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All Journal ACTA VETERINARIA INDONESIANA Media Kedokteran Hewan Jurnal Medik Veteriner Jurnal Ilmu Peternakan Terapan Journal of Applied Plant Technology Jurnal Veteriner dan Biomedis Agrocentrum
Aritonang, Erfan Andrianto
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Ekstrak Kecoak Periplaneta americana sebagai Antiinflamasi Sistemik pada Tikus Putih Model SIRS Aritonang, Erfan Andrianto
Acta VETERINARIA Indonesiana Vol. 12 No. 2 (2024): Juli 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.12.2.119-124

Abstract

Systemic inflammatory response syndrome (SIRS) merupakan fenomena hiperinflamsi sistemik yang diperantarai oleh respon imunitas bawaan akibat paparan infeksi ataupun non infeksi. Penelitian ini bertujuan menganalisis efektifitas antiinflamasi ekstrak kecoak P. americana melalui tampilan klinis hewan model. Induksi SIRS melalui cecal ligation and puncture (CLP). Hewan model menggunakan tikus putih galur Sprague Dawley jantan umur 10 minggu sebanyak 20 ekor yang mendapatkan bedah CLP dan diterapi menggunakan NaCl 0,9% 0,2 ml/ekor, dexamethasone 0,75 mg/kg BB, ekstrak kecoak P. americana (EKP) 50 mg/kg BB, dan 100 mg/kg BB. Pemberian terapi dilakukan secara per oral pada 24 dan 48 jam setelah CLP. Hasil penelitian variabel suhu tubuh menunjukan tidak terdapat perbedaan signifikan antara kelompok yang diberi NaCl 0,9%, dexamethasone, dan EKP 50 mg/kg BB (P > 0.05), namun berbeda signifikan (suhu lebih rendah dibawah normal) dengan kelompok EKP 100 mg/kg BB (P < 0.05). Variabel jumlah napas, detak jantung, dan total leukosit tidak menujukan perbedaan signifikan antara setiap kelompok (P > 0.05). Presentase bertahan hidup hingga akhir penelitian kelompok yang diterapi menggunakan NaCl 0,9%, dexamethasone, EKP 50 mg, dan EKP 100 mg masing-masing sebesar 60%, 80%, 100%, dan 60%. EKP 50 mg/Kg BB memiliki potensi sebagai antiinflmasi sistemik pada tikus putih model SIRS
The Effectiveness of Three Types of Tissue Culture Media on the Growth and Jasmone Content of Jasmine (Jasminum sambac) Callus: Efektivitas Tiga Jenis Media Kultur Jaringan Terhadap Pertumbuhan dan Kandungan Melati Kalus Melati (Jasminum sambac) Aritonang, Erfan Andrianto; Widya, Surya Ari
Journal of Applied Plant Technology Vol 3 No 1 (2024): Journal of Applied Plant Technology (JAPT)
Publisher : Agrotechnology Study Program, Faculty of Agriculture, Wijaya Kusuma Surabaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/bjfqa814

Abstract

Jasmine is a herbaceous plant that has its own charm, especially its fragrant aroma, so the demand for jasmine extract is very popular. With the large industrial demand as a raw material, it is necessary to study the growth, development and content of jasmone in jasmine callus on 3 types of media in order to increase the content and efficiency of media use. This research aims to determine the growth, development and jasmone content in Jasminum sambac jasmine callus grown on MS (Murashige and Skoog), VW (vacin and Went), and NT (Nagata and Takebe) media in vitro. This research was carried out using a Completely Randomized Design (CRD), repeated 5 times and in each replication there were 3 samples. The treatment is as follows: 1. MS media (M1); 2. VW Media (M2); 3. Media NT(M3). Using parameters for observing the quantity and quality of callus by scoring once a week and analyzing secondary metabolites. From the results of observing the quantity, quality and analysis of secondary metabolites with modified treatment on MS, VW and NT media, it can be concluded that the quantity of callus is not significantly different, but the quantity of callus on NT (Nagata and Takebe) M3 media tended to be better than MS (Murashige and Skoog) M1 and VW (Vacin and Went) M2 media, while the results of callus quality from all media tended to be compact and the results of secondary metabolite content in the media treatment NT (Nagata and Takebe) M3 produced better jasmone content (1.22%) compared to MS (Murashige and Skoog) M1 and VW (Vacin and Went) M2 media.
Bedah Reposisi Hernia Perineal pada Kucing Betina Apritya, Desty; Widyawati, Ratna; Aritonang, Erfan Andrianto; Djawa, Marselinus Ndilu Landu; Saputra, Fauzi; Dayanti, Ika Ayu Anita
Jurnal Medik Veteriner Vol. 3 No. 2 (2020): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol3.iss2.2020.277-282

