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Eksisi Mucocele Rekuren pada Ventral Lidah dengan Anestesi Lokal Dody Setiawan; Bambang Dwirahardjo; Elizabeth Titi Riyati Astuti
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 2, No 1 (2016)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Mucocele adalah lesi yang umum ditemukan pada mukosa oral dan merupakan lesi jinak kelenjar saliva yang paling sering ditemukan di rongga mulut. Insiden mucocele sering ditemukan karena adanya trauma kelenjar saliva minor. Mucocele dapat terjadi laki-laki maupun perempuan pada segala usia dengan insiden tertinggi pada dekade kedua. Mucocele dapat terjadi pada daerah manapun di dalam rongga mulut yang mengandung kelenjar saliva minor, tetapi bibir bawah merupakan lokasi paling umum karena paling mudah mengalami trauma. Mucocele Blandin Nuhn adalah mucocele yang paling sering terjadi pada lidah, meskipun jarang terjadi. Dilaporkan kasus mucocele Blandin Nuhn pada ventral lidah yang terjadi pada anak laki-laki 17 tahun, datang ke poli Bedah Mulut dan Maksilofasial RSUP Dr Sardjito, dengan riwayat rekurensi dimana sebelumnya 3 bulan yang lalu telah dilakukan eksisi lesi yang sama pada tempat yang sama. Penatalaksanaan pada kasus ini adalah insisi sekitar lesi bentuk ellip, lalu dilakukan deseksi hingga eksisi kelenjar saliva yang terlibat dengan anestesi lokal disertai motivasi terhadap pasien agar tidak menggangu bekas luka. Setelah dilakukan kontrol 6 bulan dengan hasil baik dan tidak ditemukan keluhan yang samaAbstract: Excision of recurent mucoceles at ventral of tongue under local anesthesia. Mucoceles are one of the most common of the benign soft tissue masses that occur in the oral cavity. Trauma to the minor salivary gland assosiated with insidens of mucocele. It belived to arise equally in both sexes and affect patients of all ages, with higher incidence in the second decade. Mucoceles could be happen anywhere in of oral cavity with minor salivary gland but the most common site is lower lip. Mucocele Blandin Nuhn is most common mucocele of tongue, even it rare case. We reported a 17 years old boy who came to Oral and Maxillofacial Surgery departement of RSUP Dr Sardjito hospital with mucocele Blandin Nuhn of ventral tongue, and recurent have been happen that 3 mouth before the lesion at same site had excisied. Treatment consists of reexcision with ellip incision, desection and excision of the assosiated salivary gland tissue beneath the mucocele with local anasthesia, and patient motivations do not disturb the lesion. Evaluation 6 mounths post surgery show good result and no sign of recurency.

Tooth exposure using closed eruption modification techniques in orthodontic treatment in postgnatoplasty patients Miftah Dharma Yanthi; Cahya Yustisia Hasan; Bambang Dwirahardjo
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 3, No 2 (2017)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.54470

Cleft lip, alveolar cleft, and cleft palate are the most common disorder of all congenital abnormalities of the face, with an incidence of 65%. The initial treatment for this patient are labioplasty and palatoplasty that can affect the growth and development of the jaws. The next treatment are alveolar cleft closure and orthodontics treatment that are needed to obtain optimal results. Orthodontics treatment of patient with cleft lip, alveolar cleft, and cleft palate is difficult due to the lack of growth in the vertical and anteroposterior direction, abnormal shape and position of the teeth, impacted and disability of the teeth to erupt spontaneously. Thus, surgical treatment to support the success of orthodontics treatment is needed. Twelve year old female patient with a history of cleft lip, alveolar cleft, and cleft palate was presented. A labioplasty, palatoplasty, and gnatoplasty surgery (alveolar cleft closure procedure) was performed in 2013, when a bone graft from the patients’ iliac bone was placed on the alveolar cleft area. Radiographic examination showed transposition of canine (23) with premolar (24) thus spontaneous eruption was impossible. Surgical intervention of tooth exposure using closed technique modification to move the canine into the expected place was performed. The canine was successfully erupted and moved to its mesial position. This predictable result was found 6 months after surgery

Effects of contact time of natural cu-zeolite on the growth of Streptococcus pyogenes and Pseudomonas aeruginosa Erwid Fatchur Rahman; Bambang Dwirahardjo; Poerwati Soetji Rahajoe
Majalah Kedokteran Gigi Indonesia Vol 6, No 1 (2020): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.40566

