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Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension Hussaana, Atina; Sarosa, Hadi; Indrayani, Ulfah Dian; Chodidjah, Chodidjah; Widiyanto, Bagas; Pertiwi, Danis
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.81-88

BACKGROUNDHypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. METHODSThis double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.RESULTSThe results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05). CONCLUSIONFrom this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.

The Effectiveness of Learning Methods by Measuring Accuracy and Rationality in Prescription Writing by Medical Students Widiyanto, Bagas; Riza, Muhamad
Journal of Health Policy and Management Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.042 KB)

Background: Writing prescriptions accurately and rationally is a competency that must be achieved by medical students during medical education. This capability includes detailed knowledge of the components of the recipe and details of the components of the drug. This study aims to determine the description of the prescription writing practicum learning method carried out in the Pharmacology section of Faculty of Medicine in Unissula.Subjects and Method: This research is a descriptive study by looking at the prettest and posttest values. It was conducted in March 2020. The subjects of this study were 159 students who were registered participants of the psychiatry module in semester 6 in the undergraduate medical education study program at Faculty of Medicine in Unissula. 159 students were randomly divided into 20 SGD (Small Group Discussion), batch 1 SGD 1-10 and SGD 11-20 in batch 2. Each batch carried out practicum for 100 minutes. The activity begins with a pretest / giving case scenarios, then the discussion and discussion session ends with a posttest. The data in this study are numerical data and analyzed descriptively.Results: The results of the study indicated that the improvement across categories and those assessed was both the detailed component of the recipe and the detail component of the drug. The detail component of the prescription had the highest score increase in the patient name category by 27% higher posttest than pretest. In the detail component of the prescription, there was the highest increase in the category of Sedian Medicine (BSO) by 20.7% and that was a higher posttest value when compared to the pretest value.Conclusion: Clinical-based special learning methods with small class discussions are needed in an effort to improve the ability to write prescriptions appropriately and rationally by adjusting the level of education years.Keywords: prescription, rational, medical studentCorrespondence: Bagas Widiyanto. Department of Pharmacology, Faculty of Medicine, Universitas Islam Sultan Agung. Jl. Raya Kaligawe KM. 4, Semarang 1054, Ccentral Java, Indonesia. Email: bagaswidiyanto@unissula.ac.idJournal of Health Policy and Management (2021), 06(01): 74-80https://doi.org/10.26911/thejhpm.2021.06.01.08

Pengembangan dan Inovasi Produk Kerupuk Petulo untuk Meningkatkan Daya Saing Usaha Mikro Ardianto, Widi; Purnomo, Aditya Noer Hefdi; Widiyanto, Bagas; Fikri, Kamil; Maulidya, Hafidhah Riska; Sari, Yuni Novita; Azhari, Ayu; Ahmad, Alifian Rizzalul; Mayasiana, Nur Aini
Majalah Ilmiah "PELITA ILMU" Vol 7 No 1 (2024): PELITA ILMU (JUNI 2024)
Publisher : STIA Pembangunan Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37849/mipi.v7i1.400

Pelaksanaan kegiatan pengabdian kepada masyarakat ini ditujukan kepada usaha mikro kerupuk petulo milik ibu er di Dusun Darungan Desa Cangkring Kecamatan Jenggawah Kabupaten Jember. Usaha ini didirikan sejak tahun 2003 yang pada artinya sudah berjalan sekitar 20 tahun. Namun tidak ada label usaha dan kemasan produk hanya menggunakan kantong kresek. Pelaksanaan kegiatan dimulai bulan Oktober sampai dengan Desember 2023 di usaha mikro kerupuk petulo milik ibu istri atau lebih dikenal dengan Ibu Er. Kegiatan ini melibatkan 6 mahasiswa dari Program Studi Ilmu Administrasi Niaga. Metode kegiatan yang dilaksanakan yaitu pengembangan dan inovasi kemasan produk kerupuk petulo, pemberian lebel usaha. Tujuan kegiatan adalah guna meningkatkan daya saing usaha mikro kerupuk petulo milik Ibu Er. Hasil usaha ini adalah Ibu Er sudah mengetahui tentang pengembangan dan inovasi produk.

