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Knowledge and Attitude on Febrile Seizure among Mothers with Under-Five Children Syahida, Jihan Alifa; Risan, Nelly Amalia; Tarawan, Vita Murniati
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.238 KB)

Background: Febrile seizures frequently occur in children under 5 years old and usually create fear and anxiety among parents. Poor understanding of febrile seizure among parents contributes to mismanagement of seizure. The objective of this study was to identify the knowledge and attitude on febrile seizure among mothers of under five children.Methods: This descriptive community-based survey comprised of 96 mothers with under 5 children who were chosen through randomization. This survey was, conducted in Hegarmanah Village, Jatinangor, West Java, Indonesia in October 2013. Data were collected using a questionnaire and analyzed using frequency analysis.Results: Fifty nine respondents (61%) considered that high fever in their children will result in seizure and 63 mothers (65%) stated that this condition was a life-threatening situation which could lead to brain damage (50%) and paralysis (50%). There were some respondents who would manage seizure by shaking (27%) or holding the child tightly during seizure (22%) and putting spoon into the children mouth (59%). Sixty respondents (62.5%) prevented febrile seizure by giving them coffee.Conclusions: Knowledge and attitude regarding febrile seizure is good, but the knowledge and attitude towards the outcome and what to do during febrile seizures occasion are still poor. [AMJ.2016;3(4):649â54]Â DOI:Â 10.15850/amj.v3n4.954

Effects of Ageratum conyzoides Leaf Decoction on Glucose Absorption in Rat’s Small Intestine Sakinah, Siti; Dhianawaty, Diah; Tarawan, Vita Murniati
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Althea Medical Journal

Background: Obesity is one of the health problems caused by excessive glucose intake which exceeds normal body requirement. To prevent health problems, Indonesian natives used traditional herbs, such as Ageratum conyzoides (billygoat weeds). The study aimed to discover the effect of Ageratum conyzoides leaf decoction on glucose absorption in the small intestine of rats.Methods: An experimental study was conducted at the Biochemical Laboratory of Faculty of Medicine, Universitas Padjadjaran. Two groups of six rats were given Ageratum conyzoides leaf decoction with dosages 0.89 and 1.33 g/kgbw respectively. Each rat was given glucose solution as a control, decoction administration along with the glucose solution, and glucose solution again to discover the effect of decoction in the absorption function after the administration of decoction was discontinued. Glucose absorbed by the intestine was measured every 15 minutes in 1 hour after the administrationof the solution.Results: Glucose absorption was impeded in dosage 1 and 2 with a mean of the gap between glucose absorbed concentration before given decoction and after given decoction were 73.97 and 45.09 mg/dl respectively. Analysis using paired t-test resulted in insignificant meaning (p-value of dosage 0.89 g/kgbw=0.08; p-value of dosage 1.33 g/kgbw=0.06). In the last glucose perfusion, absorption increased in both dosages after administration of decoction was discontinued.Conclusions: Ageratum conyzoides leaf decoctioncan inhibit the glucose absorption in the small intestine but is not statistically significant. Further investigation may be needed by using a higher concentration of Ageratum conyzoides and/or other filtration methods.

Exercise Serum Alters Genes Related Mitochondria in Cardiomyocyte Culture Cell Lesmana, Ronny; Prasetyo, Wibowo Budi; Ray, Hamidie Ronald Daniel; Tarawan, Vita Murniati; Goenawan, Hanna; Setiawan, Iwan; Pratiwi, Yuni Susanti; Juliati, Nova Sylviana; Supratman, Unang
JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Vol 5, No 2 (2020): Improving Physical Education to Promote Healthy Growth
Publisher : Universitas Pendidikan Indonesia

Exercise-induced hearth muscle adaptation is important for physiological process after exercise. This adaptation will ensure basal mitochondrial homeostasis and as a part of the mitochondria quality control. This process is reflected by equal level of biogenesis stimulation and as well as the selective degradation of old and undesirable mitochondria through fusion or fission cycle and Mitophagy. There is limited information about genetic regulation stimulated by training in cardiomyocytes. We believe there is a specific myokines or protein release in the serum and initiate cardiac muscle adaptation process. In the present study, twelve male wistar rats were appointed to two group: sedentary control and aerobic-intensity (AE, 15m/minute). Rats were trained for running with specific protocol as follows: 30 minutes/day with a 5 times/week interval for 8 weeks. On the last day, serum form control and exercise groups were taken via retro-orbital sinus. Then, 3.105Â H9C2 cells (Rat cardiomyocytes cell line)Â were cultured and incubated by this serum for 24 hours. After treatment, cell were extracted using trisure for RNA purification and continue with reverse transcriptase PCR. Our data showed that expression of the Pgc-1Î±, Mfn1, Mfn2, Opa1, Drp1, Pink, and Parkin genes were altered and modulated. Specifically, Mfn1, Mfn2, and Opa1 gene expression levels significantly increased. Interestingly, we did not find significant modulation forÂ Pgc-1Î±, Drp1, Pink, and Parkin. Taken together, serum of exercise rats might be contained with myokines or specific protein which was released during training and it altered mitochondrial genes expression in cardiomyocytes culture cell. We believe that myokines release in the serum had a contribution in cardiacmyocyte adaptation.

