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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) Jurnal Penelitian Saintek Jurnal Pendidikan Kimia (JPKim) Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Indonesian Journal of Chemistry and Environment

Suwardi Suwardi

Jurusan Pendidikan Kimia FMIPA Universitas Negeri Yogyakarta

Author-ID : 2905974

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Education Environmental Science Materials Science & Nanotechnology Mathematics

Published : 8 Documents Claim Missing Document

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Articles

SYNTHESIS DIBENZIL IS REGISTERED THROUGH THE POLYMERIZED POLYMERYLENE AS ALTERNATIVE RECYCLE PLASTIC RECYCLE Suwardi Suwardi; Crys Fajar Partana; Agus Salim
Jurnal Penelitian Saintek Vol 10, No 1: April 2005
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Synthesis dibenzyl terephathalate were done through PET softdrinkbottles degradation by refluxing in benzyl alcohol at 14~C temperature for 20, 24. and 28 hours in the presence of zinc acetate catalyst. The result of degradation was purified by recristalization in methanol and then melting point (mp), FTIR, I H NMR spectra, and TLC spot were determined. The melting point of product degradation.for 28 hours was 98-99 "c. Based FTIR spectra known thatcompounds of product degradation have OH, C=O, C-O, CH,monosubstituted benzene, disubstituted benzene groups, while on IH NMR spectra showed chemical shift at 8.2 ppm (s, IO H of monosubtituted benzene), 7.5 ppm (s, 9 H consist of 4 H disubstituted benzene and 5 H of aromatic benzyl alcohol), 5.4 ppm (s, 1 H from OH benzyl alcohol), 4.8 ppm (s, 4 H of methylene), and 2.9 ppm (s. 7H of other traces). The single spot ofTLC plate indicated that productdegradation for 28 hours might be a single compound. Based these characterization concluded that compound of product degradation was dibenzyl terephthalate contains benzyl alcohol and other traces.

Pengembangan Metode Pembelajaran Kooperatif secara Online pada Kuliah Kimia Fisika II Marfuatun Marfuatun; Endang Widjajanti LFX; Suwardi Suwardi
Jurnal Pendidikan Matematika dan Sains Vol 1, No 2 (2013): December 2013
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta

Tujuan penelitian ini adalah untuk mengetahui desain, tingkat keterlaksanaan dan efektivitas pembe-lajaran kooperatif secara online pada kuliah Kimia Fisika II. Penelitian ini didesain sebagai penelitian pengembangan dengan tujuh tahap yaitu perencanaan, pengembangan metode, aplikasi I, revisi I, aplikasi II, revisi II dan evaluasi. Hasil penelitian menunjukkan bahwa desain metode pembelajaran kooperatif seca-ra online yang lebih efektif adalah pembagian kelompok, kuliah tatap muka dengan dosen, diskusi dilaku-kan secara online, penulisan laporan kegiatan diskusi secara online, dan evaluasi secara online. Tingkat keterlaksanaan penerapan metode pembelajaran kooperatif secara online cukup baik, namun perlu adanya dukungan sarana yang memadai, baik komputer maupun server e-learning. Adapun penerapan metode pembelajaran kooperatif secara online dianggap belum efektif, karena tingkat ketuntasan belajar mahasiswa baru mencapai 25,93% dengan nilai rata-rata 65,7.Kata kunci: pembelajaran kooperatif, online, efektivitas

Hydration Structures and Dynamics of Ga3+ Ion Based on Molecular Mechanics Molecular Dynamics Simulation (Classical DM) Muhammad Syaekhul Anam; S. Suwardi
Indonesian Journal of Chemistry and Environment Vol 4, No 2 (2021): DECEMBER 2021
Publisher : Universitas Negeri Yogyakarta

The structure and hydration dynamics of Ga3+ ion have been studied using classical Molecular Dynamics (MD) simulations. The data collection procedure includes determining the best base set, constructing 2-body and 3-body potential equations, classical molecular dynamics simulations based on 2-body potentials, classical molecular dynamics simulations based on 2-body + 3 potential-body. The trajectory file data analysis was done to obtain structural properties parameters such as RDF, CND, ADF, and dynamic properties, namely the movement of H2O ligands between hydrations shells. The results of the research indicated that the hydration complex structure of Ga(H2O)83+ and Ga(H2O)63+ was observed in molecular dynamics simulations (MM-2 body) and (MM-2 body + 3-body), respectively. The movement of H2O ligands occurs between the first and second shell or vice versa in the MD simulation of MM-2 bodies but does not occur in MD simulations of (MM-2 bodies + MM-3 bodies). Therefore, the water ligands in the first hydrated shell are stable.