PENGARUH EKSTRAK BUNGA TELANG (CLITORIA TERNATE L) TERHADAP KADAR SGOT Pratami, Rani Windasari; Widiyanto, Bagas; Trisnadi, Reza Adityas; ., Chodidjah; Silviana, Meyvita
Jurnal Ilmiah Penelitian Mahasiswa Vol 3, No 1 (2024): Maret 2024
Publisher : Jurnal Ilmiah Sultan Agung

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Kerusakan hati merupakan proses terjadinya nekrosis pada sel hati yang dapat disebabkan karena Drug Induced Liver Injury (DILI) akibat penggunaan parasetamol berlebih sehingga menyebabkan naiknya kadar Serum Glutamic-Oxaloacetic Transaminase (SGOT) dalam darah. Bunga telang (Clithoria Ternatea) merupakan tanaman yang salah satunya mengandung flavonoid dengan kandungan tinggi antioksidan sehingga berguna sebagai hepatoprotektor untuk menurunkan kadar SGOT darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bunga telang terhadap kadar SGOT pada tikus putih jantan galur wistar. Penelitian eksperimental dengan rancangan post test only control group design ini dilakukan selama dua minggu dan melibatkan 28 sampel yang telah memenuhi kriteria inklusi dan eksklusi. Penelitian ini dibagi menajdi 4 kelompok secara random. Data kadar SGOT diperoleh dari penelitian di Laboratorium Pusat Studi Pangan dan Gizi Yogyakarta. Hasil rerata kadar SGOT darah yaitu KN 36,76 ± 0,87 U/l, KS 77,82 ± 0,96 U/l, KP1 51,95 ± 1,05 U/l, dan KP2 40,16 ± 0,87 U/l. Data tersebut dianalisis dengan uji Kruskal wallis dan Mann-whitney. Hasil dari analisis uji Kruskal wallis yaitu terdapat perbedaan bermakna rerata kadar SGOT dengan nilai p = 0,000 (p<0,05). Selanjutnya didapatkan juga perbedaan bermakna rerata kadar SGOT antar kelompok penelitian yang signifikan dengan nilai p = 0,002 (p<0,05).Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak bunga telang berpengaruh terhadap kadar SGOT pada tikus putih jantan galur wistar yang diinduksi parasetamol.Kata Kunci: ekstrak bunga telang, kadar SGOT

Perbandingan efektifitas pijatan sakus lakrimal dengan kombinasi sakus dan duktus lakrimal pada dakriostenosis kongenital Indrajati, Christina; Widiyanto, Bagas
Nautical : Jurnal Ilmiah Multidisiplin Indonesia Vol. 2 No. 11 (2024): Nautical: Jurnal Ilmiah Multidisiplin Indonesia
Publisher : ARKA INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55904/nautical.v2i11.606

Dacryostenosis congenital adalah penyakit yang umum terjadi pada bayi baru lahir dengan angka kejadian sekitar 1-6% dari seluruh bayi bari lahir dan pada fase selanjutnya akan menyebabkan infeksi. Pijatan pada sakus lakrimal merupakan pilihan terapi sederhana dan dilaporkan cukup efektif. Modifikasi teknik pijatan menjadi tujuan peneltian ini, yaitu membandingkan efektifitas teknik pijatan kombinasi pada sakus dan ductus nasolakrimal dengan teknik pijatan pada sakus nasolacrimal. Jumlah sampel penelitian 55 bayi dengan rentang usia 1-10 bulan dan didiagnosa dacryostenosis congenital, sembuh dengan 2 teknik pijatan yang dibandingkan dalam waktu sekitar 12 minggu. Hasil perhitungan statistik efektifitas teknik pijatan saccus lakrimal dibandingkan dengan teknik pijatan kombinasi sakus dan duktus lakrimal tidak memiliki perbedaan yang bermakna p = 0,95 (p>0,05). Namun demikian untuk teknik pijatan kombinasi secara klinis lebih cepat dalam resolusi spontan yaitu dimulai minggu ke 3. Teknik pijatan pada sakus nasolakirmal dan teknik pijatan kombinasi pada sakus dan ductus merupakan pilihan pertama dan sederhana untuk penanganan awal Dacryostenosis Congenital.

