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All Journal Jurnal Ilmu dan Teknologi Kelautan Tropis Jurnal Farmagazine
Sophi Damayanti
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Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology

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THE CONTENT OF FATTY ACIDS IN INDONESIA’S FISH OIL Indra T Maulana; Sukraso Sukraso; Sophi Damayanti
Jurnal Ilmu dan Teknologi Kelautan Tropis Vol. 6 No. 1 (2014): Electronik Jurnal Ilmu dan Teknologi Kelautan Tropis
Publisher : Department of Marine Science and Technology, Faculty of Fisheries and Marine Science, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.394 KB) | DOI: 10.29244/jitkt.v6i1.8635

Abstract

Study of fatty acid content was conducted in six Indonesian fish oils taken from Surabaya, Sorong, Garut, Banyuwangi, and  fish oil standard. The acid and peroxide values were a main parameters which affecting the quality of the fish oil. These parameters were set using the method stated on the SNI No. 01-3555-1998. The oil containing omega-3 such as EPA and DHA is beneficial for health. The study of fatty acid content in six fish oils were analyzed by GCMS Shimadzu QP 2010 ULTRA with FID Detector. RTX-5 were used as a column (diphenyl dimethyl polysiloxane  as a solid buffer, size length 30 m, diameter 0,25 mm, and He as a gas mobile phase).  The results showed that acid values for oil 1, 2, 3, 4, 5, and 6 were 0.55%, 0.50%, 0.48%, 0.55%, 0.48%, and 0.58%, respectively. While the peroxide values were 5.67, 4.72, 4.45,5.01, 4.85, and 5.27 meq/kg, respectively. GCMS analysis showed that fish oil 1, 2, 3, and 4  very dominant containing squalene of  29.45%, 32.34%, 21.07%, and 43.49%, respectively. While oil 6 contained EPA of 8.97% and DHA 6.56%, and that was the highest compared with other oils. However, oil 6 also contained a trans fatty acids i.e., elaidic acid of 26.8% and trans-13-docosanoic acid of 0.9%. For comparison, natural oil 5 was rich of linoleic acid  (39.58%).  The GCMS's analysis results proved that the oil 6 made from lemuru had a big potency to be developed for an Indonesian fish oil export comodity. Keywords: fish oil, EPA, DHA, squalena, GCMS, acid value, peroxide value
PREDIKSI TOKSISITAS SENYAWA ANTIOKSIDAN ALAMI DAN ANALISIS INTERAKSINYA TERHADAP RESEPTOR VEGF-1 MENGGUNAKAN METODE MOLECULAR DOCKING Dina Pratiwi S.Si, M.Si; Muhammad Insanu; Sophi Damayanti
Jurnal Farmagazine Vol 1, No 1 (2014): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v1i1.40

Abstract

Antioksidan merupakan zat yang mampu melindungi pangan dari proses oksidasi. Penggunaan antioksidan sintetik telah menjadi perdebatan dikarenakan efek negatif yang ditimbulkannya. Antioksidan alami dari tumbuhan dapat menjadi senyawa potensial sebagai bahan tambahan pangan alternatif. Namun belum banyak penelitian mengenai efek toksik antioksidan alami. Penelitian ini dilakukan untuk memperoleh prediksi toksisitas 300 senyawa antioksidan alami tumbuhan menggunakan metode in silico dan analisis interaksinya dengan reseptor VEGF-1 melalui metode molecular docking. Prediksi toksisitas senyawa dilakukan menggunakan perangkat lunak T.E.S.T, Toxtree, ADMET predictor, dan QSAR Toolbox. Analisis senyawa uji dengan reseptor VEGF-1 melalui molecular docking dilakukan menggunakan perangkat lunak Autodock 4.2.6. Hasil analisis molecular docking terlihat bahwa terdapat interaksi antara senyawa uji dengan reseptor melalui adanya kemiripan residu asam amino yang berdekatan seperti pada senyawa pembanding dan adanya ikatan hidrogen. Interaksi dengan reseptor VEGF-1 pada uji karsinogenitas menunjukkan asam rosmarinat dan kapsaisin memiliki energi bebas ikatan terendah dengan nilai -8,54 dan -8,11 kcal/mol. Kata kunci: antioksidan alami, molecular docking, VEGFR-1
Co-Authors Dina Pratiwi S.Si, M.Si Indra T Maulana Muhammad Insanu Saeful Amin Slamet Ibrahim Sukraso Sukraso