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All Journal Jurnal Medika Veterinaria
Firdausy Kurnia Maulana
Faculty of Veterinary Medicine, University of Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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9. The Effect Of L-Arginine On Decreasing Foam Cell Development Post Surgical Embolectomy With Fogarty Balloon Catheter On Iliac Arteries Of Rabbit Firdausy Kurnia Maulana; Romziah Sidik; Ngakan Made Rai Widjaja
Jurnal Medika Veterinaria Vol 15, No 1 (2021): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v15i1.12277

Abstract

Vascular injury caused by Fogarty balloon cathetering lead on endothelial dysfunction and trigger the development of foam cell, early atherosclerosis plaque. L-Arginine, as a nitric oxide precursor, has shown to decrease foam cell development. The aim of this study is to prove the effect of L-Arginine on decreasing the amount of foam cell post surgical embolectomy with Fogarty balloon catheter on iliac arteries of rabbit. Sixteen male rabbits were randomized divided into two group of treatment (n=8). After surgical embolectomy in right iliac artery has done, rabbits were fed standard ration (T0) and standard ration with oral L-Arginine (T1). At 28 days after surgical embolectomy, necropsy was done and foam cells were counted. Vascular injury by Fogarty balloon catheter resulted in the development of foam cells both in T0 (13.38 ±14.64) and T1(1.49 ± 1.20). Unpaired t test result showed not significant different (p0.05). The conclusion of this research is L-Arginine reduces the amount of foam cell post surgical embolectomy with Fogarty balloon catheter on iliac arteries of rabbit, however statistical test did not show any difference.
Co-Authors Ngakan Made Rai Widjaja Romziah Sidik