Gambaran Kasus Entropion Involusional di Sultan Agung Eye Center (SEC) Rumah Sakit Islam Sultan Agung Semarang Tahun 2008-2018 INDRAJATI, Christina; WIDIYANTO, Bagas
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Involutional entropion is an eye disorder that often occurs because of the aging process. The most severe complication of this case is the permanent decrease in vision caused by corneal damage due to friction of the eyelid. This study aims to provide an overview of involutional entropion at the SEC Sultan Agung Islamic Hospital Semarang. The research method used was descriptive observational. Research subjects were 69 patients diagnosed with involutional entropion from January 2008 until January 2018. 69 research subjects were used, divided into several characteristics. Gender, 36.2% males, and 63.8% female. Age group, <60 years 31.9% and> 60 years 68.1%. The location of the eyelids, the upper eyelid 40.6%, and the lower eyelid 59.4%. Operating techniques, ALR (Anterior Lamelar Reposition) 40.6%, Everting Suture technique 29.0%, Weis technique 30.4%. Results of surgery recovered 86.2% and recurring 13.8%.

Efek Anti Inflamasi Ekstrak Daun Salam (Syzygium Polyanthum) Widiyanto, Bagas; Sampurna, Sampurna; Rizki Dewinda Putri, Cantika; Adiba Aysar, Nisrina; Brave Sinatrya, Muhamad
Jurnal sosial dan sains Vol. 5 No. 8 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i8.32451

Inflammation or inflammation is characterized by increased levels of pro-inflammatory mediators such as IL6, IL1, TNF- and CRP proteins in the blood. One of the mechanisms is through the activation of TLR-4 and NF-κB. Natural remedies have developed, one of which is using bay leaves (Syzygium polyanthum). Bay leaves contain flavonoids, tannins, and saponins that have the potential to be anti-inflammatory. This study aimed to determine the effect of bay leaf extract on IL-6, IL-1, TNF- and CRP protein levels in male white rats of wistar strain induced by 1% carrageenan. Methods: An experimental type of research with a "post test only control group design" design with a research sample of 24 male white rats of the wistar strain, divided into 4 groups randomly. The healthy control group (Knormal), the sick group (Kneg) with 1% carrageenan induction, treatment 1 (K1) was given bay leaf extract 100mg/kgBB, treatment 2 (K2) was given bay leaf extract 200 mg/kgBB. After that, IL-6, IL-1, TNF- and CRP protein levels were checked using ELISA. The data was analyzed using the One Way Anova test followed by the Post Hoc LSD test. Results: The treatment group, namely the administration of bay leaf extract at doses of 100 mg/kgBB (K1) and 200 mg/kgBB (K2), was lower than Kneg and significantly different (p<0.05) in all experimental parameters. The average levels of IL-6, IL-1, TNF- , CRP in the K2 group were lower than in the K1 group. Based on the data above, the dose of bay leaf extract of 200 mgKgBB has better potential as an anti-inflammatory. Conclusion: bay leaf extract has an effect on IL-6, IL-1, TNF-, CRP levels

Perbandingan efektifitas pijatan sakus lakrimal dengan kombinasi sakus dan duktus lakrimal pada dakriostenosis kongenital Indrajati, Christina; Widiyanto, Bagas
Nautical : Jurnal Ilmiah Multidisiplin Indonesia Vol. 2 No. 11 (2024): Nautical: Jurnal Ilmiah Multidisiplin Indonesia
Publisher : ARKA INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55904/nautical.v2i11.606

Dacryostenosis congenital adalah penyakit yang umum terjadi pada bayi baru lahir dengan angka kejadian sekitar 1-6% dari seluruh bayi bari lahir dan pada fase selanjutnya akan menyebabkan infeksi. Pijatan pada sakus lakrimal merupakan pilihan terapi sederhana dan dilaporkan cukup efektif. Modifikasi teknik pijatan menjadi tujuan peneltian ini, yaitu membandingkan efektifitas teknik pijatan kombinasi pada sakus dan ductus nasolakrimal dengan teknik pijatan pada sakus nasolacrimal. Jumlah sampel penelitian 55 bayi dengan rentang usia 1-10 bulan dan didiagnosa dacryostenosis congenital, sembuh dengan 2 teknik pijatan yang dibandingkan dalam waktu sekitar 12 minggu. Hasil perhitungan statistik efektifitas teknik pijatan saccus lakrimal dibandingkan dengan teknik pijatan kombinasi sakus dan duktus lakrimal tidak memiliki perbedaan yang bermakna p = 0,95 (p>0,05). Namun demikian untuk teknik pijatan kombinasi secara klinis lebih cepat dalam resolusi spontan yaitu dimulai minggu ke 3. Teknik pijatan pada sakus nasolakirmal dan teknik pijatan kombinasi pada sakus dan ductus merupakan pilihan pertama dan sederhana untuk penanganan awal Dacryostenosis Congenital.

