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All Journal E-Jurnal Medika Udayana Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
I Gusti Bagus Mulia Agung Pradnyaandara
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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KARAKTERISTIK PASIEN KARSINOMA PARU DI RSUP SANGLAH DENPASAR TAHUN 2017-2018 I Gusti Bagus Mulia Agung Pradnyaandara; Herman Saputra; I Gusti Ayu Sri Mahendra Dewi; I Wayan Juli Sumadi
E-Jurnal Medika Udayana Vol 10 No 8 (2021): Vol 10 No 08(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i8.P13

Abstract

ABSTRAK Karsinoma paru adalah keganasan dengan angka mortalitas tertinggi di dunia pada penduduk pria. Karsinoma paru dimulai dari munculnya tumor supressor gen pada genom (onkogen). Inisiator yang mengubah tumor suppressor gen dengan delesi maupun insersi sebagian dari susunan pasangan basanya, adanya gen erbB1 dan atau erbB2 yang memiliki peran anti apoptosis. Sekitar delapan koma dua juta angka kematian pada tahun 2012 diakibatkan oleh karsinoma. Tujuan penelitian ini untuk mengetahui karakteristik pasien yang mengalami karsinoma paru di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitian deskriptif cross-sectional. Sampel terpilih adalah populasi yang telah melalui kriteria inklusi maupun eksklusi. Dengan perangkat lunak SPSS versi 22 data ini diolah. Hasil penelitian menunjukkan kasus karsinoma paru tersering pada kelompok usia 46-55 tahun sebesar 31,5% dimana jenis kelamin laki-laki adalah yang terbanyak (61,4%). Sebagian besar pasien karsinoma paru menderita tipe histopatologi dari adenocarcinoma (66,9%). Hal yang paling sering dikeluhkan pasien adalah sesak nafas dengan persentase 40,2%. Kesimpulan pada penelitian ini adalah pasien karsinoma paru terbanyak pada kelompok usia 46 sampai 55 tahun yang didominasi pasien yang berjenis kelamin laki-laki, dengan tipe terbanyak adalah adenocarcinoma dan sesak nafas adalah keluhan yang paling sering ditemukan. Kata Kunci: Karsinoma Paru, Karakteristik, Histopatologi.
KARAKTERISTIK PASIEN KARSINOMA PARU DI RSUP SANGLAH DENPASAR TAHUN 2017-2018 I Gusti Bagus Mulia Agung Pradnyaandara; Herman Saputra; I Gusti Ayu Sri Mahendra Dewi; I Wayan Juli Sumadi
E-Jurnal Medika Udayana Vol 9 No 11 (2020): Vol 9 No 11(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2020.V09.i11.P07

Abstract

ABSTRAKKarsinoma paru adalah keganasan dengan angka mortalitas tertinggi di dunia pada penduduk pria. Karsinoma paru dimulai dari munculnya tumor supressor gen pada genom(onkogen). Inisiator yang mengubah tumor suppressor gen dengan delesi maupun insersisebagian dari susunan pasangan basanya, adanya gen erbB1 dan atau erbB2 yang memilikiperan anti apoptosis. Sekitar delapan koma dua juta angka kematian pada tahun 2012diakibatkan oleh karsinoma. Tujuan penelitian ini untuk mengetahui karakteristik pasien yangmengalami karsinoma paru di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitiandeskriptif cross-sectional. Sampel terpilih adalah populasi yang telah melalui kriteria inklusimaupun eksklusi. Dengan perangkat lunak SPSS versi 22 data ini diolah. Hasil penelitianmenunjukkan kasus karsinoma paru tersering pada kelompok usia 46-55 tahun sebesar 31,5%dimana jenis kelamin laki-laki adalah yang terbanyak (61,4%). Sebagian besar pasienkarsinoma paru menderita tipe histopatologi dari adenocarcinoma (66,9%). Hal yang palingsering dikeluhkan pasien adalah sesak nafas dengan persentase 40,2%. Kesimpulan padapenelitian ini adalah pasien karsinoma paru terbanyak pada kelompok usia 46 sampai 55 tahunyang didominasi pasien yang berjenis kelamin laki-laki, dengan tipe terbanyak adalahadenocarcinoma dan sesak nafas adalah keluhan yang paling sering ditemukan. Kata Kunci: Karsinoma Paru, Karakteristik, Histopatologi.
Passive Smoking as a Significant Risk Factor of Cervical Dysplasia: A Novel Findings in Single Center Study in Denpasar, Bali, Indonesia Pradnyana, I Wayan Agus Surya; Mirani Ulfa Yusrika; I Gusti Bagus Mulia Agung Pradnyaandara; I Gde Sastra Winata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1126

