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All Journal E-Jurnal Medika Udayana Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Anak Agung Putri Satwika
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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UJI DIAGNOSTIK TES SEROLOGI WIDAL DIBANDINGKAN DENGAN TES IGM ANTI SALMONELLA TYPHI SEBAGAI BAKU EMAS PADA PASIEN SUSPECT DEMAM TIFOID DI RUMAH SAKIT SURYA HUSADHA PADA BULAN JANUARI SAMPAI DENGAN DESEMBER 2013 Anak Agung Putri Satwika; A.A. Wiradewi Lestari
E-Jurnal Medika Udayana vol 4 no 8(2015):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

tifoid merupakan penyakit infeksi akut sistemik yang disebabkan oleh bakteri gram negatif Salmonella enterica serotype Typhi (Salmonella typhi), yang hingga saat ini masih memiliki angka morbiditas dan mortaliatas yang tinggi di dunia khususnya di negara berkembang salah satunya Indonesia. Metode diagnosis cepat dan tepat perlu dilakukan sedini mungkin pada pasien yang dicurigai mengalami demam tifoid sehingga pasien segera mendapatkan penanganan yang tepat. Tes Widal dan tes IgM Anti Salmonella typhi merupakan pemeriksaan penunjang yang sering digunakan untuk menegakkan diagnosis demam tifoid. Berdasarkan penelitian sebelumnya, diketahui bahwa tes IgM Anti Salmonella typhi memiliki sensitivitas, spesifisitas, PPV dan NPV yang tinggi. Penelitian ini merupakan penelitian uji diagnostik dengan menggunakan rancangan penelitian cross-sectional, yang dilakukan di Rumah Sakit Surya Husadha pada Bulan Januari sampai dengan Desember 2013. Tujuan penelitian adalah untuk mengetahui sensitivitas, spesifisitas, PPV dan NPV tes Widal jika dibandingkan dengan tes IgM Anti Salmonella typhi sebagai baku emas. Pada penelitian diperoleh bahwa dari 203 sampel, terdapat 17 sampel (8%) yang positif dan 186 sampel (92%) yang negatif terdapat antibodi terhadap antigen Salmonella typhi O. Sedangkan 27 sampel (13%) yang positif dan 176 sampel (87%) yang negatif terdapat antibodi terhadap antigen Salmonella typhi H. Pada tes IgM Anti Salmonella typhi, terdapat 104 sampel (51%) yang positif dan 99 sampel (49%) yang negatif. Dengan menggunakan cross tabulation maka diperoleh sensitivitas, spesifisitas, PPV dan NPV dari tes Widal khususnya untuk Salmonella typhi O secara berturut-turut yaitu 14,6%, 98%, 88,2% dan 52,7%. Sedangkan sensitivitas, spesifisitas, PPV dan NPV dari tes Widal khususnya untuk Salmonella typhi H secara berturut-turut yaitu 20%, 94%, 78% dan 53%.  
Metabolic and Hematologic Synergism in Idiopathic Intracranial Hypertension: Reversal of Bilateral Papilledema via Multidisciplinary Gynecological and Systemic Interventions Anak Agung Putri Satwika; Anak Agung Mas Putrawati Triningrat; Made Widhi Asih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1590

Abstract

Background: Idiopathic Intracranial Hypertension (IIH) conventionally presents with elevated intracranial pressure without structural etiologies, heavily associating with central adiposity. Emerging clinical frameworks recognize the intersecting roles of hematologic and metabolic abnormalities, notably iron deficiency anemia and hypovitaminosis D. Case presentation: A 41-year-old obese female (Body Mass Index 30.04 kg/m2) presented with progressive, painless bilateral visual blurring. Initial evaluation revealed a right eye visual acuity of 6/7.5 and a severely reduced left eye visual acuity of 1/60, alongside prominent bilateral papilledema and flame-shaped hemorrhages. The patient was incorrectly diagnosed with optic neuritis externally. Upon referral, rigorous evaluation successfully dismantled the misdiagnosis; intact pupillary reflexes, absence of a relative afferent pupillary defect, and an enlarged blind spot pointed definitively to papilledema. A lumbar puncture confirmed an elevated opening pressure of 340 mmH2O with normal cerebrospinal fluid composition. Targeted systemic profiling uncovered severe iron deficiency anemia (Hemoglobin 7.90 g/dL) driven by chronic menorrhagia from a uterine myoma, compounded by marked hypovitaminosis D. A tailored multidisciplinary intervention was initiated. A conservative acetazolamide dosage (500 mg/day) was utilized to minimize systemic stress, combined with cholecalciferol supplementation, ferrous sulfate, and a laparotomic myomectomy. One month post-operatively, hemoglobin normalized to 11.70 g/dL, visual acuity was fully restored to 6/6 bilaterally, and papilledema completely resolved. Conclusion: IIH is a multifactorial systemic syndrome. Prompt identification and aggressive correction of hematologic and metabolic drivers, including surgical eradication of hemorrhagic etiologies, are imperative for reversing intracranial hypertension and preventing permanent optic neuropathy.
Metabolic and Hematologic Synergism in Idiopathic Intracranial Hypertension: Reversal of Bilateral Papilledema via Multidisciplinary Gynecological and Systemic Interventions Anak Agung Putri Satwika; Anak Agung Mas Putrawati Triningrat; Made Widhi Asih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1590

Abstract

Background: Idiopathic Intracranial Hypertension (IIH) conventionally presents with elevated intracranial pressure without structural etiologies, heavily associating with central adiposity. Emerging clinical frameworks recognize the intersecting roles of hematologic and metabolic abnormalities, notably iron deficiency anemia and hypovitaminosis D. Case presentation: A 41-year-old obese female (Body Mass Index 30.04 kg/m2) presented with progressive, painless bilateral visual blurring. Initial evaluation revealed a right eye visual acuity of 6/7.5 and a severely reduced left eye visual acuity of 1/60, alongside prominent bilateral papilledema and flame-shaped hemorrhages. The patient was incorrectly diagnosed with optic neuritis externally. Upon referral, rigorous evaluation successfully dismantled the misdiagnosis; intact pupillary reflexes, absence of a relative afferent pupillary defect, and an enlarged blind spot pointed definitively to papilledema. A lumbar puncture confirmed an elevated opening pressure of 340 mmH2O with normal cerebrospinal fluid composition. Targeted systemic profiling uncovered severe iron deficiency anemia (Hemoglobin 7.90 g/dL) driven by chronic menorrhagia from a uterine myoma, compounded by marked hypovitaminosis D. A tailored multidisciplinary intervention was initiated. A conservative acetazolamide dosage (500 mg/day) was utilized to minimize systemic stress, combined with cholecalciferol supplementation, ferrous sulfate, and a laparotomic myomectomy. One month post-operatively, hemoglobin normalized to 11.70 g/dL, visual acuity was fully restored to 6/6 bilaterally, and papilledema completely resolved. Conclusion: IIH is a multifactorial systemic syndrome. Prompt identification and aggressive correction of hematologic and metabolic drivers, including surgical eradication of hemorrhagic etiologies, are imperative for reversing intracranial hypertension and preventing permanent optic neuropathy.
Co-Authors Anak Agung Mas Putrawati Triningrat Anak Agung Wiradewi Lestari Made Widhi Asih