Effects of Moringa Leaf Extract and Moderate Intensity Exercise on Histopathological Appearance and Autophagy Gene Expression Gunadi, Julia Windi; Jatnika, Danti Dja; Astrid, Stephanie; Lucretia, Teresa; Ray, Hamidie Ronald Daniel; Goenawan, Hanna; Tarawan, Vita Murniati; Nurhayati, Titing; Lesmana, Ronny
JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Vol 6, No 1 (2021): Opportunities from The Sport and Health Education to Improve Quality of Life
Publisher : Universitas Pendidikan Indonesia

The prevention of liver disease could be conducted through preventive strategies, such as antioxidants and exercise. Moringa leaf extract has substances that could act as antioxidant, while exercise is also known protecting the liver from disease by changing hepatic metabolism and autophagy. This study aimed to investigate the effect of moringa leaf extract and moderate intensity exercise on histopathological appearance and autophagy gene expression of wistar rat liver. The method used in this study was animal experiment using 24 male wistar rats divided into 4 groups, including control group, moringa group, exercise group, and moringa + exercise group. Moringa leaf extract was given in low dose (5.7 mg/kgW) per oral, 5 times a week, for 4 weeks. Meanwhile, the 20 m/minute treadmill exercise was given for 30 minutes per day, 5 times a week, for 4 weeks. Results showed a significant change on histopathological scoring in exercise group (p=0.011) compared to control group. Increased autophagy gene expression was found in moringa + exercise group compared to control group (LC3 0.90 fold; p62 0.87 fold). In summary, this study presented that moderate intensity exercise induced changes on histopathological appearance of wistar rat liver that might be associated with physiological inflammation. Moringa, with its antioxidant properties, combined with increased autophagy might improve histopathological changes in moringa + exercise group.

Forced Expiratory Volume in 1 Second and Forced Vital Capacity in Bronchial Asthma Patients in Relation with Asthma Exercise Atika Andianti; Vita Murniati Tarawan; Hendarsyah Suryadinata
Althea Medical Journal Vol 7, No 2 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n2.1781

Background: Aerobic physical activity is one of the non-pharmacology management approaches of asthma. The Asthma Foundation of Indonesia (Yayasan Asma Indonesia, YAI) has designed an aerobic physical activity for people with asthma, known as Asthma Exercise. Asthma exercise is expected to increase the overall functional capacity of the lungs. One way to measure lung function is by measuring the score of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). The objective of the study was to explore the difference in FEV1 and FVC between bronchial asthma patients with and without asthma exercise. Methods: This study involved asthma patients from the Bandung Asthma Association (Perhimpunan Asma Bandung, PAB) who did asthma exercise (n=28), and as control patients from the Pulmonology Clinic in Dr. Hasan Sadikin General Hospital were selected who did not do asthma exercise. The research data used were primary data from the spirogram examination. Asthma patients were selected based on inclusion and exclusion criteria. This research used unpaired numerical comparative analytical hypothetical tests with a cross-sectional design.Results: The study showed the mean of FEV1 and FVC in the group with asthma exercise (1.6107±0.3780L and 2.0396±0.3465L) was higher than the group without asthma exercise (1.3750±0.4702L and 1.7164±0.4632L). Statistical difference test using independent t-test indicated a score of p=0.044 for FEV1 and p=0.005 for FVC between the two groups.Conclusions: There are significant differences in FEV1 and FVC between bronchial asthma patients with and without asthma exercise. Furthermore, asthma exercise is recommended for asthma patients to improve their lung function.