Abstract

Kucing betina berusia ±1 tahun dengan gejala klinis dysuria, konstipasi, pada bagian perineal terdapat kebengkakan dengan konsistensi kenyal disertai luka. Hasil pemeriksaan darah menunjukkan peningkatan monosit sedangkan hasil pemeriksaan ultrasonografi pada kebengkakan menunjukan gambaran anechogenic berisi cairan. Hasil aspirasi teridentifikasi cairan tersebut adalah urin, sehingga kucing tersebut dapat didiagnosis hernia perineal dengan refleksi vesika urinaria. Tahapan operasi meliputi herniorraphy, reposisi vesika urinaria, dan hernioplasti. Terapi sistemik pasca operasi yaitu Amoxicilin 20 mg/kgBB q12h, Asam mefenamat 16 mg/kg BB q12h, dan multivitamin ½ tab q12h selama tujuh hari. Terapi menggunakan topikal menggunakan povidone iodine 10% dan die da yao jing®. Kucing menunjukkan aktifitas normal setelah 7 hari perawatan.
Kajian Pertumbuhan dan Hasil Okra (Abelmoschus esculentus L.) dengan Aplikasi Beberapa Jenis Pupuk Kandang: Study Growth and Yield of Okra (Abelmoschus esculentus L.) with Manure Application Haryanta, Dwi; Widya, Surya Ari; Aritonang, Erfan Andrianto
Agrocentrum Vol. 2 No. 1 (2024): Agrocentrum
Publisher : Agriculture Faculty - UPN "Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/agrocentrum.v2i1.19

Abstract

Many livestock waste has not been utilized, and is even left unused, which will harm environmental health. This research aims to determine the effect of types of manure on the growth and yield of Okra plants (Abelmoschus esculantus L.), and to determine the optimum dose of each type of manure as a reference in recommendations for the use of manure for okra plants. . The single factor experiment used a randomized completly block design (RCBD) with 4 treatments repeated 5 times, namely P0 (without drum fertilizer), P1 (cow manure), P2 (chicken manure), and P3 (goat manure). The results of the research showed that cow manure gave the best results even though it was not significantly different from goat manure, with a production of 12.63 tons / hectare, while the smallest effect was even lower than the control, namely the chicken drum manure treatment. In testing manure and compost (solid organic fertilizer) the maturity level must be the same (mature) by looking at the C/N ratio value.
Nilai RBC dan RDW Tikus Model Sepsis yang Diterapi dengan Ekstrak Kecoa Periplaneta americana Aritonang, Erfan Andrianto; Gunanti; Rini Madyastuti Purwono; Supriyono
Jurnal Veteriner dan Biomedis Vol. 2 No. 2 (2024): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.2.74-78.