Hydration Structures and Dynamics of In3+ Ion based on Classical Molecular Dynamics Simulation Novan A. A. Permana; Suwardi Suwardi
Indonesian Journal of Chemistry and Environment Vol 4, No 1 (2021): JUNE 2021
Publisher : Universitas Negeri Yogyakarta

The hydration structures and dynamics of In3+ ion have been studied using classical Molecular Dinamics (MD) simulation. The best basis sets were optimized to construct the 2-bodies, 3-bodies correction equations, and analysis of the trajectory file of the simulation results in the form of the parameter of a solvation structure such as RDF, CND, ADF, and dynamic properties, namely the migration of water ligands between the hydration shells. The results showed that the hydration structure of the In3+ ion is In(H2O)93+ and In(H2O)63+, respectively. The geometric arrangement of In3+ hydration obtained through the simulation of classical Molecular Dynamics 2-bd MM 2-bd corrected 3-bd effect is octahedral, which agrees with experimental data and shows the importance of 3-bd correction. The exchange of H2O ligands between the first and second shell or vice versa was not observed during the classical Molecular Dynamics simulation process (2-body + 3-body potential). The hydration structure of In3+ in the first shell was relatively stable.

Molecular Docking and Dynamics Simulation for Searching Anti-Cancer Compounds of Piperlongumine Derivatives that Have Potential as an Inhibitor Against MAO-B (Monoamine Oxidase B) Suwardi Suwardi; Agus Salim; Raden Rara Fadhila Kirana Nugrahani; Yolanda Amalia
Indonesian Journal of Chemistry and Environment Vol 6, No 1 (2023): JUNE 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i1.61429

The docking of the piperlongumine molecule and its derivatives has been carried out to find molecules that have the potential as anti-cancer. A total of 18 ligands were docked to the 2v5z protein using the autodock4 and autodock vina programs. The binding energies of piperlongumine and piperlongumine derivatives [R1 = CH3 and R2 = H] were -8.6 kcal/mol and -9.3 kcal/mol, respectively. Based on molecular dynamics simulations, the hydrogen bond interaction fraction was dominated by GLN 206 residue in both the SAG (88%) and piperlongumine derivatives ((R1=CH3, R2 = H)(93%) ligand, for this reason, this piperlongumine derivative molecule is predicted to have potential as MAO B inhibitor.

Scientific attitudes in chemistry learning: A systematic literature review Intan Shanderi; Suwardi Suwardi
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 2 (2023): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v15i2.48881

This systematic review analysis study aimed to examine the scientific attitudes in chemistry learning. The method used a Systematic Literature Review which consists of 5 stages adopted from Denyer and Tranfield. The main criteria for the selection of articles are scientific attitude in the field of chemistry learning with a period of 2012 until 2023 from the well-known national and international database. There were 29 articles were obtained that fit into the criteria. The article’s aspect focused on the parameters such as aim, sample level, instructional method, instruments, and chemistry subject. The result showed that the attitude scale is the most instrument that can be used to measure scientific attitude in chemistry learning. Meanwhile, PBL has become the most instructional method that has been used to enhance scientific attitude. Moreover, the studies mostly aim to investigate the influence of teaching methods on scientific attitudes. Most researchers involve high school students in scientific attitude research on analytical chemistry concepts. There are different codes for each theme of scientific attitudes. Thus, the review helps to evaluate the instrument and instructional methods in chemistry learning and also provides recommendations for examining students’ scientific attitudes in further explorations.Keywords: Chemistry learning; Instructional method; Instrument; Scientific attitudes

Virtual Screening, Pharmacokinetic Prediction, Molecular Docking and Dynamics Approaches in the Search for Selective and Potent Natural Molecular Inhibitors of MAO-B for the Treatment of Neurodegenerative Diseases Suwardi Suwardi; Agus Salim; Joanda Ario Yudha Mahendra; Daniel Bima Aji Wijayanto; Nurul Azqiya Rochiman; Sigit Khoirul Anam; Nur Hikmah
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.68338

