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KARAKTERISTIK PENDERITA LEUKEMIA AKUT YANG DIRAWAT DI RSUP SANGLAH DENPASAR TAHUN 2014-2015 Nyoman Ananda Putri Prashanti; Ni Made Renny Anggreni Rena
E-Jurnal Medika Udayana Vol 9 No 4 (2020): Vol 9 No 04(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.362 KB) | DOI: 10.24843/MU.2020.V09.i4.P01

Abstract

Minimnya data atau informasi mengenai studi deskriptif epidemiologi di Indonesia, membuat penelitian mengenai karakteristik penderita leukemia akut, Leukemia Limfoblastik Akut (LLA) dan Leukemia Mieloblastik Akut (LMA), menjadi penting. Penelitian ini dilakukan untuk mengetahui gambaran profil pasien di Rumah Sakit Umum Pusat Sanglah Denpasar secara lokal, dan mendapatkan data mengenai sosiodemografi, profil klinis, parameter hematologi, profil histopatologi, dan penatalaksanaan pasien leukemia akut. Penelitian ini merupakan penelitian deskriptif retrospektif, yang dilaksanakan pada bulan Februari 2016 sampai dengan September 2016. Teknik pengumpulan sampel adalah dengan total sampling. Didapatkan jumlah sampel sebesar 41 orang, 11 orang LLA, dan 30 orang LMA, dengan rerata usia LLA: 17±6,65 tahun dan LMA: 48±14,88 tahun. Baik LLA dan LMA memiliki keluhan utama terbanyak, yaitu lemas (LLA: 66,7% dan LMA: 41,7%), dan hasil pemeriksaan fisik terbanyak adalah anemia (LLA: 100% dan LMA: 77,8%). Rerata jumlah leukosit pada penderita LLA adalah (94,95±186,87) X 103/µL, sedangkan pada LMA adalah (63,97±75,61) X 103/µL. Rerata kadar hemoglobin (HB) pada penderita LLA dan LMA berturut-turut adalah 7,35±2,82 gr/dL dan 8,24±2,89 gr/dL. Sedangkan rerata jumlah platelet adalah (57,81±45,28) X 103/µL dan (43,27±81,66) X 103/µL. LLA-L2 merupakan klasifikasi terbanyak pada penderita LLA, sedangkan untuk LMA adalah LMA-M4. Rerata lama rawatan penderita LLA dan LMA berturut-turut adalah 13 dan 15 hari. Terdapat 8 penderita LMA yang meninggal selama perawatan, dan syok sepsis (37,5%) merupakan penyebab kematian tertinggi. Kata kunci: Karakteristik, Leukemia Limfoblastik Akut, Leukemia Mieloblastik Akut, Sanglah
Surfactant Therapy in Meconium Aspiration Syndrome: A Case Report Dyatmika Tanaya, Putu Wahyu; Ida Ayu Sri Kusuma Dewi; Nyoman Ananda Putri Prashanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.950

Abstract

Background: Meconium aspiration syndrome (MAS) is one of many causes of respiratory distress in newborns. Data regarding MAS in Indonesia is still very limited, but a study revealed MAS is related to a high mortality rate. The latest study revealed surfactant therapy is related to better clinical outcomes in MAS cases. This study aimed to present a case of a baby with meconium aspiration syndrome given bolus surfactant therapy. Case presentation: A day-old baby was referred to our emergency department with respiratory distress, delivered by cito caesarean section due to cephalopelvic disproportion with premature rupture of membranes. The baby didn’t cry immediately; bluish skin and green amniotic fluid were found. The baby was already intubated from the referring hospital, and the physical examination revealed rales on both lungs with severe work of breath. Chest radiography revealed patchy opacities in the right lung hemisphere, suggesting MAS. Echocardiography revealed a small patent ductus arteriosus, and head ultrasonography revealed mild brain oedema. The baby received bolus bovine surfactant therapy at 16 hours of age, delivered through an endotracheal tube. Clinical improvement was observed, and supplementary oxygen was reduced gradually. The baby was able to maintain good oxygenation without supplemental oxygen by day 12th and was able to breastfeed and drink from the bottle. He was discharged with good condition. Conclusion: Surfactant therapy can become a safe and effective treatment modality in MAS. Further study is still needed regarding time, method, and types of surfactants used in MAS management.
Surfactant Therapy in Meconium Aspiration Syndrome: A Case Report Dyatmika Tanaya, Putu Wahyu; Ida Ayu Sri Kusuma Dewi; Nyoman Ananda Putri Prashanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.950

Abstract

Background: Meconium aspiration syndrome (MAS) is one of many causes of respiratory distress in newborns. Data regarding MAS in Indonesia is still very limited, but a study revealed MAS is related to a high mortality rate. The latest study revealed surfactant therapy is related to better clinical outcomes in MAS cases. This study aimed to present a case of a baby with meconium aspiration syndrome given bolus surfactant therapy. Case presentation: A day-old baby was referred to our emergency department with respiratory distress, delivered by cito caesarean section due to cephalopelvic disproportion with premature rupture of membranes. The baby didn’t cry immediately; bluish skin and green amniotic fluid were found. The baby was already intubated from the referring hospital, and the physical examination revealed rales on both lungs with severe work of breath. Chest radiography revealed patchy opacities in the right lung hemisphere, suggesting MAS. Echocardiography revealed a small patent ductus arteriosus, and head ultrasonography revealed mild brain oedema. The baby received bolus bovine surfactant therapy at 16 hours of age, delivered through an endotracheal tube. Clinical improvement was observed, and supplementary oxygen was reduced gradually. The baby was able to maintain good oxygenation without supplemental oxygen by day 12th and was able to breastfeed and drink from the bottle. He was discharged with good condition. Conclusion: Surfactant therapy can become a safe and effective treatment modality in MAS. Further study is still needed regarding time, method, and types of surfactants used in MAS management.