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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Plastik Rekonstruksi Jurnal Rekonstruksi dan Estetik Academic Hospital Journal

Ishandono Dachlan

Plastic And Reconstructive Surgery, Department Of Surgery, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Universitas Gadjah Mada /Dr. Sardjito General Hospital, Yogyakarta

Author-ID : 289028

Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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A comparison study on the blood transfusion reaction between the elective and the emergency operation’s patients Hidayati Samsiarah Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.226 KB)

Blood transfusion is principally a process of transferring blood or blood components from one individual (the donor) toanother individual (the recipient). Blood transfusion can be either a life saving condition or a life threatening situation dueto the complications happened. Therefore, blood transfusion should be conducted with clear and accurate indication inorder to obtain a condition in which the advantages outweighs the disadvantages. The aim of this study was to evaluatethe differences of the blood transfusion reactions between the patients underwent the emergency surgery with theelective surgery. This was a cross sectional study using data from the medical records from January to December 2009and from the observation on blood transfusion patients from January to May 2010. Data were analyzed using independentt-test, Chi-square test or the logistic regression, with 95% confidence interval (p<0.05). Two hundred and sixty eightdata from medical records and directly observation on blood transfusion patients were obtained during the study. Thewere significant differences of patient reactions after blood transfusion on both types of operation and blood componentstransferred (p<0.05).The transfusion reactions were more frequent in emergency surgery (54.9%) compared withelective surgery (30.5%). Based on types of blood component transfered, the transfusion reaction was more frequentafter Whole Blood/WB transfusion (84.9%) compared with Packed Red Cell/PRC transfusion (25.1%) and Fresh FrozenPlasma/FFP transfusion (25%). The types of operation and blood products had been proven to be the risk factors in bloodtransfusion. Moreover the blood products contributed more in the transfusion reactions compared with the types ofoperation (p<0.05). Amount of transfused blood based on haemoglobin correction formula on both the emergency orelective operations was not significantly different (p>0.05). In conclusion, blood transfusion reactions happened morefrequently in emergency surgery than elective surgery. The WB also generated transfusion reaction more frequently thanthe PRC. The amount of blood required based on hemoglobin correction formula for most patients was similar to the bloodtransfused.Key words: blood transfusion-type of operation-transfusion reaction - whole blood-haemoboglobin correction formula

The influence of non-selective and selective-COX-2 NSAIDs post-minor surgery for the turning of the bleeding time. Ishandono Dachlan Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: NSAIDs remain among the most widely prescribed drugs worldwide, including for surgical cases. Their action are primarily by inhibiting cyclo-oxigenase (COX), the key enzyme catalyzing the biosynthesis of prostaglandins (PGs). There are two similar but distinct isoforms of the enzyme - COX-1 and COX-2. One of the effects of COX-1 inhibition (nonselective NSAIDs) is decreasing thromboxanes, which is one of the important factors in thrombocytes aggregation and blood clotting. The optimal thrombocyte aggregation is required in many surgical cases, especially in microsurgery.Objective: The aim of this study is to compare the influence of non-selective and selective-COX-2 NSAIDs in the turning of the bleeding time.Methods: A prospective study of five days using NSAIDs has been done. The subjects were randomly distributed into two groups, non-selective group and selective COX-2 inhibitor group. The bleeding time was measured prior and after five days using of NSAIDs. The result was analyzed with t-test. Results: The mean of the prior bleeding time was 2.85 minutes (non-selective group) and 2.90 minutes (selective-COX-2 Inhibitor group). After five days using of NSAIDs, the bleeding time was increased from 2.85 to 3.15 minutes (non-selective group) and 2.90 to 2.95 minutes (selective COX-2 Inhibitor group). The mean of the bleeding time difference were 0.3 minutes (non-selective group) and 0.05 minutes (selective COX-2 Inhibitor group). T-test analysis showed that bleeding time was increased significantly from 2,85 minutes up to 3.15 minutes (p=0.005) after five days using non-selective NSAIDs, while there was no significant increase of bleeding time, from 2.90 minutes up to 2.95 minutes (p=0.591) after five days using of selective COX-2 inhibitor NSAIDs.Conclusion: Selective COX-2 inhibitor NSAIDs did not increase the bleeding time, while non-selective NSAIDs increased bleeding time after five days usage.Keyword: NSAIDs - selective - COX2 inhibitor - bleeding time - thromboxanes