Infection of a surgical wound due to bacteria is a major problem for surgical patients. Cu-zeolite is a material that can suppress bacterial growth with reversible cation characteristics and adsorption to be developed into non-toxic disinfectants for humans. Packaging uses filter paper to keep disinfectant solutions or instruments that will be sterilized clean. This study aimed to observe the effects of contact time of natural Cu-zeolite on the growth of Streptococcus pyogenes (S. pyogenes) and Pseudomonas aeruginosa (P. aeruginosa) bacteria. An experimental research was simple randomized design. Cu-zeolite 10 grams were packaged in Whatman no 42 paper bags measuring 5 x 5 cm2, contacted for 15, 30 and 45 minutes in 99.5 ml of distilled water exposed to 0.5 x 108 CFU / ml of S. pyogenes and P. aeruginosa. Subsequently, bacterial growth was calculated using total plate count method. The average growth of S.pyogenes for 15, 30 and 45 minutes (1840 ± 571.236 CFU; 29 ± 16.33 CFU and 0 CFU) while P. aeruginosa was (2776 ± 725.277 CFU; 55 ± 23.214 CFU and 0 CFU) respectively. Based on the independent t-test on Cu-zeolite, the bacterial growth in the 15th and 30th minute contact between S. pyogenes and P. aeruginosa was significantly different (pth and 30th minute contact.

Sandwich Bone Augmentation (SBA) in immediate implant placement post dentoalveolar trauma: a case report Anton Anton; Poerwati S. Rahajoe; Bambang Dwirahardjo
Journal of Dentomaxillofacial Science Vol. 2 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v2i3.643

Objective: Reporting the application of SBA procedure with titanium mesh as an alternative solution for immediate implant placement in socket with dentoalveolar trauma-induced buccal bone defect.Methods: An 18-year-old female patient visited our department, with a history dentoalveolar trauma and a loss of Â tooth 21. Clinical examination during the implant placement procedure exposed Â a socket with buccal bone defect. SBA with autogenous chin bone graft combined with DFDBA allograft and stabilized with titanium mesh (Ti-Mesh) for buccal defect on which flap reposition was done with tension free primary closure.Results: Ti-Mesh was removed after 3 months which no sign of inflamation appeared, implant was in a stable condition and new bone formation was observed. Subsequently, healing abutment was placed. A one-year observation suggested a good clinical retention with no luxation observed, along with decent functional and esthetic results. CBCT evaluation showed buccal bone thickness preserved.Conclusion: Sandwich bone augmentation with stabilized titanium mesh provides a satisfying result in treating horizontal buccal bone defect.

Effect of low intensity pulse ultrasound on the neutrophil function and epithelial thickness after skin excision in diabetes mellitus type 2 rats’ model (an immunohistochemistry study on matrix metalloproteinase-9) Titis Laraswati; Cahya Y. Hasan; Bambang Dwirahardjo
Journal of Dentomaxillofacial Science Vol. 6 No. 1 (2021): (Available online: 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v6i1.1035

Objective: To determine the effect of Low Intensity Pulse Ultrasound (LIPUS) on the neutrophil function and epithelial thickness after skin excision in diabetes mellitus type 2 rats’ model (an Immunohistochemistry Study on Matrix Metalloproteinase-9).Material and Methods: Thirty-six Sprague dawley rats were divided into six groups: DM2, DM4, DM7, DML2, DML4, and DML7, each of which consist of 6 rats. Rats that matched the inclusion criteria were made into diabetes mellitus type 2 by injecting Nicotinamide and Streptozotocin. In all rat’s excision wound was made with punch biopsy in the back area. DML group received LIPUS therapy in the wound area (frequency: 3 MHz, intensity: 0.5 W/cm2, duty cycle: 20%, duration: 3 minutes every day) for two days (DML2), four days (DML4) and seven days (DML7). In the wound tissue an immunohistochemical examination was performed with Polyclonal Antibody MMP-9 to observe MMP-9 expression and and Periodic Acid-Schiff staining to observe epithelial thickness.Results: Two-Way ANOVA and Post-Hoc LSD test showed lower level of MMP-9 expressions in the DML group than in the DM group, whereas the epithelial thickness in the DML group was found higher than in the DM group. The Pearson test showed a correlation between the level of MMP-9 expressions and epithelial thickness (p=0.000; r=-0.785).Conclusion: LIPUS therapy reduced MMP-9 expression and increases epithelial thickness.

