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All Journal Jurnal Veteriner Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education
Yuni Susanti Pratiwi
Fakultas Kedokteran Universitas Padjadjaran
Health Professions Medicine & Pharmacology Public Health Veterinary

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Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.585 KB)

Abstract

Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.
THE RELATIONSHIP BETWEEN TYPES OF ADMISSION SELECTION AND ACADEMIC ACHIEVEMENT IN THE FIRST-YEAR STUDENTS DURING THE TRANSITION TO DISTANCE LEARNING DUE TO COVID-19 PANDEMIC Nikla Sekar Salsabila; Kurnia Wahyudi; Yuni Susanti Pratiwi; Eko Fuji Ariyanto; Achadiyani Achadiyani
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 11, No 1 (2022): Maret
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.64464

Abstract

Background: In 2019, there were three admission pathways in the Faculty of Medicine Universitas Padjadjaran (FMUP), which were SNMPTN (Seleksi Nasional Masuk Perguruan Tinggi Negeri), SBMPTN (Seleksi Bersama Masuk Perguruan Tinggi Negeri), and Seleksi Mandiri Universitas Padjadjaran (SMUP). SNMPTN was based on previous academic achievements in senior high school. SBMPTN was held through a highly competitive national examination, while SMUP was conducted through the test held by Universitas Padjadjaran. In their first year, batch 2019 students had to adapt to college life, and also to the transition into distance learning due to the COVID-19 pandemic. This study aimed to know whether types of student admission selection contribute to academic achievements of the first-year students in the Hemato-immunology system (HIS), where the learning process was held during the transition into distance learning.Methods: This study compared the academic achievement of first-year students (batch 2019) on the second semester’s second half, using their HIS Multidisciplinary Examination (MDE) scores, for three selection methods. The data were 256 MDE scores of those students. Statistical analysis was performed using One Way ANOVA test, followed by Post-hoc Tukey test.Results: There was a statistically significant difference of HIS MDE scores for each selection method. The highest mean was by SNMPTN group (68.29+10.44), followed by SBMPTN group (64.90+11.29) and SMUP group (63.25+9.95).Conclusion: Students of SNMPTN group, who were selected based on previous academic achievements in senior high school, had higher HIS MDE scores than the other groups. 
Co-Authors Achadiyani Arto Yuwono Soeroto Eko Fuji Ariyanto Fani Rahma Yenita Hanna Goenawan Iwan Setiawan Kurnia Wahyudi Nikla Sekar Salsabila Nova Sylviana Prayudi Santoso Ronny Lesmana Unang Supratman Vita Murniati Tarawan