The occurence of complication in post punctured vasectomy vs standard method Ishandono Dachlan Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 04 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Punctured Technique of Vasectomy is a simple and refined method of vasectomy. This method was introduced to make fewer complications and to remove the fear of surgical knife.Objective: This study was aimed to assess the ease of procedure, safety, and effectiveness of Punctured Technique of Vasectomy.Methods: A prospective study of 80 acceptors has been done at Dr. Sardjito Hospital Yogyakarta from January 1991 up to Jury 1991. These subjects were randomly distributed into two groups, Punctured Method (39) and Standard Method (41). Duration of operation and complication done during operation was recorded. The follow up for complication was recorded in the second week post-operative, and sperm analyses was done in the tenth week post-operative.Results: Duration of Punctured Method (9,7179 Â± 2,9731 minutes) was significantly different (p-value =0,0006) compared to that of Standard Method (12,1951 Â± 3,2421 minutes). There were two complications during Punctured Method operation compared to six complications during Standard Method operation (RR =1,54; 95%Cl: 0,97 - 2,46). In the second post-operative week, there was no complication in the Punctured Method group, while there was one wound infection in the Standard Method group. Sperm analysis both groups showed no active spermatozoon.Conclusion: Punctured Method is easier than Standard Method, and there was no difference of effectiveness in both methods.Key words: punctured vasectomy - complications - sperm - analysis

The diagnostic value of fine needle aspiration biopsy and ultrasonography on thyroid nodule in Dr. Sardjito General Hospital, Yogyakarta Wicaksono Probowoso Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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As the prevalence of thyroid cancer increases, a diagnostic method that can identify malignancy that warrants further surgical treatment is needed. Fine needle aspiration biopsy (FNAB) and ultrasonography (USG) are preoperative test for diagnosing thyroid tumor. This research aimed to calculate the diagnostic value of FNAB and USG on thyroid nodule patients in Dr. Sardjito General Hospital, Yogyakarta. This was a diagnostic test study using a retrospective designusing data from medical records of patients with thyroid nodules from January 2006 to December 2010. The diagnositic value of FNAB and USG including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated and compared with histopathological examination as the gold standard. Ninety medical records data of patients consisting of 71 females and 19 males who were diagnosed thyroid nodule with FNAB or USG before surgery were evaluated in this study. The results of FNAB of 90 patients were as follows: 54 (60.0%) benign, 6 (6.7%) malignant, and 30 (33.3%) follicular neoplasm. Meanwhile, the results USG of 90 patients were as follows: 38 (42.2%) benign, 15 (16.7%) malignant and 37 (41.1%) non determined. The diagnostic value of FNAB was described as follows: sensitivity of50.0%, specificity of 100%, PPV of 100%, NPV of 50.0% and an accuracy of 60.0%, whereas the diagnostic value of USG was described as follows: sensitivity of 81.8%, specificity of87.5%, PPV 60%, NPV 94.5% and accuracy of 50.0%. In conclusion, the diagnostic value of FNAB and USG in stablishing diagnosis of thyroid nodule is still low. The FNAB has higher accuracy compared to USG for diagnosing thyroid nodules.Keywords: diagnostic value - fine needle aspiration - ultrasonography - thyroid nodule - histopathological examination

Penile granuloma caused by liquid silicone injection Ishandono Dachlan Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Various alloplastic injectable implants have been developed for soft tissue augmentation withoutsurgery. Silicone is a polymer from a family of chemically related organo-silicone compounds that mayexist in any state from a fluid to a solid. Injectable liquid silicone has been used for various cosmetictreatments, mainly for soft tissue augmentation, for example lip, cheek, breast, buttock, and penile. Liquidsilicone has been implicated in variety of adverse inflammatory reactions, sometimes resulting in tissuedestruction.We describe an adverse granulomatous reaction after the injection of liquid silicone for penile augmentation.Penile granuloma can occur as an adverse effect of penile enlargement with the injection of high viscositysolution, like silicone (siliconoma), paraffin (paraffinoma), vaseline or mineral oil. Penile granuloma is arare case which needs an accurate management.We found 30-years old man that occurs 5 weeks after non medical injection of liquid silicone. Surgicalmanagement was done with an excision of the granuloma and round incision on the upper penile, exceptthe urethral part. There were no complications following the treatment. Histopathology examination showedthe appearance of silicone-like foreign body granuloma and fibrosis of the preputium. It is concluded that Injection liquid silicone for penile augmentation could cause adverse granulomatous. Surgical management can be done with an excision of the granuloma.Keywords: liquid silicone, penile granuloma, surgical excision.

Prognostic factors affecting the mortality of 2nd and 3rd degree burn injuries at a tertiary care center in Indonesia Ishandono Dachlan; Khoirul Anam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

About two million people suffer from burn injuries in the United States eachyear, with 100,000 hospitalized in the burn unit. Around 1000 patients sufferfrom severe burn injuries, with each year average of 300 deaths. Improvementsin the understanding of the prognostic factors affecting burn injuries over thepast decades have led to advances in medical and surgical treatment. However,comprehensive data on the factors affecting burn injuries in Indonesia havenot been available, yet. The aim of the study was to investigate the prognosticfactors affecting the mortality of 2nd and 3rd burn injuries patients in Dr. SardjitoGeneral Hospital, Yogyakarta. This was a cross-sectional study conducted withinthe period of 2007-2011 using secondary data from the Department of MedicalRecords. Chi-square and logistic regression analysis were used to evaluate thecorrelation between the prognostic factors and the mortality. A p value < 0.05(95% confidence interval) was considered to be significant. A significantlycorrelation between age, burn injuries percentage, arrival time, inhalation trauma,hemoglobin level, albumin level, creatinine level, hematocrit level and the patient’smortality was observed in this study (p<0.05). However, the cause of burn injuriesand leukocyte count had no correlation with the patient’s mortality (p>0.05).Furthermore, patients with albumin level < 3.5 mg/dL, burn injuries percentage>50%, inhalation trauma and hospitalized in 24 hours after the incident were at22.98, 7.65, 3.0 and 4.59 times higher risk of mortality, respectively (p<0.05).In conclusion, albumin level, burn injury percentage, inhalation trauma and time ofarrival are prognostic factors affecting the mortality of the burn injuries patients.

