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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Melayu Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Health and Medical Journal

Juananda, Desby

Fakultas Kedokteran Universitas Riau

Author-ID : 806604

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 6 Documents Claim Missing Document

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Articles

Inkontinensia Urin pada Lanjut Usia di Panti Werdha Provinsi Riau Desby Juananda; Dhany Febriantara
Jurnal Kesehatan Melayu Vol 1, No 1 (2017): September 2017
Publisher : Fakultas Kedokteran Universitas Riau

Inkontinensia urin (IU) diartikan sebagai keluarnya urin tanpa disadari yang dapat diamati secara objektif, serta menimbulkan masalah sosial dan kebersihan. IU merupakan salah satu masalah kesehatan yang sering dijumpai pada lanjut usia (lansia). Pada penelitian ini akan dinilai gambaran prevalensi dan dampak IU, serta kualitas tidur pada lansia di Panti Werdha Provinsi Riau. Penelitian ini merupakan penelitian deskriptif dengan rancangan potong lintang yang dilakukan pada 30 orang lansia berusia lebih dari 60 tahun menggunakan instrumen penelitian berupa kuesioner, antara lain Incontinence Impact Questionnaire-7 (IIQ-7), Urogenital Distress Inventory-6 (UDI-6), dan Pittsburgh Sleep Quality Index (PSQI). Pada penelitian ini diketahui bahwa 16 orang (53,33%) lansia mengalami IU, dan umumnya adalah perempuan. Tipe IU yang ditemukan, antara lain tipe urgensi sebanyak 14 orang (87,5%), tipe stres sebanyak 1 orang (6,25%) dan tipe luapan sebanyak 1 orang (6,25%). IU diketahui berdampak pada aktivitas fisik (44,44%), perjalanan (44,44%) dan kesehatan emosional (11,12%). Lansia yang mengalami IU memiliki kualitas tidur yang tidak baik (100%) dan waktu tidur yang singkat (68,75%). Penelitian ini menunjukkan bahwa prevalensi IU pada lansia di Panti Werdha Provinsi Riau cukup tinggi dengan distribusi terbanyak adalah tipe urgensi. IU diyakini sangat berdampak pada aktivitas fisik, emosi dan kualitas tidur.

Ethanolic extract of the Centella asiatica (L.) Urb. leaf decreases cerebellar brain-derived neurotrophic factor (BDNF) levels in rats after chronic stress Dwi Cahyani Ratna Sari; Desby Juananda; Mawaddah Ar-Rochmah; Muhammad Mansyur Romi; Nur Arfian
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Chronic stress produces glucocorticoid-induced neurotoxicity that may lead to alterations of the brain-derived neurotrophic factor (BDNF) concentration in the brain. Cerebellum is known to be severely affected by glucocorticoids-associated oxidative damage. Centella asiatica (L.) Urb. may protect neurons from oxidative damage. This study aimed to investigate the effect of ethanolic extract of C. asiatica (L.) Urb. leaf on the rat cerebellar BDNF levels following stress. Twenty young-adult male Sprague Dawley rats were randomly assigned into four experimental groups. The stress control group received aquadest, and the other groups were treated with different doses of the C. asiatica (L.) Urb. extract i.e 150 (CeA150), 300 (CeA300) and 600 (CeA600) mg/kg body weight/day orally, respectively and followed by chronic footshock stress for 28 days. Upon completion of the experimental period, all animals were sacrificed and the cerebellar was isolated. The BDNF levels from the cerebellar tissue lysate was measured using ELISA. The mean BDNF levels of the cerebellar tissue in the stress control, CeA150, CeA300 and CeA600 groups were 1217.10±301.40; 771.46±241.45; 757.05±268.29; and 627.00±246.02 pg/mL, respectively. Post-hoc analysis showed a significant difference between the control and treatment groups (p< 0.05). In conclusion, the ethanolic extracts of the C. asiatica (L.) Urb. leaf decrease the cerebellar BDNF levels in rats after chronic stress.

The Effect of Immobilization Stress on Gastric Mucosal Histopathology in White Mice (Mus musculus) Male Swiss Webster Strain Rizki Bunaya; Ilhami Romus; Fajri Marindra Siregar; Desby Juananda
Molecular and Cellular Biomedical Sciences Vol 4, No 1 (2020)
Publisher : Cell and BioPharmaceutical Institute

Background: Immobilization stress is one method of stress induction on experimental animals. It affects the psychology and physical of experimental animals and is the recommended method for assessing changes in histological structure damage. The purpose of research was to analyze the effect of immobilization stress on gastric mucosal in mice.Materials and Methods: This research was experimental with post-test-only control group design. Twenty white mice (Mus musculus) male Swiss Webster strains were used in this study and divided into 4 groups: control, immobilization stress 14 days, immobilization stress 21 days, immobilization stress 28 days. Mice were given immobilization stress using 50 cc syringes for 2 hours every day for 14 days, 21 days and 28 days. Gastric mucosal damage in mice was analyzed under a microscope with of 10 fields of view in each sample. Data were analyzed using the Kruskal Wallis test and Mann Whitney test.Results: Gastric mucosal damage score were 0 in control, 1.42±0.265 in 14 days, 1.82±0.265 in 21 days, and 2.54±0.05 in 28 days. There was significant difference between each group (p<0.05), while the greatest damage was found in the 28 days group.Conclusion: These result indicated that immobilization stress caused gastric mucosal damage and the degree of damage is in accordance with duration of stress.Keywords: gastric mucosal, immobilization, stress

