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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Biotechnology Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education
Muhammad Mansyur Romi
Department Of Anatomy, Faculty Of Medicine, Public Health And Nursing,Universitas Gadjah Mada, Jalan Farmako, Sekip Utara, Sleman, Yogyakarta 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Inverse correlation of kidney interstitial cells expansion with hemoglobin level and erythropoietin expression in single and repeated kidney ischemic/reperfusion injury in mice Dian Prasetyo Wibisono; Nur Arfian; Muhammad Mansyur Romi; Wiwit Ananda Wahyu Setyaningsih; Dwi Cahyani Ratna Sari
Indonesian Journal of Biotechnology Vol 24, No 1 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (727.855 KB) | DOI: 10.22146/ijbiotech.43989

Abstract

Ischemic/reperfusion injury (IRI) causes acute kidney injury that may lead to chronic kidney disease. We investigated the correlation between kidney interstitial cells expansion, hemoglobin level, and erythropoietin expression as the chronic effects of single and repeated kidney IRI in mice. We created an IRI model using male Swiss mice by clamping the bilateral renal pedicles. Subjects were divided into four groups that contained six mice each: control/sham operation, single acute IRI, single chronic IRI, and repeated IRI. Our results showed that the single chronic and repeated IRI groups significantly increased the tubular injury score, decreased the hemoglobin level, and increased erythropoietin expression compared with the control. Lower hemoglobin levels in all of the groups compared with the control was associated with erythropoietin resistance. In single chronic and repeated kidney IRI, there were decreased creatinine levels compared with the control. The decreased creatinine levels from the single acute IRI group to the single chronic IRI group, suggesting a repair phase of IRI starting on day 7 occurred in the single chronic IRI group. A macrophage marker, CD68, and an inflammatory mediator marker, MCP-1, significantly increased in all IR groups, indicating inflammation occurred due to IRI. In conclusion, chronic and repeated kidney IRI induced interstitial cells expansion and inflammation associated with anemia.
Ethanolic extract of the Centella asiatica (L.) Urb. leaf decreases cerebellar brain-derived neurotrophic factor (BDNF) levels in rats after chronic stress Dwi Cahyani Ratna Sari; Desby Juananda; Mawaddah Ar-Rochmah; Muhammad Mansyur Romi; Nur Arfian
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (770.994 KB) | DOI: 10.19106/JMedSci005002201801

Abstract

Chronic stress produces glucocorticoid-induced neurotoxicity that may lead to alterations of the brain-derived neurotrophic factor (BDNF) concentration in the brain. Cerebellum is known to be severely affected by glucocorticoids-associated oxidative damage. Centella asiatica (L.) Urb. may protect neurons from oxidative damage. This study aimed to investigate the effect of ethanolic extract of C. asiatica (L.) Urb. leaf on the rat cerebellar BDNF levels following stress. Twenty young-adult male Sprague Dawley rats were randomly assigned into four experimental groups. The stress control group received aquadest, and the other groups were treated with different doses of the C. asiatica (L.) Urb. extract i.e 150 (CeA150), 300 (CeA300) and 600 (CeA600) mg/kg body weight/day orally, respectively and followed by chronic footshock stress for 28 days. Upon completion of the experimental period, all animals were sacrificed and the cerebellar was isolated. The BDNF levels from the cerebellar tissue lysate was measured using ELISA. The mean BDNF levels of the cerebellar tissue in the stress control, CeA150, CeA300 and CeA600 groups were 1217.10±301.40; 771.46±241.45; 757.05±268.29; and 627.00±246.02 pg/mL, respectively. Post-hoc analysis showed a significant difference between the control and treatment groups (p< 0.05). In conclusion, the ethanolic extracts of the C. asiatica (L.) Urb. leaf decrease the cerebellar BDNF levels in rats after chronic stress.
IS CADAVER STILL NEEDED IN MEDICAL EDUCATION? Muhammad Mansyur Romi; Nur Arfian; Dwi Cahyani Ratna Sari
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 8, No 3 (2019): November
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.233 KB) | DOI: 10.22146/jpki.46690

Abstract

Background: Medical education has been developing very rapidly. Cadavers, which can serve as very important learning resources, need special concern for their availability and utility.Methods: This narrative review is based on related articles freely downloaded which discuss the role and availability of cadavers worldwide. The recent Indonesian condition with Universitas Gadjah Mada as a case will be described.Results: Cadavers play important roles in several aspects, from bioethics and behavioral development until clinical skills, in basic education and especially in postgraduate and advance clinical training. The availability of cadavers has declined significantly, and as a result, the impacts must be considered. Most cadavers are unidentified bodies, eventhough presently a body donation program is recommended as the alternative source.Conclusion: Currently in Indonesia, timely participation is needed from various stakeholders to support effective and efficient cadaver availability and utility. Additional learning resources are needed to be developed in order to assure quality improvement of medical education.Keywords: cadaver, medical education, bioethics, unidentified bodies, body donation.
Co-Authors Dian Prasetyo Wibisono Dwi Cahyani Ratna Sari Juananda, Desby Mawaddah Ar-Rochmah Nur Arfian Wiwit Ananda Wahyu Setyaningsih