Abstract

Background: Colposcopy is a diagnostic procedure evaluating the cervix following an abnormal screening test. It aims to identify and treat cervical cancer precursors. Risk stratification at the end of colposcopy helps differentiate those who can return to regular screening from those needing more frequent screening or surveillance. The study examined the characteristics and risk factors of patients undergoing colposcopy for cervical dysplasia in Denpasar, Bali, Indonesia. Methods: This was a cross-sectional study of women who underwent colposcopy at BaliMed Hospital, Denpasar, Bali, Indonesia, from January 2021-December 2022. Data were derived from medical records. The gynecology oncologist performed a colposcopy examination with a biopsy sample, which was later checked by the pathologist. Bivariate and multivariate analyses were used to identify the risk factors associated with cervical dysplasia. Results: 142 patients underwent colposcopy with a mean age of 37.28+10.1 years. Seventy-eight patients (54.9%) had a low-grade cervical lesion, and 9 (6.3%) had a high-grade cervical lesion. After adjusting the employment status and education level, factors associated with cervical dysplasia were age at first intercourse <20 years (aOR [adjusted odd ratio] 2.44, 95% CI [1.04-5.69]) and history of smoking, either actively or passively (aOR 8.91, 95% CI [3.52-22.54]). From the biopsy result, patients with abnormal cervical lesions were associated with evidence of CIN (aOR 9.03, 95% CI [2.49-32.77]). Conclusion: Early age first sexual intercourse and history of smoking have been identified as significant risk factors for cervical dysplasia. Additionally, passive smoking has been shown to increase the risk. This research provides a foundational reference for future studies in this area.
Passive Smoking as a Significant Risk Factor of Cervical Dysplasia: A Novel Findings in Single Center Study in Denpasar, Bali, Indonesia Pradnyana, I Wayan Agus Surya; Mirani Ulfa Yusrika; I Gusti Bagus Mulia Agung Pradnyaandara; I Gde Sastra Winata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1126

Abstract

Background: Colposcopy is a diagnostic procedure evaluating the cervix following an abnormal screening test. It aims to identify and treat cervical cancer precursors. Risk stratification at the end of colposcopy helps differentiate those who can return to regular screening from those needing more frequent screening or surveillance. The study examined the characteristics and risk factors of patients undergoing colposcopy for cervical dysplasia in Denpasar, Bali, Indonesia. Methods: This was a cross-sectional study of women who underwent colposcopy at BaliMed Hospital, Denpasar, Bali, Indonesia, from January 2021-December 2022. Data were derived from medical records. The gynecology oncologist performed a colposcopy examination with a biopsy sample, which was later checked by the pathologist. Bivariate and multivariate analyses were used to identify the risk factors associated with cervical dysplasia. Results: 142 patients underwent colposcopy with a mean age of 37.28+10.1 years. Seventy-eight patients (54.9%) had a low-grade cervical lesion, and 9 (6.3%) had a high-grade cervical lesion. After adjusting the employment status and education level, factors associated with cervical dysplasia were age at first intercourse <20 years (aOR [adjusted odd ratio] 2.44, 95% CI [1.04-5.69]) and history of smoking, either actively or passively (aOR 8.91, 95% CI [3.52-22.54]). From the biopsy result, patients with abnormal cervical lesions were associated with evidence of CIN (aOR 9.03, 95% CI [2.49-32.77]). Conclusion: Early age first sexual intercourse and history of smoking have been identified as significant risk factors for cervical dysplasia. Additionally, passive smoking has been shown to increase the risk. This research provides a foundational reference for future studies in this area.
Co-Authors Herman Saputra I Gde Sastra Winata I Gusti Ayu Sri Mahendra Dewi I Wayan Juli Sumadi Mirani Ulfa Yusrika Pradnyana, I Wayan Agus Surya