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All Journal E-Jurnal Medika Udayana Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Rania Ayu Permata Putri Kornia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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PREVALENSI DAN PROFIL HERPES ZOSTER DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR PERIODE APRIL 2015 SAMPAI MARET 2016 Rania Ayu Permata Putri Kornia; I Gusti Ayu Agung Dwi Karmila
E-Jurnal Medika Udayana Vol 9 No 8 (2020): Vol 9 No 08(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Herpes zoster atau yang juga sering disebut shingles merupakan penyakit yang disebabkan reaktivasi virus varisela zoster laten di akar sensoris dorsal atau ganglia saraf kranialis, dan biasanya bermanifestasi sebagai ruam vesikuler yang nyeri di sepanjang distribusi dermatom. Beberapa faktor risiko terjadinya herpes zoster adalah usia tua, orang yang imunokompromais, dan jenis kelamin wanita. Tujuan dari penelitian ini adalah untuk mengetahui prevalensi dan profil herpes zoster di RSUP Sanglah Denpasar periode April 2015 sampai Maret 2016. Penelitian ini bersifat deskriptif retrospektif. Sampel penelitian ini adalah seluruh pasien yang terdiagnosis herpes zoster pada rekam medis di Rumah Sakit Umum Pusat Sanglah Denpasar periode April 2015 sampai Maret 2016. Data penelitian diambil dari rekam medis di RSUP Sanglah Denpasar periode April 2015 sampai Maret 2016. Hasil penelitian didapatkan prevalensi herpes zoster di RSUP Sanglah Denpasar periode April 2015 sampai Maret 2016 sebanyak 28 penderita. Laki-laki 60,7% dan perempuan 39,3%, usia terbanyak adalah 45-64 tahun (50%), pekerjaan terbanyak adalah pekerja swasta dan ibu rumah tangga (masing-masing 21,4%), lokasi lesi tersering adalah torakalis (32,1%), penyakit penyerta terbanyak adalah DM dan hipertensi (masing-masing 10,7%), komplikasi terbanyak adalah PHN (14,3%), antivirus yang paling banyak diberikan adalah asiklovir (82,1%), dan lebih banyak penderita yang diberikan pengobatan antivirus lebih dari 72 jam sejak munculnya gejala (57,1%). Dapat disimpulkan bahwa kejadian herpes zoster masih banyak terjadi di masyarakat dan cenderung meningkat. Kata Kunci: herpes zoster, prevalensi, profil
The Unseen Danger: A Meta-Analysis of Bystander Injuries in Firework-Related Ocular Trauma Rania Ayu Permata Putri Kornia; I Made Ady Wirawan; I Gusti Ayu Made Juliari; Ida Ayu Ary Pramita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1409

Abstract

Background: Firework-related ocular trauma represents a significant, preventable cause of severe vision loss, with incidence rates peaking during global cultural and national festivals. While the risks to active firework users are well-established, the burden of injury sustained by passive spectators, or bystanders, remains poorly quantified. This study aimed to synthesize global data to define the magnitude of this unseen danger. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, EMBASE, and Web of Science were searched for studies published between January 2015 and December 2025 that reported separable data on firework-related ocular injuries in bystanders and operators. A random-effects model calculated the pooled proportion of bystander injuries. Secondary outcomes included pooled odds ratios (ORs) for open globe injury (OGI) and severe vision loss (SVL; Visual Acuity <3/60). Results: Eleven studies, encompassing 2,440 patients, met the inclusion criteria. This meta-analysis, despite significant heterogeneity in the source data (I² = 89%), suggests that nearly half of all victims were bystanders, with a pooled proportion of 47.5% (95% CI: 41.8%–53.2%). Bystanders had significantly lower odds of sustaining an OGI compared to operators (pooled OR: 0.72, 95% CI: 0.58–0.90). However, the odds of suffering permanent SVL were not statistically different between the two groups (pooled OR: 0.91, 95% CI: 0.73–1.14), indicating a comparable risk of blinding injury. Conclusion: These findings must be interpreted with caution due to high inter-study heterogeneity and unmeasured clinical confounders. Nonetheless, the analysis strongly suggests that the risk to bystanders is unacceptably high and that public health paradigms focused solely on operator safety are insufficient. This study underscores the urgent need for prospective, standardized data collection and a shift in prevention strategies toward protecting passive spectators.
The Unseen Danger: A Meta-Analysis of Bystander Injuries in Firework-Related Ocular Trauma Rania Ayu Permata Putri Kornia; I Made Ady Wirawan; I Gusti Ayu Made Juliari; Ida Ayu Ary Pramita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1409

Abstract

Background: Firework-related ocular trauma represents a significant, preventable cause of severe vision loss, with incidence rates peaking during global cultural and national festivals. While the risks to active firework users are well-established, the burden of injury sustained by passive spectators, or bystanders, remains poorly quantified. This study aimed to synthesize global data to define the magnitude of this unseen danger. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, EMBASE, and Web of Science were searched for studies published between January 2015 and December 2025 that reported separable data on firework-related ocular injuries in bystanders and operators. A random-effects model calculated the pooled proportion of bystander injuries. Secondary outcomes included pooled odds ratios (ORs) for open globe injury (OGI) and severe vision loss (SVL; Visual Acuity <3/60). Results: Eleven studies, encompassing 2,440 patients, met the inclusion criteria. This meta-analysis, despite significant heterogeneity in the source data (I² = 89%), suggests that nearly half of all victims were bystanders, with a pooled proportion of 47.5% (95% CI: 41.8%–53.2%). Bystanders had significantly lower odds of sustaining an OGI compared to operators (pooled OR: 0.72, 95% CI: 0.58–0.90). However, the odds of suffering permanent SVL were not statistically different between the two groups (pooled OR: 0.91, 95% CI: 0.73–1.14), indicating a comparable risk of blinding injury. Conclusion: These findings must be interpreted with caution due to high inter-study heterogeneity and unmeasured clinical confounders. Nonetheless, the analysis strongly suggests that the risk to bystanders is unacceptably high and that public health paradigms focused solely on operator safety are insufficient. This study underscores the urgent need for prospective, standardized data collection and a shift in prevention strategies toward protecting passive spectators.
Co-Authors I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Made Juliari I Made Ady Wirawan Ida Ayu Ary Pramita