Dewi Kania Intan Permatasari
Universitas Padjadjaran

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THE ROLE OF VITAMIN D SUPPLEMENTATION FOR HEAD AND NECK CANCER : A LITERATURE REVIEW Dewi Kania Intan Permatasari; Irna Sufiawati
ODONTO : Dental Journal Vol 6: Special Issue 1. April 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.1.59-65

Abstract

Background: Vitamin D has several roles, namely physiological function of calcium and bone metabolism, cell growth and differentiation, immune and cardiovascular function. Vitamin D deficiency can cause the risk of cancer. Head and neck cancer is one of the cancers that occur due to vitamin D deficiency in the body. This literature review was to asses and evaluate the impact and benefits of vitamin D supplementation for head and neck cancer.Discussion: A study found an association between vitamin D supplementation and a low risk of recurrence in conditions of high total vitamin D levels. Another study found a significant increase in quality of life (QOL). The primary mechanism of vitamin D action is mediated through binding of either 1,25(OH)2D3 (active form) or 25(OH)D (less active form) to the VDR, which is a member of the nuclear receptor superfamily of steroid and thyroid hormones with gene-regulatory and consequent anti-proliferative properties.Conclusions: Vitamin D supplementation provides a role in improving the condition of patients with head and neck cancer. Both in terms of suppressing recurrence and in terms of increasing quality of life
Perawatan rekurensi HSV-1 dan eritema multiforme yang dipicu oleh kapsaisin yang terkandung dalam cabai rawit (Capsicum frutescens)Treatment of HSV-1 recurrence and erythema multiforme triggered by capsaicin of tabasco pepper (Capsicum frutescens) Dewi Kania Intan Permatasari; Riani Setiadhi
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 3 (2019): Desember 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v31i3.23843

Abstract

Pendahuluan: Eritema multiforme (EM) adalah suatu kondisi mukokutaneus akut sebagai akibat reaksi hipersensitifitas dengan berbagai etiologi, salah satu pencetusnya disebabkan oleh zat adiktif pada cabai rawit (Capsicum frutescens). Cabai rawit memiliki zat aktif yang dinamakan kapsaisin. Rangsangan kapsaisin pada neuron yang terinfeksi herpes simplex virus-1 laten menyebabkan reaktivasi. Kapsaisin sebagai zat pemberi rasa pada makanan harus menjadi perhatian karena panas yang ditimbulkan dapat menyebabkan terjadinya eritema multiforme. Tujuan dari pembuatan laporan kasus ini adalah melaporkan hasil perawatan rekurensi HSV-1 dan eritema multiforme yang dipicu oleh kapsaisin yang terkandung dalam cabai rawit. Laporan kasus: Seorang wanita berusia 50 tahun, datang ke instalasi Ilmu Penyakit Mulut Rumah Sakit Gigi dan Mulut Universitas Padjadjaran (RSGM Unpad) dengan keluhan terdapat luka di bibir kiri bawah sejak 1 bulan sebelumnya dan belum sembuh. Luka pada bibir ini terjadi untuk yang kedua kalinya. Pasien memiliki kebiasaan mengkonsumsi cabai rawit berlebihan dalam makanannya. Pemeriksaan ekstra oral mendapatkan lesi pada bibir bawah kiri berupa krusta sanguinolenta dengan tendensi perdarahan, bibir atas dan bawah kering serta eksfoliatif. Pemeriksaan intra oral tidak menemukan lesi di rongga mulut. Hasil pemeriksaan laboratorium menunjukkan peningkatan nilai anti HSV-1 IgG dan IgE. Terapi non farmakologis yang diberikan yaitu oral hygiene instructions dan menghindari makanan pedas/cabai rawit; serta terapi farmakologis berupa kompres NaCl 0,9%, asiklovir oral dan krim hidrokortison 1%. Kunjungan ke-3 lesi pada bibir pasien sudah sembuh. Simpulan: Terapi non farmakologis berupa oral hygiene instructions dan menghindari makanan pedas/cabai rawit serta terapi farmakologis berupa kompres NaCl 0,9%, asiklovir  oral dan krim hidrokortison 1% dapat menyembuhkan pasien dengan rekurensi HSV-1 dan eritema multiforme yang dipicu oleh kapsaisin yang terkandung dalam cabai rawit.Kata kunci: Cabai rawit, kapsaisin, HSV-1, eritema multiforme. ABSTRACT            Introduction: Erythema multiforme (EM) is an acute mucocutaneous condition as a result of hypersensitivity reactions with various etiologies, one of which is caused by an addictive substance on tabasco pepper (Capsicum frutescens). Tabasco pepper has an active substance called capsaicin. Stimulation of capsaicin in neurons infected with latent herpes simplex virus-1 causes reactivation. Capsaicin as a food-flavouring agent must be a concern because the heat generated can cause erythema multiforme. The purpose of this case report was to report the results of the treatment of HSV-1 recurrence and erythema multiforme triggered by capsaicin of tabasco pepper. Case report: A 50-year-old woman came to the Oral Medicine Installation of Universitas Padjadjaran Dental Hospital (RSGM Unpad) with a complaining a wound on the lower left lip since the previous month and had not healed since. This lip injury occurred the second time. Patients have a habit of consuming excessive tabasco pepper in every meal. An extraoral examination found lesions on the left lower lip in the form of sanguinolent crust with a tendency to bleed, upper and lower lip dry and exfoliative. An intraoral examination found no lesions in the oral cavity. Laboratory tests showed an increase in anti-HSV-1 IgG and IgE values. Non-pharmacological therapies given were oral hygiene instructions and avoiding spicy foods/tabasco pepper, and pharmacological treatment in the form of 0.9% NaCl compress, oral acyclovir, and 1% hydrocortisone cream. In the 3rd visit, the lesion on the patient's lips has healed. Conclusion: Non-pharmacological therapy in the form of oral hygiene instructions and avoiding spicy foods/tabasco pepper as well as pharmacological treatment in the form of 0.9% NaCl compress, oral acyclovir, and 1% hydrocortisone cream able to cure patients with HSV-1 recurrence and erythema multiforme triggered by capsaicin of tabasco pepper.Keywords: Tabasco pepper, capsaicin, HSV-1, erythema multiforme.
THE ROLE OF VITAMIN D SUPPLEMENTATION FOR HEAD AND NECK CANCER : A LITERATURE REVIEW Dewi Kania Intan Permatasari; Irna Sufiawati
Odonto : Dental Journal Vol 6: Special Issue 1. April 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (760.459 KB) | DOI: 10.30659/odj.6.1.59-65

Abstract

Background: Vitamin D has several roles, namely physiological function of calcium and bone metabolism, cell growth and differentiation, immune and cardiovascular function. Vitamin D deficiency can cause the risk of cancer. Head and neck cancer is one of the cancers that occur due to vitamin D deficiency in the body. This literature review was to asses and evaluate the impact and benefits of vitamin D supplementation for head and neck cancer.Discussion: A study found an association between vitamin D supplementation and a low risk of recurrence in conditions of high total vitamin D levels. Another study found a significant increase in quality of life (QOL). The primary mechanism of vitamin D action is mediated through binding of either 1,25(OH)2D3 (active form) or 25(OH)D (less active form) to the VDR, which is a member of the nuclear receptor superfamily of steroid and thyroid hormones with gene-regulatory and consequent anti-proliferative properties.Conclusions: Vitamin D supplementation provides a role in improving the condition of patients with head and neck cancer. Both in terms of suppressing recurrence and in terms of increasing quality of life