Pengaruh Krim Ekstrak Clitoriaternatea terhadap Jumlah Neutrofil Kulit yang Dipapar Sinar Ultra Violet B Purnamasari, Rina; Widiyanto, Bagas
MAHESA : Malahayati Health Student Journal Vol 3, No 10 (2023): Volume 3 Nomor 10 (2023)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v3i10.11189

ABSTRACT Ultraviolet B radiation can cause photodamage to the skin. Clitoria ternatea is one of the natural ingredients that contains flavonoids which can use as anti-inflammatory due to UV B light exposure. This research uses a randomized post-test only control group design. The sample use 25 male wistar rats were divided into 5 groups, the normal control group, the negative control group which received UV B light exposure, the positive control group which received UV B light exposure and SPF 30 sunscreen, the P1 group which received UV B light exposure and extract cream. Clitoria ternate dose of 2.5%, group P2 received exposure to UV B light and Clitoria ternate extract cream dose of 5%. The number of neutrophils was observed by staining with hematoxylin eosin, under a light microscope with a magnification of 200x. Data were analyzed by Kruskall Wallis with the Mann Whitney Post Hoc Test. The highest average number of neutrophils was found in the negative control group (1.24 ± 1.69), while the lowest average value shown by the normal control group (0 ± 0). TheKruskall Wallis test ha p<0.05, which means there was a significant difference between groups. The results of the Mann-Whitney Post Hoc Test showed a value of p <0.05 between normal control group with negative controls, P1 and P2; negative control with positive control, P1 and P2. While the value of P> 0.05, which means there is no significant difference between the two groups shown in the normal control group with positive control, positive control with P1 and P2; group P1 with P2. From the results of this study can be concluded that Clitoriaternatea extract cream has an effect on the number of neutrophils exposed to ultra violet B rays. Keywords: Anti-Inflammatory, Clitoria Ternatea, Neutrophils, Ultra Violet ABSTRAK Radiasi sinar ultra violet (UV) B memiliki dampak photodamage pada kulit. Clitoria ternatea salah satu bahan alam yang memiliki kandungan flavonoid yang dapat berperan sebagai antiinflamasi akibat paparan sinar UV B. Penelitian ini menggunakan randomized post-test only control grup design. Sampel sebanyak 25 ekor tikus jantan galur wistar yang dibagai dalam 5 kelompok yaitu yaitu kelompok kontrol normal, kelompok kontrol negatif yang mendapat paparan Sinar UV B, kelompok kontrol positif mendapat paparan Sinar UV B dan tabir surya SPF 30, kelompok P1 mendapat paparan Sinar UV dan krim ekstrak Clitoria ternate dosis 2,5%, kelompok P2 mendapat paparan Sinar UV B dan krim ekstrak Clitoria ternate dosis 5%. Jumlah neutrofil diamati dengan pengecatan hematoksilin eosin, dibawah mikroskop cahaya perbesaran 200x. Data dianalisis dengan Kruskall Wallis dengan Post Hoc Test Mann Whitney. Rata-rata jumlah neutrofil tertinggi terdapat pada kelompok kontrol negatif (1.24 ± 1.69), sedangkan nilai rerata terendah ditunjukkan oleh kelompok kontrol normal (0 ± 0). Hasil uji Kruskall Wallis didapatkan nilai p<0.05 yang berarti terdapat perbedaan secara signifikan antar kelompok. Hasil uji Post Hoc Test Mann-Whitney didapatkan nilai P<0.05 pada kelompok kontrol normal dengan kontrol negatif, P1 dan P2; kontrol negatif dengan kontrol positif, P1 dan P2. Sedangkan nilai P>0.05 yang berarti tidak terdapat perbedaan signifkan antar dua kelompok ditunjukkan pada kelompok kontrol normal dengan kontrol positif, kontrol positif dengan P1 dan P2; kelompok P1 dengan P2. Dari hasil penelitian dapat disimpulkan bahwa krim ekstrak Clitoriaternatea berpengaruh terhadap jumlah neutrofil yang dipapar sinar ultra violet B. Kata Kunci: Antiinflamasi, Clitoria Ternatea, Neutrofil, Ultra Violet

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