Effects of Ageratum conyzoides Leaf Decoction on Glucose Absorption in Rat’s Small Intestine Siti Sakinah; Diah Dhianawaty; Vita Murniati Tarawan
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Obesity is one of the health problems caused by excessive glucose intake which exceeds normal body requirement. To prevent health problems, Indonesian natives used traditional herbs, such as Ageratum conyzoides (billygoat weeds). The study aimed to discover the effect of Ageratum conyzoides leaf decoction on glucose absorption in the small intestine of rats.Methods: An experimental study was conducted at the Biochemical Laboratory of Faculty of Medicine, Universitas Padjadjaran. Two groups of six rats were given Ageratum conyzoides leaf decoction with dosages 0.89 and 1.33 g/kgbw respectively. Each rat was given glucose solution as a control, decoction administration along with the glucose solution, and glucose solution again to discover the effect of decoction in the absorption function after the administration of decoction was discontinued. Glucose absorbed by the intestine was measured every 15 minutes in 1 hour after the administrationof the solution.Results: Glucose absorption was impeded in dosage 1 and 2 with a mean of the gap between glucose absorbed concentration before given decoction and after given decoction were 73.97 and 45.09 mg/dl respectively. Analysis using paired t-test resulted in insignificant meaning (p-value of dosage 0.89 g/kgbw=0.08; p-value of dosage 1.33 g/kgbw=0.06). In the last glucose perfusion, absorption increased in both dosages after administration of decoction was discontinued.Conclusions: Ageratum conyzoides leaf decoctioncan inhibit the glucose absorption in the small intestine but is not statistically significant. Further investigation may be needed by using a higher concentration of Ageratum conyzoides and/or other filtration methods.

Efek Suplementasi Selenium terhadap Marker Darah Pasca Cedera Kontusio Mariel Daba; Hanna Goenawan; Vita Murniati Tarawan; Aziis Mardanarian Rosdianto; Ronny Lesmana
Jurnal Kesehatan Andalas Vol 10, No 2 (2021): Online July 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1787

Selenium is a trace element that has antioxidant properties and is a component of selenoproteins. In certain circumstances, such as injury, selenium supplementation is required to regulate the inflammatory response. Contusion injury increases the inflammatory response to a muscle or tissue that begins with vasodilation, increases blood flow, increases vascular permeability, and leads to edema formation at the site of injury. Objectives: To determine the effect of selenium supplementation on changes in blood markers in rats treated with contusion injury. Methods: Experimental design, using experimental male rats (Rattus norwegius), eight weeks old, weighing 200-220 grams, divided into three groups, namely: The Control group, the contusion group, the contusion + Selenium group. Selenium supplementation was given orally on days 1-3 after injury at a dose of 0.0153 mg into 2% PGA. Examination of markers such as White Blood cells (WBC), lymphocytes, monocytes, and neutrophils was carried out on day three after treatment. Results: This study found that the administration of post-muscular selenium supplementation based on examination of blood markers such as WBC, Lymphocytes, Monocytes was higher in the contusion group and lower in the selenium group. Neutrophils were higher in the contusion and selenium groups. This was not significantly different from the control group. The result of blood marker examination tended to change, but it was not statistically significant. Conclusion: Selenium supplementation in post-contusive injury mice did not provide significant changes in blood markers such as WBC, lymphocytes, monocytes, and neutrophils.Keywords: antioxidant, blood marker, contusion, selenium

Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.585 KB)

Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.

Effect of Specific Formulated Feed to Alter the Glucose, Triglycerides and Total Cholesterol Level in Rat (EFEK FORMULASI PAKAN TIKUS TERHADAP PERUBAHAN KADAR GLUKOSA, TRIGLISERIDA DAN KOLESTEROL TOTAL) Jihan Mudrika Rahmi; Ronny Lesmana; Hana Goenawan; Setiawan Setiawan; Vita Murniati Tarawan; Okta Wismandanu; Unang Supratman
Jurnal Veteriner Vol 20 No 2 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Understanding the molecular mechanism of type 2 diabetes mellitus using human sample is very difficult, therefore utilization of animal model can be the solution for studying diabetes mellitus. However, there is still limited option of the animal model that can describe the process of type 2 diabetes mellitus. The aim of this study is to develop a formulated feed with increased glucose, triglycerides, and total cholesterol as characteristics of type 2 diabetes mellitus. This study was done using a descriptive method and experimental study design for 8 weeks. Total 9 male and 12 female Wistar rats were randomly divided into 3 groups: 1 control group and 2 treatment group (formula 1: high carbohydrate, formula 2: high fat). The increase of delta mean body weight was higher in the group given formula 1 for both male and female rats (f: 52g, m: 71.67g). The glucose level was increase from 4th- 8th week in both gender of rats and higher in the group given formula 1 of female rats (4W: 221.13 mg/dl; 8W: 249.83 mg/dl). The triglycerides level was increased from 4th to 8th week and higher in group given formula 2 either male (4W: 37.42 mg/dl; 8W: 58.92 mg/dl) but not in female rats (4W: 76.78 mg/dl; 8W: 71.22 mg/dl). The cholesterol total level also increased in male (4W: 93.05 mg/dl; 8W: 282.5 mg/dl) and female (4W: 101.58 mg/dl; 8W: 227.17 mg/dl) rats and higher in the group given formula 1. In conclussio, either high carbohydrate or high fat pellet showed potential capability to increase the glucose, triglyceride and total cholesterol level especially in female rats.