The effect of mitomycin-c in keloid fibroblast cultures Ishandono Dachlan; Teguh Aryandono; Mae Sri Hartati Wahyuningsih; Hardyanto Soebono; Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 3 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACTKeloid occurs due to hyperactivity of keloid fibroblast (KF) in proliferation, migration, collagen deposition, together with low rates of collagen degradation. These are under the responsibility of TGF-b. Mitomycin C (MC) is used for treating keloid by a topical application during surgery at the level of 0.02% to 0.08%. Unfortunately, the lowest effective level of MC for keloid has not been determined yet. We aimed to determine the lowest effective level of MC in the suppression of KF activities. Various levels of MC diluted in growth medium were administered on KF that were isolated from six patients. After 24 hours and 72 hours of incubation, cellular proliferation, collagen deposition, cellular migration and level of TGF-b, were analyzed. Application of 120 uM MC on KF culture for 24 hours could significantly reduce TGF-b production from 1265.74 ± 274.81 pg/mL to 265.17 ± 12.20 pg/mL; proliferation index from 100% to 84.01 ± 12.91%; inhibit cellular migration to 64.38 ± 3.66%; but reduce collagen depositions from 100% to only 91.13 ± 10.19%. The lowest MC level is on 30 uM or equal with 0.001%. In conclusion, the lowest level of MC can suppress the activities of KF is 0.001%. Moreover, due to low activity in inhibiting collagen deposition, MC would be better as an adjuvant drug for keloid surgery.

The effect of human saliva compared to Aloe vera on wound healing of 2nd degree burn injury in animal models Budi Cahyono Putro; Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Burn injury is one of the common causes of injury that has relatively high morbidity and mortality. Several studies using herbal and traditional medicine from different countries have been documented in burn injury management. Human saliva that contains antibacterial, antifungal, antiviral and analgesic components as well as growth factors can induce re-epithelialization process in 2nd degree burn injury. Whereas, Aloe vera that influence a physiological moist condition was proven can induce re-epithelialization process lead to faster wound healing. This study aimed to compare topical application of human saliva and A. vera on wound healing process of 2nd degree burn injury. This was an experimental study using post-test only control group design using 27 white rats (Rattus novergicus) of Sprague Dawley strain divided into 3 groups with 9 rats in each group. Group I were applied 1 mL of human saliva, Group II were applied A. vera and Group III as control were applied NaCl. Change in body weight and macroscopic clinical assessment were observed every day for 14 days, whereas histological examination was observed on day 14. The data were presented as mean ± standard error of the mean (SEM) and analyzed using one-way analysis of variance (Anova). The result showed that the wound healing process at each treatment showed different level. The human saliva application tended to show faster wound healing process of 2nd degree burn injury compare with A. vera or NaCl (p

Sepsis risk factor in mount Merapi eruption victims with 2nd or 3rd degree of burn injury Yamoguna Zega; Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Sepsis is one of the fatal complications of burns. It is the most common cause of deathfrom burns. Burn sepsis usually occurs after a burn injury develops into infection. Thisstudy was conducted to determine correlation between age, burn area, inhalation trauma,enteral nutrition start time, escarotomy time, and albumin level of sepsis in patientswith 2nd or 3rd degree burn injury. This was a cross sectional study during May to June2012. The subjects in this study were 39 victims of mount Merapi eruption in 2010 whosuffered 2nd or 3rd degree of burns injury. The result showed the correlation betweenwidespread burns, inhalation trauma, time of escarotomy, and albumin levels with sepsis(p < 0.05). In conclusion, the risk factor for sepsis in patients with 2nd or 3rd degree ofburns injury are the area of burns (> 50%), inhalation trauma, time of escarotomy (> 72hours), and albumin levels (<3.5g/dL).

Co-Authors - Sagiran Adeodatus Yuda Handaya Budi Cahyono Putro Dewajani Dewajani Hardyanto Soebono Khoirul Anam Mae Sri Hartati Wahyuningsih Mahandaru, Danu Prawoto, Almas Nur R. Wahyu Kartiko Tomo Sukasah, Chaula Luthfia Teguh Aryandono Wahdini, Siti Isya Wicaksana, Aditya Yamoguna Zega Yohanes Widodo Wirohadidjojo

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