Effect of low-intensity pulsed ultrasound on mast cell degranulation and fibroblast expression on type 2 diabetes mellitus rats wound healing process Intan Maharani; Cahya Yustisia Hasan; Bambang Dwirahardjo; Tri Wahyu Pangestiningsih
Majalah Kedokteran Gigi Indonesia Vol 7, No 2 (2021): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.59132

Impaired wound healing is one of the Diabetes mellitus complications. Low-intensity Pulsed Ultrasound (LIPUS) therapy may accelerate the impaired wound healing. The use of LIPUS therapy in the early inflammatory phase can induce mast cell degranulation, and in the proliferative phase it can increase collagen synthesis by fibroblasts. The purpose of this study was to determine the effects of LIPUS therapy on mast cell degranulation and fibroblastexpression in the healing process of punch biopsy wound in rats with type 2 diabetes mellitus. Twenty-four Sprague dawley (n=24) were designed into type 2 diabetes mellitus by injecting Nicotinamide and Streptozotocin, then divided into six groups: diabetes mellitus without LIPUS (DM3, DM7, DM14) and diabetes mellitus with LIPUS (DML3, DML7, DML14), 4 each, and punch biopsy wounds were made on the dorsal skin. The DML group received LIPUS therapy in the wound area (frequency 3 MHz, intensity 0.5 W/cm2, duty cycle 20%, duration 3 minutes every day for 3 days (DML3), 7 days (DML7), and 14 days (DML14). The wounded tissue area was stained with toluidine blue to observe mast cell degranulation and immunohistochemical type HSP-47 to observe fibroblast expression. Two-Way ANOVA and Post Hoc LSD tests were used to determine the differences in mast cell degranulation and fibroblast expression. The results showed that mast cell degranulation and fibroblast expression in the DML group were higher than in the DM group (table 1). Pearson test showed a correlation between mast cell degranulation and fibroblast expression (p=0.00; r= 0.839). LIPUS therapy increases mast cell degranulation and fibroblast expression in type 2 diabetes mellitus rat model. The higher the mast cell degranulation, the higher fibroblast expressions.

PERAWATAN FIBROUS DYSPLASIA MAKSILA DEXTRA ANTERIOR PADA ANAK USIA 5 TAHUN Eviwati Sitanggang; Bambang Dwirahardjo; Cahya Yustisia Hasan
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 2, Nomor 2, Desember 2015
Publisher : Universitas Baiturrahmah

Introduction: The Management of Anterior Maxillaris Dextra Fybrous Dysplasia at the 5 years old patient. Fibrous dysplasia is an abnormal bone growth where normal bone is replaced with fibrous connective tissue intermixed with irregular bony trabeculae. It causes bone pain, deformities & pathologic fracture. Fibrous dysplasia is a sporadic benign skeletal disorder that can affect one bone (monostotic) or multiple bone ( polyostotic). Disscusion: The clinical behavior and progression of fibrous dysplasia may also vary, thereby making the management of this condition difficult with few established clinical guidelines. Conclusion: This paper provides a biopsy and reconturing as the choice of treatment.

PERBANDINGAN PROSES PENYEMBUHAN TULANG ANTARA IMPLANTASI HIDROKSIAPATIT NANOKRISTALIN DAN HIDROKSIAPATIT MIKROKRISTALIN (Kajian pada tulang tibia kelinci Andries Pascawinata; Prihartiningsih Prihartiningsih; Bambang Dwirahardjo
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 1, Nomor 1, Juni 2014
Publisher : Universitas Baiturrahmah

Latar belakang. Salah satu bahan alloplastik yang berkembang pesat saat ini yaitu hidroksiapatit (HA) sintetik. Hidroksiapatit sintetik konvensional yang banyak digunakan saat ini yaitu hidroksiapatit mikrokristalin dimana struktrur kristalnya berada dalam kisaran mikrometer. Beberapa dekade terakhir bentuk nanokristalin dari hidroksiapatit (10-100 nm) mendapat perhatian dari banyak peneliti terutama mengenai sifat fisik, mekanik, kimia dan biologisnya karena hidroksiapatit nanokristalin ini lebih menyerupai bentuk hidroksiapatit alami yang terdapat pada tulang dibandingkan hidroksiapatit mikrokristalin. Tujuan dari penelitian ini adalah untuk mengetahui perbandingan proses penyembuhan tulang antara implantasi hidroksiapatit nanokristalin dan hidroksiapatit mikrokristalin. Metode. Jenis penelitian adalah eksperimental dengan hewan coba kelinci berjumlah 18 ekor dibagi dalam 2 kelompok periode dekapitasi yaitu 9 ekor kelinci pada periode dekapitasi 2 minggu dan 9 ekor kelinci pada periode dekapitasi 4 minggu. Masing-masing periode dekapitasi ini kemudian dibagi lagi menjadi 3 kelompok lagi yaitu kelompok implantasi hidroksiapatit nanokristalin, kelompok implantasi hidroksiapatit mikrokristalin dan kelompok kontrol. Data dianalisis menggunakan uji statistik Kruskal wallis dan Mann Whitney U. Hasil. Pertumbuhan tulang baru yang ditunjukkan kelompok HA nanokristalin lebih tinggi dibandingkan HA mikrokristalin secara bermakna pada periode 2 minggu (p = 0,00). Pertumbuhan tulang baru yang ditunjukkan kelompok HA nanokristalin juga lebih tinggi dibandingkan HA mikrokristalin secara bermakna pada periode 4 minggu (p = 0,006). Kesimpulan. proses penyembuhan tulang pada implantasi hidroksiapatit nanokristalin lebih cepat dibandingkan proses penyembuhan tulang pada implantasi hidroksiapatit mikrokristalin.