Stres Imobilisasi Kronik Mengganggu Memori Spasial Mencit Putih (Mus musculus) Galur Swiss Webster Jantan Desby Juananda; Riezky Valentina Astari
ANATOMICA MEDICAL JOURNAL | AMJ Vol 1, No 1 (2018)
Publisher : Universitas Muhammadiyah Sumatera Utara

Long-term exposure to stress may induce structural and functional alterations in the brain and particularly in hippocampus. Several studies have shown that the hippocampus plays an important role in spatial learning and memory. Certain animals can perceive stressors differently depend on stress durations and paradigms. We have designed an investigation to compare the effect of different chronic stress durations, using immobilization tubes, on mice spatial memory ability. Twenty young-adult (10-12 weeks old; 25-35 g) male Swiss Webster mice were randomly assigned into four groups: control (non-stressed) group and groups were exposed to immobilization stress 2 hours/daily (09.00-11.00 am) for 14, 21 and 28 days, respectively. Spatial memory ability was tested by using Morris Water Maze. Data were analyzed with one-way ANOVA (p<0.05). We found that mean escape latency (s) for control, 2h/14 days, 2h/21 days and 2h/28 days groups were 8.49 ± 0.91, 12.40 ± 3.76, 13.73 ± 4.09, and 41.62 ± 21.84, respectively (p<0.05). Post-hoc analysis showed a statistical difference between control and stressed groups (p<0.05), but there was no statistical difference between 2h/21 days and 2h/14 days group (p>0.05). In conclusion, this study showed that chronic immobilization stress had been proven to impair spatial memory ability in mice. Specifically, our findings support the use of 2h/28 days chronic immobilization paradigm as an efficient method to induce spatial memory deficits in mice. Keywords: immobilization stress, Morris Water Maze, spatial memory

Tes Toleransi Glukosa Oral (TTGO) Pasca Pemberian Suspensi Kedelai Dibanding Suspensi Tempe pada Tikus (Rattus norvegicus Galur Wistar) Diabetik Huriatul Masdar; Muhammad Radhiatul Hakiki; Muhammad Rafi Syahputra; Tommy Satriasumatri; Deskafiani Putri; Rizki Bunaya; Desby Juananda
Health and Medical Journal Vol 3, No 2 (2021): HEME July 2021
Publisher : Universitas Baiturrahmah

Introduction: Genistein, daidzein and glicytein are soybean’s isoflavones which have been known having anti diabetic effect. Fermentation process of soybean can lead to formation aglycan isoflavones which have higher bioavailability than unfermented-soybean. Aims: This research was aimed to evaluate the effect of soybean and tempeh (fermented-soybean) administration to oral glucose tolerance test (OGTT) in diabetic rats. Method: Twenty male Rattus norvegicus Wistar strains were used in this experiment, divided into 4 groups: standard, negative control, soybean and tempeh group. Type 2 diabetes in rats was induced by giving streptozotocin (50 mg/kgBW) and nicotinamide (110 mg/kgBW) intraperitoneally. Blood glucose were measured by using blood glucose test meter and classified into diabetes if its level above 200 mg/dL. Soybean (200 mg/kgBW/day) and tempeh (200 mg/kgBW/day) suspension were given by using gastric tube for 30 days. Results: The results showed the means of either fasting blood glucose (FBG) or 2 hours post prandial blood glucose (2hPP) of negative control were persistent above 200 mg/dL on day 15th and 30th (p> 0,05). In soybean group there was a decrease the mean of FBG on day 15th (p<0.05) but did not reach the normal level, and on day 30th the mean of FBG was <200 mg/dL (p<0.05) however 2hPP blood glucose was still >200 mg/dL (p<0.05). Furthermore, in tempeh group, the means of either FBG or 2hPP blood glucose reached the normal level in day 15th and 30th (p <0.05). Conclusion: the provision of tempeh was better in controlling blood sugar levels than soybean.

Pemeriksaan Metode IVA (Inspeksi Visual Asam Asetat) untuk Pencegahan Kanker Serviks Desby Juanda; Hadrians Kesuma
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 2 No. 2 (2015): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v2i2.25

Kanker leher rahim atau disebut juga kanker serviks adalah sejenis kanker yang 99,7% disebabkan oleh human papilloma virus (HPV) onkogenik, yang menyerang leher rahim. Kelompok berisiko untuk terjadinya kanker serviks adalah wanita di atas usia 30 tahun yang memiliki banyak anak dan dengan perilaku menjaga kesehatan reproduksi yang masih kurang. Kebiasaan gonta ganti pasangan seksual merupakan salah satu faktor utama penularan virus HPv penyebab kanker serviks ini terjadi. Tujuan penelitian ini adalah untuk deteksi kanker serviks pada kelompok beresiko menggunakan pemeriksaan skrining kanker serviks melalui metode IVA (Inspeksi Visual Asam asetat). Ditemukan 1 orang (3%) dari subjek penelitian 30 orang dengan positif IVA pada hasil pemeriksaan serviks inspekulo. Sedangkan 5 orang (16%) mengalami keluhan seperti keputihan dan gatal pada alat kelamin. Pemeriksaan lebih lanjut diperlukan pada pasien dengan IVA Positif untuk memastikan adanya lesi yang mengarah pada keganasan agar penatalaksanaan dapat dilakukan dengan segera.

Co-Authors Deskafiani Putri Dhany Febriantara Dwi Cahyani Ratna Sari Hadrians Kesuma Huriatul Masdar Ilhami Romus Mawaddah Ar-Rochmah Muhammad Mansyur Romi Muhammad Radhiatul Hakiki Muhammad Rafi Syahputra Nur Arfian Riezky Valentina Astari Rizki Bunaya Rizki Bunaya Siregar, Fajri Marindra Tommy Satriasumatri

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