Abstract

Red Blood Cell (RBC) dan Red blood cell Distribution Width (RDW) merupakan variabel hematologi yang banyak dikaji sebagai biomarker sepsis dan prediktor mortalitas pasien sepsis yang dirawat secara intensif. Penelitian ini bertujuan untuk menanalisis potensi EKP sebagai terapi sepsis tikus model melalui variabel nilai RBC dan RDW. Ekstraksi kecoa P. americana menggunakan metode maserasi dengan etanol 70%. Induksi sepsis pada tikus model menggunakan metode bedah cecal ligation and puncture. Tikus model sepsis dibagi menjadi empat kelompok terapi yaitu NaCl 0,9%, deksametason 0,75 mg/kg, EKP 50 mg/kg, dan EKP 100 mg/kg. Terapi dilakukan secara per oral 24 dan 36 jam setelah bedah CLP. Rataan nilai RBC setelah induksi sepsis dan diterapi masing-masing sebesar 6,76; 7,82; 8,01; dan 6,80. Persentase nilai RDW setelah induksi sepsis dan diterapi masing-masing sebesar 14,7; 13,75; 13,88; dan 14,26. Hasil penelitian menunjukan tidak adanya perbedaan signifikan antara setiap kelompok (P > 0,05), namun nilai RBC dan RDW lebih baik pada kelompok yang diterapi dengan deksametason dan EKP 50 mg/kg. Kesimpulan dari penelitian ini adalah EKP 50 mg/kg berpotensi sebagai terapi sepsis berdasarkan nilai RBC dan RDW tikus model sepsis.
Anti-atherosclerosis potential activity from Alphitobius diaperinus: a molecular docking study on NLRP3 receptor Hasibuan, Firdaus; Aritonang, Erfan Andrianto
Jurnal Ilmu Peternakan Terapan Vol 8 No 2 (2025): Jurnal Ilmu Peternakan Terapan
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/jipt.v8i2.5814

Abstract

This study aimed to analyze the potential activity anti-atherosclerosis of Alphitobius diaperinus larvae using molecular docking. The target receptor used was NLRP3, with β-sitosterol and campesterol as the test ligands, and simvastatin as the control ligand. The results showed that the binding affinity energies of β-sitosterol and campesterol were more negative than simvastatin, with values of -9.3, -9.3, and -8.6 kcal/mol, respectively. The inhibition constants of β-sitosterol and campesterol were lower than that of simvastatin, with values of 0.213, 0.213, and 0.494 μM, respectively. The percentage of binding site similarity with the native ligand for β-sitosterol and campesterol was 60%, while simvastatin showed 0%. Molecular probability analysis using Lipinski's rules revealed that simvastatin met all five criteria, whereas β-sitosterol and campesterol met four criteria. The LD50 analysis indicated that simvastatin fell under category III, while β-sitosterol and campesterol were in category I. All three molecules β-sitosterol, campesterol, and simvastatin were found to be non-carcinogenic. The conclusion of this study was β-sitosterol and campesterol from A. diaperinus larvae have potential as anti-atherosclerosis candidates.
Systemic Anti-inflammatory Activity of American Cockroach (Periplaneta americana) Extract: A Molecular Docking Study Aritonang, Erfan Andrianto; Gunanti; Purwono, Rini Madyastuti; Supriyono
Media Kedokteran Hewan Vol. 35 No. 2 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i2.2024.105-112

Abstract

Surgery can trigger systemic inflammatory response syndrome. This study aims to determine the effectiveness of Periplaneta americana cockroach extract as an oral systemic anti-inflammatory agent using molecular docking. The molecular docking method consisted of five steps. The first step was preparing the TNF-α converting enzyme (TACE) receptor as a native ligand, dexamethasone as a control ligand, and three test ligands of Periplaneta americana cockroach extract. The second step was docking preparation. The third step was analyzing Gibbs free energy (∆G) and root mean square deviation (RMSD). The fourth step was docking the test and control ligands with TACE. The fifth step was analyzing ∆G, inhibition constant (Ki), visualization of two- and three-dimensional interactions, percentage of binding site similarity (%BSS), and the rule of five (Ro5) on test ligands. The ∆G results for the native, control, and test ligands 1, 2, and 3 were -12.8, -7.1, -7.7, -6.9, and -9.0 kcal/mol, respectively. The Ki values for the native, control, and test ligands 1, 2, and 3 were 4.091, 6.205, 2.253, 9.521, and 2.507 µM, respectively. The results of the Ro5 analysis suggested that the three test ligands satisfied Lipinski's rule of five. This study concluded that Periplaneta americana cockroach extract is an effective oral systemic anti-inflammatory agent.
Co-Authors Apritya, Desty Dayanti, Ika Ayu Anita Djawa, Marselinus Ndilu Landu Dwi Haryanta Gunanti Hasibuan, Firdaus Madyastuti, Rini Ratna Widyawati Saputra, Fauzi SUPRIYONO Supriyono, Supri Widya, Surya Ari