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All Journal E-Jurnal Medika Udayana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Ni Nyoman Mahartini
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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GAMBARAN KARAKTERISTIK PASIEN ACUTE MYELOID LEUKEMIA DI RSUP SANGLAH DENPASAR TAHUN 2018 I Made Bagus Cahya Wibawa; A. A. Ngurah Subawa; I Wayan Putu Sutirta Yasa; Ni Nyoman Mahartini
E-Jurnal Medika Udayana Vol 10 No 6 (2021): Vol 10 No 06(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i6.P08

Abstract

Acute Myeloid Leukemia (AML) merupakan salah satu keganasan hematologi dengan jumlah penderita terbanyak di dunia. Insiden AML meningkat setiap tahunnya secara global. Penelitian ini bertujuan mengetahui karakteristik pasien AML di Bagian Penyakit Dalam RSUP Sanglah Denpasar tahun 2018. Penelitian dilakukan dengan metode deskriptif menggunakan studi potong lintang. Penelitian dilaksanakan pada bulan Maret - September 2019. Sampel penelitian ini sebanyak 34 rekam medik pasien AML yang dirawat inap di RSUP Sanglah tahun 2018. Data dianalisis menggunakan perangkat lunak Microsoft Excel untuk mendapatkan karakteristik pasien AML berdasarkan usia, keluhan utama, jenis kelamin, kadar hemoglobin, jumlah leukosit, jumlah trombosit, persentase blast, dan diagnosis berdasarkan FAB. Hasil penelitian menunjukkan frekuensi tertinggi pasien AML diperoleh pada kelompok usia 41-60 tahun (35,29%) dan didominasi jenis kelamin laki-laki (58,82%). Keluhan utama tersering yang dialami adalah badan lemah (55,88%). Berdasarkan hasil pemeriksaan darah lengkap, kebanyakan pasien AML ditemukan mengalami anemia sedang dengan kadar hemoglobin 8-10 g/dL (58,82%), jumlah leukosit >50.000/mm3 atau hiperleukositosis (47,06%), dan trombositopenia grade IV dengan jumlah trombosit <25.000/mm3 (38,24%). Berdasarkan pemeriksaan sumsum tulang, frekuensi terbanyak ditemukan pada pasien AML dengan persentase sel blast 30-39% (38,24%) dan tipe AML M4 atau Acute Myelomonocytic Leukemia (44,12%). Hasil penelitian ini berguna untuk penelitian lanjutan karena dapat memberi gambaran tentang karakteristik pasien AML di RSUP Sanglah Bali tahun 2018. Perlu dilaksanakan penelitian lebih lanjut untuk mengetahui hubungan antar variabel. Kata Kunci: Acute Myeloid Leukemia, Gambaran Karakteristik
Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Co-Authors Anak Agung Ngurah Subawa Desak Laksmi I Made Bagus Cahya Wibawa I Made Kardana I Nyoman Wande I Wayan Putu Sutirta Yasa Ni Kadek Mulyantari Sianny Herawati