Effect of pre-operative 40 mg oral methylprednisolone on post- odontectomy facial swelling, intraoral redness, pain and level of TNF-α Harpindo Yusa; Cahya Yustisia Hasan; Bambang Dwirahardjo
Majalah Kedokteran Gigi Indonesia Vol 8, No 1 (2022): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.55116

Odontectomy is the surgical removal of teeth by making a mucoperiosteal flap and reducing the jawbone. This procedure is likely to cause injury and damage to soft and hard tissues, stimulate inflammatory responses, and generate release of proinflammatory cytokines, one of which is TNF- ɑ, resulting in the facial swelling, intraoral redness, and pain. This study was aimed at observing effects of 40 mg methylprednisolone, administered 1 hour before odontectomy on facial swelling, intraoral redness, and pain and level of TNF-ɑ after odontectomy. The randomized placebo-control trial study involved 24 subjects who underwent odontectomy at the Oral Surgery and Maxillofacial clinic of Prof. Soedomo Dental Hospital, Universitas Gadjah Mada. To comply with the inclusion criteria, the subjects were divided into placebo group (12 patients) and methylprednisolone group (12 patients). The observation of facial swelling, intraoral redness, pain (VAS) and level of TNF-ɑ (ELISA) was done before odontectormy, H+1 (24 hours after odontectomy) and H+3 (72 hours after odontectomy). The data gathered were analyzed using Repeated Measures ANOVA and post-hoc Bonferroni (p < 0.05). The results showed that those administered with methylprednisolone an hour before odontectomy experienced less postoperative facial swelling (p = 0.000), a lower score of intraoral redness (p = 0.000), a lower score of pain (p = 0.000) and a lower level of TNF-ɑ (p = 0.000) compared to the placebo. The changes in TNF-α showed the strongest correlation with the changes in postoperative pain and intraoral redness compared with facial swelling. Oral administration of 40 mg methylprednisolone an hour before odontectomy is more effective in reducing facial swelling, intraoral redness, pain and level of TNF-ɑ following odontectomy of mandibular third molar compared with the placebo.

Pengaruh aplikasi wound dressing kepompong ulat sutera (Bombyx mori) terhadap kepadatan kolagen dan kekuatan tarik luka insisi kulit Adyaputra Indrapradana; Cahya Yustisia Hasan; Bambang Dwirahardjo
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 7, No 3 (2021)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.67837

Kepompong ulat sutera (Bombyx mori) merupakan material yang sangat biokompatibel dan memiliki kemampuan regenerasi yang baik terhadap jaringan tubuh manusia dan studi terkini juga menunjukkan bahwa material ini digunakan sebagai wound dressing. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan wound dressing dari kepompong ulat sutera terhadap kepadatan kolagen dan kekuatan tarik luka pada penyembuhan luka insisi kulit. Tikus Wistar jantan sesuai kriteria inklusi sebanyak 28 ekor dibagi secara acak ke dalam 4 kelompok,masing-masing kelompok 7 ekor, berdasarkan waktu dekapitasi dan berdasarkan bahan dressing (dressing kasa sebagai kelompok kontrol dan kepompong ulat sutera sebagai perlakuan). Masing-masing tikus mendapatkan insisi sepanjang 3 cm di kulit punggung tikus dan dijahit 3 simpul simple interrupted dengan benang nylon 4.0. Luka insisi pada punggung tikus ditutup dengan bahan dressing sesuai dengan kelompoknya. Pengamatan kepadatan kolagen dan kekuatan tarik luka dilakukan pada hari pengamatan ke-7 dan ke-14. Uji statistik independent t-test menunjukkan kepadatan kolagen kelompok wound dressing kepompong ulat sutera (bombyx mori) lebih padat dari kelompok kontrol, baik pada pengamatan hari ke-7 (p = 0,000) dan ke-14 (p = 0,000). Kekuatan tarik kelompok wound dressing kepompong ulat sutera (bombyx mori) lebih tinggi dari kelompok kontrol, baik pada pengamatan hari ke-7 (p = 0,000) dan ke-14 (p = 0,000). Penggunaan wound dressing kepompong ulat sutra meningkatkankepadatan kolagen dan kekuatan tarik penyembuhan luka insisi kulit tikus Wistar secara signifikan. Semakin padat kolagen akan meningkatkan kekuatan tarik.

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