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All Journal Jurnal Kesehatan Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Jurnal Kedokteran Hewan
Djabir, Yulia Yusrini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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ACE2 EXPRESSION OF HYPERTENSIVE RAT LUNGS GIVEN ACE-I, CCB, AND SWITCHING ACEI TO CCB Abustani, Muthiah; Arsyad, Aryadi; Idris, Irfan; Djabir, Yulia Yusrini; Djaharuddin, Irawaty; Kasim, Hasim; Ismail, Amirah Febrianti
Jurnal Kesehatan Vol 17 No 2 (2024): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v17i2.38444

Abstract

Latar belakang : Hipertensi merupakan komorbid terbanyak pada COVID-19 dan ACE2 sebagai reseptor yang akan berikatan dengan virus SARS-COV-2, juga berperan dalam regulasi tekanan darah. Penggunaan obat antihipertensi seperti ACE-I atau CCB dapat mempengaruhi ekspresi ACE2. Penggunaan ACE-I selama pandemi menuai pro dan kontra yang memunculkan saran penggantian golongan obat antihipertensi seperti CCB. Tujuan : Mengetahui ekspresi ACE2 jaringan paru tikus setelah induksi hipertensi dan dilanjutkan dengan pemberian ACE-I (kaptopril) atau CCB (amlodipine), dan switching ACE-I menjadi CCB. Metode : Post control group design menggunakan 30 sampel tikus Sprague dawley yang dibagi menjadi 5 kelompok yaitu non-hipertensi, hipertensi, hipertensi + ACE-I, hipertensi + CCB, dan hipertensi + ACE-I switching CCB. Induksi hipertensi menggunakan L-NAME selama 6 minggu dan pengukuran tekanan darah menggunakan metode non-invasif. Pemberian obat antihipertensi diberikan selama 1 minggu. Ekspresi ACE2 diukur menggunakan ELISA kit Elabscience®. Hasil : Ekspresi ACE2 pada kelompok non hipertensi vs hipertensi tidak ditemukan perbedaan bermakna. Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan ACE-I vs CCB ditemukan lebih tinggi pada kelompok CCB (p = 0.042). Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan lebih tinggi dibanding kelompok hipertensi tanpa pengobatan (p = 0.001). Diskusi : Ekspresi ACE2 lebih tinggi pada kelompok dengan pengobatan ACE-I dengan cara menghambat efek Angiotensin II, sehingga kadar ACE2 meningkat sebagai mekanisme kompensasi. Sedangkan CCB akan meningkatkan kadar Angiotensin I dan menurunkan rasio Angiotensin (1-7)/ Angiotensin I dan menurunkan rasio ACE2/ACE Kesimpulan : Ekspresi ACE2 meningkat pada jaringan paru hipertensi dengan pengobatan ACE-I, CCB, dan switching ACE-I menjadi CCB.
The Effect of Ajwa Date Fruit Extract (Phoenix Dactylifera L.) Against Liver Damage in White Rats (Rattus Norvegicus) Induced by Meloxicam Fatimah Mappanyompa; Arsyad, M Aryadi; Sari, Dwi Kesuma; Natsir, Sartini; Cangara, Muhammad Husni; Djabir, Yulia Yusrini
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 1, JANUARY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i1.21788

Abstract

Abstract Objective: This study was aimed to investigate the protective effect of Ajwa date palm extract (Phoenix Dactylifera L.) against liver damage in white rats (Rattus norvegicus) induced by Meloxicam. Methods: The samples used in this study were twenty five male white rats divided into five groups with body weight 200 – 300gr, namely a healthy control group, negative control given Meloxicam 30mg/kgBB, treatment group 1 was given Ajwa date fruit extract 75mg/kgBW and Meloxicam 30mg/kgBW, treatment group 2 was given Ajwa date fruit extract 150mg/kgBW and Meloxicam 30mg/kgBW, and treatment group 3 was given Ajwa date fruit extract 300mg/kgBW and Meloxicam 30mg/BW for 14 days. On the 15th day, the rats were anesthetized for blood tests and euthanized for liver organ observation. Results: The result showed by giving Ajwa date palm extract with higher doses and Meloxicam 30mg/kgBW, resulted a decrease in ALT and AST enzyme levels which were close to normal values ​​in rats. Histological observation showed extensive damage to liver cell tissue, with signs of inflammation, hemorrhage, necrosis, and hydropic degeneration. By giving high doses of Ajwa date palm extract and Meloxicam 30mg/kgBW, gave a view of a decrease degree on liver tissue damage. Conclusion: The extract of Ajwa date palm (Phoenix Dactylifera L.) can provide a protective effect against liver damage in white rats (Rattus Norvegicus) induced by Meloxicam with decreased levels of liver function enzymes which are Alananine Transaminase (ALT) and Aspartate Aminotransferase (AST), along in the changes of liver histopathological view which showed a decrease degree of liver cell tissue damage. Keywords: Ajwa date palm extract; Meloxicam; Liver tissue damage.
THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET Putri, Dwi Anggara; Djabir, Yulia Yusrini; Bahar, Muhammad Akbar; Alam, Gemini; Rahman, Latifah; Aswad, Muhammad; Arsyad, Muhammad Aryadi
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.22196

Abstract

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 g/kg levonorgestrel/3.1 g/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.
SUBACUTE TOXICITY TEST OF BEACH CABBAGE [Scaevola taccada (Gaertn.) Roxb.] LEAF EXTRACT ON HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEYS OF WHITE RATS Widati, Aritzah Dwi; Adri, Tenri Ayu; Kabo, Peter; Djabir, Yulia Yusrini
Jurnal Kedokteran Hewan Vol 16, No 2 (2022): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i2.19310

Abstract

The purpose of this study was to evaluate the toxic effects of beach cabbage leaves [Scaevola taccada (Gaertn.) Roxb.]by observing the histopathological changes in the livers and kidneys of male white rats. This study used 20 white rats which were divided into 4 groups: 1 control group and 3 groups receiving treatments in the form of Scaevola taccada leaf ethanolic extract (STLEE) in graded doses (200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW). Toxicity test was performed by administering STLEE for 14 days. The results of daily observations showed that the experimental animals experienced diarrhea. Meanwhile, histopathological observations showed the occurrences of hydropic degeneration, fat degeneration, necrotic liver cells, and dilatation of Bowman's capsule in the animals kidney cells. It was concluded that STLEE at a dose of 200 mg/kg BW is safe to use, but is toxic at a dose of 600 mg/kg BW, both to the livers and kidneys.
Co-Authors Abustani, Muthiah Adri, Tenri Ayu Arsyad, M Aryadi Arsyad, Muhammad Aryadi Cangara, Husni Djaharuddin, Irawaty Dwi Kesuma Sari Fatimah Mappanyompa Gemini Alam IRFAN IDRIS Ismail, Amirah Febrianti Kasim, Hasim Latifah Rahman Muh. Akbar Bahar Muhammad Aswad Natsir, Sartini Peter Kabo Putri, Dwi Anggara Widati, Aritzah Dwi