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All Journal E-Jurnal Medika Udayana Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Ni Wayan Saka Rahayu
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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PENGARUH EKSTRAK BIJI PEPAYA MUDA (Carica papaya L.) TERHADAP KOPULASI DAN JUMLAH ANAKAN MENCIT (Mus musculus L.) Ni Wayan Saka Rahayu; Bagus Komang Satriyasa; Made Jawi; Ni Wayan Sucindra Dewi
E-Jurnal Medika Udayana Vol 10 No 8 (2021): Vol 10 No 08(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i8.P12

Abstract

Latar Belakang: Upaya pemerintah untuk mengatur kepadatan jumlah penduduk adalah dengan menggunakan kontrasepsi. Menurut data BKKBN, penggunaan kontrasepsi pada pria lebih sedikit dibandingkan perempuan. Rendahnya partisipasi pria dalam Keluarga Berencana dikarenakan ketersediaan kontrasepsi pria yang minimal. Kontrasepsi pria bisa didapat dari bahanaalam seperti biji pepaya muda (Carica papaya L.) memiliki kandungan bersifat anti fertilitas. Hasil dan Pembahasan: Penelitian ini menggunakan metode True Experimental Post Test Only Control Group Design. Sampel dibagi dalam 3 kelompok yakni kelompok kontrol (P0), kelompok perlakuan 1 (P1) dan kelompok perlakuan 2 (P2) dengan masing-masing jumlah sampel 10 ekor mencit (Mus Musculus L.) setiap kelompok. Data dianalisis menggunakan SPSS. Ekstrak biji pepaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit, didapatkan nilai p 0,342 (p>0,05). Ekstrak biji pepaya muda (Carica papaya L.) berpengaruh signifikan terhadap jumlah anakan mencit (Mus Musculus L.) didapatkan nilai p <0,001. Ekstrak biji papaya muda (Carica papaya L.) berpengaruh signifikan terhadap kategori kehamilan mencit (Mus Musculus L.) didapatkan nilai p <0,001. Ekstrak biji papaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit disebabkan oleh regulasi umpan balik negatif sistem hipotalamus-hipofisis, sehingga hormon testosteron masih dalam kadar normal. Ekstrak biji pepaya muda (Carica papaya L.) berpengaruh terhadap jumlah anakan mencit disebabkan oleh kandungan ekstrak biji pepaya muda (Carica papaya L.) yang bersifat anti fertilitas. Kesimpulan : Ekstrak biji pepaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit (Mus Musculus L.) , sedangkan berpengaruh terhadap jumlah anakan mencit (Mus Musculus L.) Kata kunci : Ekstrak biji pepaya muda, kopulasi mencit, jumlah anakan mencit
Destructive Thyroiditis: A Rare and Perplexing Complication of Lithium Therapy in Bipolar Disorder Ni Wayan Saka Rahayu
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1459

Abstract

Background: Lithium is a cornerstone therapy for Bipolar I Disorder, yet its use necessitates vigilant monitoring for adverse drug reactions (ADRs). While lithium-induced hypothyroidism is a well-documented complication, the emergence of thyrotoxicosis secondary to destructive thyroiditis is a rare and diagnostically challenging event. This report presents a systematic analysis of a case of suspected lithium-induced thyroiditis notable for its paradoxical clinical presentation as a severe depressive episode. Case presentation: A 33-year-old female with a 10-year history of Bipolar I Disorder, stable on lithium for two years, was admitted with a severe depressive episode and active suicidal ideation. The onset of her psychiatric decompensation was temporally correlated with a diagnosis of thyrotoxicosis (suppressed TSH <0.005 uIU/mL; elevated FT4 >7.77 ng/dL). A formal causality assessment using the Naranjo Adverse Drug Reaction Probability Scale yielded a score of 6, indicating a "probable" relationship between lithium and the thyroiditis. Critically, the thyrotoxic state, which conventionally mimics mania, presented atypically as severe depression. Conclusion: This case of probable lithium-induced destructive thyroiditis, presenting paradoxically with severe depression, underscores the critical need for a high index of suspicion for iatrogenic endocrinopathies in patients on lithium who exhibit any mood destabilization. A systematic approach to ADR assessment is essential to guide appropriate clinical management in such complex presentations.
Destructive Thyroiditis: A Rare and Perplexing Complication of Lithium Therapy in Bipolar Disorder Ni Wayan Saka Rahayu
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1459

Abstract

Background: Lithium is a cornerstone therapy for Bipolar I Disorder, yet its use necessitates vigilant monitoring for adverse drug reactions (ADRs). While lithium-induced hypothyroidism is a well-documented complication, the emergence of thyrotoxicosis secondary to destructive thyroiditis is a rare and diagnostically challenging event. This report presents a systematic analysis of a case of suspected lithium-induced thyroiditis notable for its paradoxical clinical presentation as a severe depressive episode. Case presentation: A 33-year-old female with a 10-year history of Bipolar I Disorder, stable on lithium for two years, was admitted with a severe depressive episode and active suicidal ideation. The onset of her psychiatric decompensation was temporally correlated with a diagnosis of thyrotoxicosis (suppressed TSH <0.005 uIU/mL; elevated FT4 >7.77 ng/dL). A formal causality assessment using the Naranjo Adverse Drug Reaction Probability Scale yielded a score of 6, indicating a "probable" relationship between lithium and the thyroiditis. Critically, the thyrotoxic state, which conventionally mimics mania, presented atypically as severe depression. Conclusion: This case of probable lithium-induced destructive thyroiditis, presenting paradoxically with severe depression, underscores the critical need for a high index of suspicion for iatrogenic endocrinopathies in patients on lithium who exhibit any mood destabilization. A systematic approach to ADR assessment is essential to guide appropriate clinical management in such complex presentations.
Co-Authors Bagus Komang Satriyasa I Made Jawi Ni Wayan Sucindra Dewi