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Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus Nengah Tegar Saputra; I Nyoman Suartha; Anak Agung Gde Oka Dharmayudha
Buletin Veteriner Udayana Vol. 10 No. 2 Agustus 2018
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.24 KB) | DOI: 10.24843/bulvet.2018.v10.i02.p02

Abstract

Trend of metabolic diseases like diabetes mellitus were growth up, with morbility and mortality rate are higher. Most of research about diabetes mellitus are used to rat. Experimental diabetagonic agent was use like aloksan and streptozocin (STZ). The side effect of STZ are less than aloksan. The purpose of this study was to see the response of white rats (Rattus norvegicus) male against streptozotocin agent to make the rats in the experimental conditions of diabetes mellitus. Injection of streptozotocin agent carried by intra peritoneal with dose of 45 mg/kg. White rats have sarver before induction STZ. Level of blood glucose are measure before induction STZ (day 0) and third day after induction STZ. The number of rats is 88 individuals. The results showed that rats provide a response to the increase in blood glucose as an indication of experimental diabetes mellitus which is indicated by a percentage value. White rats experiencing hyperglycemia as much as 54,8 % with the details of 21.5 % mild, 11.8 % moderate and 21.5 % by weight . These results indicate that a very precise Streptozotocin agent used to make experimental animals in the experimental conditions of diabetes mellitus.
Co-Authors Anak Agung Gde Oka Dharmayudha I Nyoman Suartha