Knowledge Improvement on Burn Injury Prevention and First Management after One-Day Health Promotion Event Lisa Hasibuan; Hardisiswo Soedjana; Dany Hilmanto; Vita Murniati Tarawan; Benny Muliawan; Putra Haqiqie Adnantama Lubis
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Burns causes a significant number of mortality and morbidity globally with a higher number found in developing countries, such as Indonesia. A study conducted in Indonesia discovered that the majority of burns were caused by flame LPG-related (liquefied petroleum gas) burns (33%), which is understandable because LPG is the main cooking fuel used in Indonesian homes. Since the first management of burn will influence the outcome of burn injuries, health promotion efforts to improve knowledge, attitude, and practice to prevent burns and to provide first aid for burn are considered important to reduce burn-related morbidity and mortality. This was a descriptive study conducted in Babakan Sari Sub-district, Antapani, Bandung, Indonesia which involved a one-day community health promotion event as the intervention. The aim of this study was to compare the level of knowledge regarding burn prevention and first management before and after a one-day community health promotion event. As many as 61 respondents were recruited through purposive sampling and these respondents were asked to fill out a pre-event questionnaire consisting of questions regarding demographic data and knowledge on burn prevention and management. Demographic data collected showed that 31% of participants had experienced burns; 100% of participants used 3kg LPG gas tank in their home; 98% of participants had never been taught on how to handle an emergency situation or how to arrange an evacuation route; and 100% of participants felt that their neighborhood did not provide facilities for burn management. A post-event questionnaire was distributed after the one-day health promotion event, which was conducted in October 2018, and the results were compared with the pre-event questionnaire results. A significant improvement of knowledge was seen, as evident from the increase of a median score from 2.0 before the event to 9.0 after the event (p<0.001). In conclusion, despite the fact that all participants of this study used 3kg LPG gas tank, they do not have proper knowledge regarding prevention or management of burns and that a one-day health promotion event can increase this knowledge significantly. Thus, an effective community health promotion program should be implemented at the community level in Indonesia, especially for areas where the majority of residents use 3 kg LPG gas tank, in order to reduce the incidence of burns due to 3 kg LPG tank explosion.Peningkatan Pengetahuan Melalui Penyuluhan Mengenai Pencegahan dan Penanganan Dini pada Luka BakarLuka bakar merupakan sebuah masalah yang menyebabkan morbiditas dan mortalitas tinggi di negara berkembang, termasuk Indonesia. Mayoritas luka bakar (33%) diakibatkan oleh api dari ledakan tabung gas LPG (liquefied petroleum gas) 3 kg dan mayoritas rumah tangga menggunakannya. Pelaksanaan penyuluhan mengenai pencegahan dan penanganan awal diharapkan dapat menurunkan angka morbiditas dan mortalitas akibat luka bakar. Penelitian deskriptif ini bertujuan membandingkan tingkat pengetahuan tentang pencegahan luka bakar dan manajemen pertama sebelum dan setelah acara promosi kesehatan Penelitian ini dilakukan di Kelurahan/Desa Babakan Sari, Antapani, Bandung pada bulan Oktober 2018 untuk mengedukasi dan meningkatkan pengetahuan responden. Dari total 61 responden (45 wanita dan 16 pria) dengan mayoritas responden berusia di atas 60 tahun (45.9%), didapatkan 32.8% responden pernah mengalami luka bakar, 100% responden menggunakan gas LPG 3 kg, 98% peserta tidak pernah mendapatkan penyuluhan mengenai penanganan luka bakar, dan 100% peserta merasa tidak ada fasilitas penanganan kebakaran di wilayah mereka. Pengetahuan responden dinilai sebelum dan sesudah dilakukan penyuluhan dan didapatkan peningkatan secara signifikan dan bermakna (p<0.001). Simpulan, meskipun semua responden yang menggunakan tangki gas LPG 3 kg tidak memiliki pengetahuan yang memadai pencegahan atau pengelolaan luka bakar, penyuluhan ini efektif dapat menurunkan angka kejadian luka bakar.

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