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All Journal E-Jurnal Medika Udayana Open Access Indonesian Journal of Medical Reviews
Dewa Ayu Agung Maya Gayatri
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Health Professions Medicine & Pharmacology

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UJI EFEKTIVITAS EKSTRAK ETANOL DAUN BELUNTAS (Pluchea IndicaL.) TERHADAP PERTUMBUHAN BAKTERI Streptococcus Pyogenes ATCC 19615 SECARA IN VITRO Dewa Ayu Agung Maya Gayatri; Desak Ketut Ernawati; Ida Ayu Alit Widhiartini
E-Jurnal Medika Udayana Vol 10 No 1 (2021): Vol 10 No 01(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/.MU.2021.V10.i1.P02

Abstract

Daun beluntas(Plucheaindica L.) dinyatakan mengandung metabolit sekunder yang efektif sebagai antiinfeksi. Penyakit infeksi yang disebabkan oleh bakteri Streptococcuspyogenes berdampak serius terhadap perkembangan penyakit faringitisakut hingga endocarditis yang mengancam jiwa. Penelitian ini ditunjukkan untuk membuktikan efektivitas ekstraketanol daun beluntas sebagai antibakteri terhadap S.pyogenes. Uji efektivitas antibakteri ekstraketanol daun beluntas pada konsentrasi 25%,50%,dan75%, dengan kontrol positif Amoksisilin 30µg serta kontrolnegatif etanol96% yang dilakukan terhadap bakteri S.pyogenesATCC 19615 dengan metode cakram disk. Uji fitokimia dilakukan untuk membuktikan adanya kelompok senyawa aktifpada ekstrakuji. Diameterzona hambatdiukur pada hari kedua setelah inkubasibakteri. Diameterzona hambat yangterbentuk pada kelompok konsentrasi 25%,50%,dan75%, secara berurutan adalah 8 mm, 10,5 mm, dan 17,5 mm. Untuk mengetahui adanya efekperlakuan, dilakukan analisis terhadap UjiKruskal-Wallis didapatkan nilaip=0,0001, dan untuk mengetahui adanyakorelasi peningkatan dosisterhadap peningkatan efek antibakteri dilakukan Uji Independent SamplesTest dan Mann Whitney.Ekstraketanol daun beluntas (Plucheaindica L.)memiliki daya hambat pada kadar 25%,50%, dan75% terhadap pertumbuhan bakteri Streptococcus pyogenes ATCC 19615. Kata kunci : Daun Beluntas, ZonaHambat Bakteri, Streptococcus pyogenes
Long-Term Comparative Effectiveness of Transcatheter Aortic Valve Replacement (TAVR) Versus Surgical Aortic Valve Replacement (SAVR) in High-Risk Aortic Stenosis Patients: A Meta-Analysis Senthanu, I Gede Andrika Indrayoga; Dewa Ayu Agung Maya Gayatri
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 3 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i3.600

Abstract

Transcatheter aortic valve replacement (TAVR) has become an alternative to surgical aortic valve replacement (SAVR) for high-risk patients with severe aortic stenosis (AS). This meta-analysis aims to compare the long-term outcomes of TAVR and SAVR in this population. A systematic search of PubMed, Embase, and the Cochrane Library was conducted up to December 2023. Randomized controlled trials (RCTs) and observational studies comparing TAVR and SAVR with a minimum follow-up of one year were included. The primary outcome was all-cause mortality. Secondary outcomes included cardiovascular mortality, stroke, myocardial infarction (MI), and rehospitalization. Twenty-three studies involving 15,482 patients (TAVR=7,785, SAVR=7,697) were included. The mean follow-up period was 3.2 years (range 1-5 years). There was no significant difference in all-cause mortality between TAVR and SAVR (Hazard Ratio [HR] 1.02, 95% CI 0.95-1.09, p=0.63). Similarly, there were no differences in cardiovascular mortality (HR 1.05, 95% CI 0.96-1.15, p=0.28), stroke (HR 0.98, 95% CI 0.87-1.10, p=0.75), or MI (HR 0.94, 95% CI 0.82-1.08, p=0.39). However, TAVR was associated with a lower rate of rehospitalization (HR 0.85, 95% CI 0.78-0.93, p=0.001). TAVR is a viable alternative to SAVR in high-risk patients with AS, demonstrating comparable long-term survival and safety outcomes. The reduced rehospitalization rate associated with TAVR may be an important consideration for these patients.
Co-Authors Desak Ketut Ernawati I.A.A. Widhiartini Senthanu, I Gede Andrika Indrayoga