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All Journal Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Organisms: Journal of Biosciences
Rahmawati Januar
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Mathematics Medicine & Pharmacology Veterinary

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STRUKTUR MIKROSKOPIS HATI TIKUS PUTIH (Rattus novergicus) AKIBAT PEMBERIAN EKSTRAK TANAMAN Tristaniopsis whiteana Griff. Rahmawati Januar; Yusfiati '; Fitmawati '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Pelawan plant (Tristaniopsis whiteana Griff.) is used by people for blood cleaner after postpartum. Scientifically, pelawan is proven as antiurolithiasis agent. However, its secondary metabolite toxicity is still unknown. This study aimed to know the histological structure of liver tissue of white rat after being given pelawan extract. This study use 8 white rats that were divided into four groups. Control group was given food and water, P1 was given food and inducer solution (mixture from ethylene glycol and ammonium chloride), P2 group was given ethanol extract of pelawan leaves with inducer solution, and P3 group was given ethanol extract of pelawan leaves. Histological slides of white rat liver were made using paraffin method, stained with Hematoxylin-Eosin (HE). Result showed that the liver of white rat changed. Therefore, the treatment of inducer solution and ethanol extract of pelawan leaves was toxic because it changed the histopatologycal part.
In silico Structural Characterization of Inflammasome Receptors in Multi Organ Dysfunction Syndrome Aritonang, Erfan Andrianto; Muhammad Farid Rizal; Rahmawati Januar
ORGANISMS: JOURNAL OF BIOSCIENCES Vol. 6 No. 1 (2026): Organisms: Journal of Biosciences
Publisher : Pusat HKI, Paten, dan Publikasi Ilmiah Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/mms81p41

Abstract

Multi organ dysfunction syndrome involves multiple inflammatory receptors that regulate multi-organ damage. This study aims to analyze the structural characteristics of multireceptor inflammasome through the in silico method. The receptors analyzed were TNFR1, IL-1, IL-6, and NLRP3. The structural characteristics analyzed include affinity energy, RMSD, inhibition constants, and amino acid interactions. The results showed that NLRP3 had the most negative affinity energy value compared to others, which was -9,4 kcal/mol and an inhibition constant of 0,237 μM. The validity of the NLRP3 model was confirmed to be very stable with an RMSD value of 1,1709 Å, while other receptors showed a structural deviation of > 6 Å. Amino acid interaction analysis showed that the majority of interactions occur hydrophobic more than other receptors, and there are also hydrogen bonds. Based on the results of the study, it is known that NLRP3 has the best structure in silico, so it can be used as a reference for receptor models in follow-up research related to pathogenesis and anti-MODS drug development studies 
Co-Authors Aritonang, Erfan Andrianto Fitmawati ' Muhammad Farid Rizal Yusfiati Yusfiati