teknik pijatan kombinasi pada sakus dan ductus nasolakrimal dengan teknik pijatan pada sakus nasolacrimal. Jumlah sampel penelitian 55 bayi dengan rentang usia 1-10 bulan dan didiagnosa dacryostenosis congenital, sembuh dengan 2 teknik pijatan yang dibandingkan dalam waktu sekitar 12 minggu. Hasil perhitungan statistik efektifitas teknik pijatan saccus lakrimal dibandingkan dengan teknik pijatan kombinasi sakus dan duktus lakrimal tidak memiliki perbedaan yang bermakna p = 0,95 (p>0,05). Namun demikian untuk teknik pijatan kombinasi secara klinis lebih cepat dalam resolusi spontan yaitu dimulai minggu ke 3. Teknik pijatan pada sakus nasolakirmal dan teknik pijatan kombinasi pada sakus dan ductus merupakan pilihan pertama dan sederhana untuk penanganan awal Dacryostenosis Congenital.
Gambaran Kasus Entropion Involusional di Sultan Agung Eye Center (SEC) Rumah Sakit Islam Sultan Agung Semarang Tahun 2008-2018 INDRAJATI, Christina; WIDIYANTO, Bagas
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.521 KB) | DOI: 10.53359/mfi.v15i2.160

Abstract

Involutional entropion is an eye disorder that often occurs because of the aging process. The most severe complication of this case is the permanent decrease in vision caused by corneal damage due to friction of the eyelid. This study aims to provide an overview of involutional entropion at the SEC Sultan Agung Islamic Hospital Semarang. The research method used was descriptive observational. Research subjects were 69 patients diagnosed with involutional entropion from January 2008 until January 2018. 69 research subjects were used, divided into several characteristics. Gender, 36.2% males, and 63.8% female. Age group, <60 years 31.9% and> 60 years 68.1%. The location of the eyelids, the upper eyelid 40.6%, and the lower eyelid 59.4%. Operating techniques, ALR (Anterior Lamelar Reposition) 40.6%, Everting Suture technique 29.0%, Weis technique 30.4%. Results of surgery recovered 86.2% and recurring 13.8%.
Efficacy of 5% Sodium Chloride Therapy in Reducing Corneal Oedema After Phacoemulsification Cataract Surgery Indrajati, Christina; Rahmawati, Atik; Suparmi, Suparmi
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 2 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i2.425

Abstract

Background: Cataract surgery using the phacoemulsification technique often results in postoperative corneal oedema, which impairs visual acuity and reduces patient satisfaction. This study aims to evaluate the efficacy of 5% sodium chloride eye drops as an initial management for postoperative corneal oedema following phacoemulsification. Methods: This double-blind, multicenter randomised controlled trial involved 228 patients with senile cataracts scheduled for phacoemulsification cataract surgery performed by a single experienced ophthalmologist. Patients underwent preoperative screening and were monitored on days 3 and 10 post-surgery. Visual acuity was measured using Snellen charts, and corneal oedema was clinically assessed with slit-lamp examination. Results: On day 3 post-surgery, the group treated with 5% sodium chloride demonstrated significantly better visual acuity than the control group (p=0.000). By day 10, no significant difference in visual acuity was observed between groups (p=0.413). Additionally, the incidence of corneal oedema was significantly lower in the sodium chloride group on days 3 and 10 (p=0.000). Conclusion: Topical 5% sodium chloride effectively reduces corneal oedema after phacoemulsification, resulting in clinical improvement and better early postoperative visual acuity.
Perbandingan efektifitas pijatan sakus lakrimal dengan kombinasi sakus dan duktus lakrimal pada dakriostenosis kongenital Indrajati, Christina; Widiyanto, Bagas
Nautical : Jurnal Ilmiah Multidisiplin Indonesia Vol. 2 No. 11 (2024): Nautical: Jurnal Ilmiah Multidisiplin Indonesia
Publisher : ARKA INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55904/nautical.v2i11.606

Abstract

Dacryostenosis congenital adalah penyakit yang umum terjadi pada bayi baru lahir dengan angka kejadian sekitar 1-6% dari seluruh bayi bari lahir dan pada fase selanjutnya akan menyebabkan infeksi. Pijatan pada sakus lakrimal merupakan pilihan terapi sederhana dan dilaporkan cukup efektif. Modifikasi teknik pijatan menjadi tujuan peneltian ini, yaitu membandingkan efektifitas teknik pijatan kombinasi pada sakus dan ductus nasolakrimal dengan teknik pijatan pada sakus nasolacrimal. Jumlah sampel penelitian 55 bayi dengan rentang usia 1-10 bulan dan didiagnosa dacryostenosis congenital, sembuh dengan 2 teknik pijatan yang dibandingkan dalam waktu sekitar 12 minggu. Hasil perhitungan statistik efektifitas teknik pijatan saccus lakrimal dibandingkan dengan teknik pijatan kombinasi sakus dan duktus lakrimal tidak memiliki perbedaan yang bermakna p = 0,95 (p>0,05). Namun demikian untuk teknik pijatan kombinasi secara klinis lebih cepat dalam resolusi spontan yaitu dimulai minggu ke 3. Teknik pijatan pada sakus nasolakirmal dan teknik pijatan kombinasi pada sakus dan ductus merupakan pilihan pertama dan sederhana untuk penanganan awal Dacryostenosis Congenital.
Co-Authors Atik Rahmawati Bagas Widiyanto, Bagas Mahardika, Nabila Ayu Norma D. Handojo Suparmi Suparmi Winarto Winarto