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All Journal Medical Journal of Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kedokteran Hewan
Peter Kabo
National Cardiac Centers, Rumah Sakit Jantung Harapan Kita and Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta.
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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 1 
The inotropic effect of isoniazid on isolated atria of guinea-pigs Kabo, Peter
Medical Journal of Indonesia Vol 9, No 1 (2000): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.289 KB) | DOI: 10.13181/mji.v9i1.645

Abstract

[no abstract available]
Atropine-resistant atrioventricular block in non-Q-wave myocardial infarction: The role of low dose aminophylline (case report) Kabo, Peter; Hanafiah, Asikin
Medical Journal of Indonesia Vol 3, No 4 (1994): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.601 KB) | DOI: 10.13181/mji.v3i4.979

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[no abstract available]
Isometric exercise, cold pressure test, and valsalva maneuver in subjects with essential hypertension and normal blood pressure Kabo, Peter
Medical Journal of Indonesia Vol 4, No 2 (1995): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (831.408 KB) | DOI: 10.13181/mji.v4i2.902

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[no abstract available]
Nefroprotective Effect of Gynura procumbens Extract Against Paracetamol Toxicity in Rats Ishak, Pertiwi; Kabo, Peter; Yusrini Djabir, Yulia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15584

Abstract

ABSTRACT Excessive doses of paracetamol have the potential to cause acute kidney injury and even death. Gynura procumbens has been traditionally used as folk-medicine for kidney disease. This study aimed to examine the nephroprotective effect of Gynura procumbens leaf extract against paracetamol-induced nephrotoxicity in rats. Twenty-five male wistar rats (150-200 g) were divided into 5 groups. Healthy control group, placebo group, and 3 extract treatment groups that received either 100 mg/kg, 200 mg/kg or 300 mg/kg dose. The placebo (sodium carboxymethyl cellulose) or extract was given 4 consecutive days prior to paracetamol (2400 mg/kg) administration on day 5. Blood samples were withdrawn before treatment initiated (day 0), after treatment before paracetamol administration (day 5) and 24-hour after paracetamol administration (day 6). Blood samples were analyzed to obtain urea and creatinine levels. In addition, histopathological analysis was performed on the renal tissue. Paracetamol administration was shown to significantly increase the urea and creatinine levels, and the extract at 300 mg/kg dose was able to significantly prevent the elevation of the renal biomarkers. The histopathological analysis also revealed a significant reduction in renal histopathological injury in 300 mg/kg extract group. It can be concluded that the ethanolic extract of the Gynura procumbens at a dose of 300 mg/kg has a good protective effect on kidney function and tissue structure. Key words: Gynura procumbens, nephroprotective, paracetamol
SUBACUTE TOXICITY TEST OF BEACH CABBAGE [Scaevola taccada (Gaertn.) Roxb.] LEAF EXTRACT ON HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEYS OF WHITE RATS Widati, Aritzah Dwi; Adri, Tenri Ayu; Kabo, Peter; Djabir, Yulia Yusrini
Jurnal Kedokteran Hewan Vol 16, No 2 (2022): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i2.19310

Abstract

The purpose of this study was to evaluate the toxic effects of beach cabbage leaves [Scaevola taccada (Gaertn.) Roxb.]by observing the histopathological changes in the livers and kidneys of male white rats. This study used 20 white rats which were divided into 4 groups: 1 control group and 3 groups receiving treatments in the form of Scaevola taccada leaf ethanolic extract (STLEE) in graded doses (200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW). Toxicity test was performed by administering STLEE for 14 days. The results of daily observations showed that the experimental animals experienced diarrhea. Meanwhile, histopathological observations showed the occurrences of hydropic degeneration, fat degeneration, necrotic liver cells, and dilatation of Bowman's capsule in the animals kidney cells. It was concluded that STLEE at a dose of 200 mg/kg BW is safe to use, but is toxic at a dose of 600 mg/kg BW, both to the livers and kidneys.
Co-Authors Adri, Tenri Ayu Asikin Hanafiah Djabir, Yulia Yusrini Ishak, Pertiwi Widati, Aritzah Dwi Yusrini Djabir, Yulia