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All Journal WMJ (Warmadewa Medical Journal) Aesculapius Medical Journal
Ni Wayan Armerinayanti
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Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid Ni Wayan Armerinayanti
WMJ (Warmadewa Medical Journal) Vol 1 No 2 (2016): November 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.2.27.42-50

Abstract

Goiter merupakan pembesaran kelenjar tiroid yang dapat berkaitan dengan gangguan primer pada organ tiroid ataupun akibat stimulasi hormonal atau faktor lain terhadap tiroid. Di Indonesia dan di Bali khususnya kasus karsinoma tiroid mengalami peningkatan sejalan dengan peningkatan kasus goiter endemik maupun non endemik. Goiter memiliki faktor risiko sebesar 2,5 kali lipat untuk menimbulkan karsinoma tiroid. Goiter dapat menimbulkan hiperplasia yang bersifat difusa maupun noduler (nodul tunggal dan multipel). Analisis klonal telah membuktikan bahwa hiperplasia merupakan proliferasi yang bersifat poliklonal. Pada tiroid, ditemukan perubahan pola monoklonal pada kelompok nodul yang sebelumnya merupakan nodul hiperplastik. Perubahan poliklonal menjadi monoklonal ini merupakan interaksi antara adanya lesi hiperplastik sebelumnya dengan predisposisi genetik yang selanjutnya menciptakan lingkungan mutagenik, ditandai oleh peningkatan proliferasi sel disertai pembentukan radikal bebas yang memicu adanya mutasi somatiktirosit. Pemberian suplementasi iodium pada kasus goiter endemik, dikatakan berkaitan dengan adanya kandungan iodine radioaktif nantinya justru menimbulkan kerusakan rantai DNA melalui tata ulang RET-TRK.Kata Kunci: goiter, predisposisi, karsinoma tiroid. [Goitre as Predisposing Factor of Thyroid Carcinomas].Goitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders or stimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase of Thyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre increases 2.5 fold risk of thyroid carcinoma. Goitre may cause diffuse and nodular hyperplasia (either single or multiple nodules). Clonal analysis has been discovered that hyperplasia is considered to be polyclonal proliferation. Monoclonal alterations had also been found in a subset of thyroid nodules that were previously considered hyperplastic. Alterations of polyclonal to monoclonal pattern was considered as interaction between past history of hyperplastic lesion and genetic predisposition which furthermore forming mutagenic environment such as increases of cell proliferation and also free radicals induce- somatic mutation. Iodine supplementation on endemic goiter related with radioactive iodine content which damaging DNA sequences in the form of RET-TRK rearrangement.Keywords: goitre, predispose, thyroid carcinoma.
Perbedaan Tingkat Pengetahuan Pencegahan Kanker Serviks SMA Negeri dan Swasta Kelas X Kabupaten Badung : knowledge level on cervical cancer prevention among class X high school female students in public versus the private schools within the Badung Regency. Made Intan Ryani Putri; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
AMJ (Aesculapius Medical Journal) Vol. 2 No. 1 (2022): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.722 KB)

Abstract

The average age for first having sexual intercourse outside of marriage, which is 14-19 years, is one of the causes of the risk of cervical cancer. This research compares the knowledge level on cervical cancer prevention among class X high school female students in public versus the private schools within the Badung Regency. A cross-sectional comparative study is used as the study designed, which includes a total sample of 336 female students (n=336) by utilizing questionnaires. Bivariate analysis with Interdependent T-test and Statistical Package for Social Sciences (SPPS) is appropriate for analyzing the gathered research data. The results of this study between public and private high schools in Badung Regency have different levels of knowledge about cervical cancer prevention. Data analysis shows that 99 (29.5%) female respondents in public high schools know about cervical cancer prevention, and only 80 (23.8%) female students from private schools. The findings of this study imply that school-based teaching is critical for increasing understanding and lowering cervical cancer rates, as well as collaborating with the health department to provide cervical cancer counseling and installing health-related information media in the school environment.
Gambaran Kejadian Diare pada Balita di Rumah Sakit Umum Daerah Wangaya Denpasar Komang Yasmika Utami; Ni Wayan Armerinayanti; Anak Agung Oka Lely
AMJ (Aesculapius Medical Journal) Vol. 3 No. 3 (2023): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Abstract [Overview of the Diarrhea Incidence in Toddlers at the Wangaya Regional General Hospital, Denpasar] Diarrhea is a bowel disease with a frequency of 3 or more times per day which is soft, liquid and can be accompanied by blood, mucus, fat, or undigested food particles. Diarrhea is the main cause of death for children under the age of 5 years in Indonesia, due to malnutrition. The severity of diarrheal disease is determined by nutritional status, duration of diarrhea, degree of dehydration, comorbidities and length of stay in hospital. In the province of Bali, the incidence of diarrhea in children under five years includes 1,275 cases and the highest case finding of diarrhea in children under five years is in the city of Denpasar. This study aims to determine the description of diarrheal disease in children under five years at Wangaya General Hospital Denpasar from January 2020 - July 2021. This study is a descriptive study with a cross sectional design. The research subjects were toddlers aged 12-60 months who were selected based on the purposive sampling method. Collecting data using secondary data from the medical records of the Wangaya Regional General Hospital Denpasar, then analyzed using a univariate test through the SPSS computer program. The results showed that all children under five years with diarrhea in Wangaya General Hospital Denpasar experienced acute diarrhea. The majority of toddlers with diarrhea at the Wangaya General Hospital Denpasar experienced mild or moderate dehydration, received less than 5 days of treatment, experienced symptoms of watery bowel movements, vomiting and fever when they entered the hospital and improved when they were brought home. Keywords : diarrhea, duration of diarrhea, degree of dehydration, length of stay in hospital
Hubungan Stres dengan Motivasi Belajar pada Siswa SMA Negeri 1 Ubud Kadek Berliantara; Putu Asih Primatanti; Ni Wayan Armerinayanti
Aesculapius Medical Journal Vol 4 No 2 (2024): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.4.2.2024.189 - 193

Abstract

[The Relationship between Stress and Learning Motivation in Ubud 1 Public High School Students] Stress refers to mental and emotional disturbances that can arise from both internal and external factors. Learning motivation is a desire that oroginates within the student and lead to various learning activities. Due to the lack of previous research on this topic at SMA Negeri 1 Ubud, it is crucial to conduct this study in order to gather relevant , which could potentially benefit the school. This research can help the school prevent the factors that cause stress in students and increase the learning motivation. this study used descriptive analytic with a cross-sectional approach. This research was conducted at SMA Negeri 1 Data was collected using Perceived Stress Scale questionnaire (PSS-10) and Motivated Strategies for Learning Questionnaire (MSLQ-18). Furthermore, data analyzed both univariately and bivariately using the SPSS 25th version and Spearman test method, considering the analysis significant if the p value is less than 0.05. The univariate analysis revealed that the majority of students were 16 years old (36.2%), with a majority of female students (55.7%) and a majority of class XI students (33.8%). The Spearman correlation test's bivariate analysis yielded a significance value of 0.000, with a significant level of 0.05. The correlation coefficient, which stands at 0.241, indicates a weak relationship. The negative correlation coefficient number indicates an opposite relationship between the two variables, suggesting that higher stress levels lead to decreased learning motivation among SMA Negeri 1 Ubud students.
Co-Authors Anak Agung Oka Lely Kadek Berliantara Komang Yasmika Utami Made Intan Ryani Putri Ni Luh Putu Eka Kartika Sari Putu Asih Primatanti