This research aims to find natural product compounds that have the potential to act as MAO-B inhibitors that are useful in the treatment of neurodegenerative diseases, through the stages: a) Virtual Screening, b) Molecule Docking, c) Pharmacokinetic and toxicity prediction, and d) Simulation approach Molecular dynamics.The research steps include the following steps: a) searching for molecules in the ZINC15 data base that are similar to the natural ligand molecule (safinamide) obtained from the protein data bank (PDB code: 2v5z) and the control ligand L-DOPA. A total of 481 molecules were downloaded from the data base and then molecular docking was carried out using the autodock program on the MAO-B target in the 2v5z receptor. After carrying out the docking analysis, 48 ligand molecules were selected which had a binding affinity (DG/kcal/mol) that was smaller than the DG of the natural ligand and the control ligand and nine (9) ligand molecules were taken to be tested: (i) ligand-ligand interactions MAO-B with discovery studio, (ii) Absorption, Distribution, Metabolism and Excretion properties with SwissADME and (iii) toxicity using PROTOX-II. Molecular dynamics simulations were carried out to determine the stability of ligands in proteins. Ligand complex [CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1]-2v5z was chosen to simulate for 100 ps. The results of the molecular docking study showed that there were 9 molecules that had binding affinity values that were smaller than the binding affinity of the natural ligand and the control ligand. Ligand and residue interactions are dominated by hydrogen bonds, donor-donor and pi-pi stacked interactions. Based on SwissADME, the Blood Brain Barrier (BBB) permeant on ligand number 1, 2, 3, 5, 6, and 9 shows that it is orally active and cannot pass through the BBB and will not cause any side effects, whereas ligand number 4, 7, 8, 10, and 11 can cross the BBB and may cause side effects. Based on the results of toxicity prediction (PROTOX-II), it is known that there are four (4) ligands in class V, five (5) ligands in class IV and the rest in class II. Hepatotoxicity, carcinogenicity, and Phosphoprotein (Tumor Suppressor) p53 in eleven ligands are predicted to be inactive and have a small probability. The stimulated [CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1]-2v5z complex apparently still shows ligand-protein fluctuations so that its conformation is still unstable.

Pengembangan Kolaborasi antara Pendidikan Kimia UNY dengan S1 Farmasi Fakultas Farmasi USD melalui Drafting Paten dan Hak Cipta Bidang Green Chemistry Eli Rohaeti; Isana Supiah Yosephine Louise; Endang Widjajanti Laksono; Suwardi Suwardi; Kun Sri Budiasih; K.H. Sugiyarto; Faiz Ilham Pratama; Nur Abdul Goni; Sukisman Purtadi; Rasamimanana Joronavalona; Adilah Afikah; Febri Saputri
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol 8, No 1 (2024): Vol 8, No 1 (2024)
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v8i1.66978

Kolaborasi dilakukan dengan Perguruan Tinggi mitra yang memiliki jumlah kegiatan-kegiatan penelitian cukup banyak serta berpotensi paten dan jenis HKI lainnya. Permasalahan yang dijumpai di PT mitra yaitu masih rendahnya jenis penelitian berpotensi paten dan masih rendahnya jumlah luaran penelitian dalam bentuk paten dan paten sederhana maupun hak cipta. Dengan demikian kolaborasi dapat dilakukan melalui kegiatan seleksi berbagai penelitian yang sudah dilakukan oleh PT mitra dan analisis penelitian yang berpotensi paten maupun jenis HKI lainnya, serta bimbingan teknis drafting paten. Solusi terhadap permasalahan yang dihadapi PT mitra yaitu melalui pengembangan ide-ide penelitian berbasis sumber daya alam lokal serta pendampingan pemilihan kegiatan-kegiatan penelitian yang berpotensi paten. Selanjutnya solusi terhadap permasalahan PT mitra terkait masih rendahnya jumlah luaran penelitian berupa HKI (paten, paten sederhana, hak cipta, dan sejenisnya), yaitu melalui kegiatan bimbingan teknis penyusunan drafting paten. Kegiatan PPM yang telah dilakukan dapat memberikan pengetahuan tentang penelitian-penelitian bidang green chemistry berbasis sumber daya alam lokal PT mitra yang berpotensi paten dan jenis HKI lainnya sehingga mitra dapat membuat sendiri berbagai penelitian green chemistry, menambah wawasan bagi mitra tentang cara melakukan penyusunan (drafting) paten berdasarkan penelitian-penelitian yang sudah dilakukan ditunjukkan dengan adanya peningkatan nilai pretes dan postes, dapat menumbuhkan semangat dan kemandirian mahasiswa mitra untuk membuat produk berbasis sumber daya alam lokal dan berwawasan lingkungan berdasarkan saran yang diberikan, dan meningkatkan kesadaran mitra untuk lebih peduli lingkungan dengan memanfaatkan sumber daya alam lokal menjadi sesuatu yang bermanfaat.

Co-Authors Adilah Afikah Agus Salim Crys Fajar Partana Daniel Bima Aji Wijayanto Eli Rohaeti Endang Widjajanti Laksono FX Faiz Ilham Pratama Febri Saputri Intan Shanderi Isana Supiah Yosephine Louise Joanda Ario Yudha Mahendra K.H. Sugiyarto Kun Sri Budiasih Marfuatun, Marfuatun Muhammad Syaekhul Anam Novan A. A. Permana Nur Abdul Goni Nur Hikmah Nurul Azqiya Rochiman Raden Rara Fadhila Kirana Nugrahani Rasamimanana Joronavalona Sigit Khoirul Anam Sukisman Purtadi Yolanda Amalia

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