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Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus Fathoni, Zuhrotun Ulya; Indra, Rasjad; Supranowo, Supranowo
Jurnal Kedokteran Brawijaya Vol 28, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Rosela memiliki anthocyanin sebagai antioksidan polifenol yang berpotensi mencegah progresivitas penyakit akibat stres oksidasi. Diet aterogenik dan stres oksidasi memicu serangan radikal bebas pada komponen lemak dan protein sehingga terjadi perlemakan hepar dan peningkatan ekspresi ADMA (Asymmetric dimethylarginine). Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak rosela strain Hibiscus sabdariffa terhadap perlemakan hepar dan ekspresi ADMA hepar pada tikus Rattus norvegicus yang diberi diet aterogenik. Studi eksperimental menggunakan post test only control group pada Rattus norvegicus strain Wistar jantan yang dibagi dalam empat kelompok, yaitu kelompok kontrol positif (diet aterogenik), kelompok1 (ekstrak rosela 150mg/kgBB/hari + diet aterogenik), kelompok 2 (ekstrak rosela 300mg/kgBB/hari + diet aterogenik), dan kelompok kontrol negatif (tanpa pemberian diet aterogenik dan ekstrak rosela). Hasil penelitian menunjukkan bahwa ekstrak rosela mampu menurunkan perlemakan hepar yang berdasar pemeriksaan histopatologi berupa jumlah sel yang mengalami perlemakan lebih sedikit (p=0,000). Ekspresi ADMA dari gambaran imunohistokimia menunjukkan ekspresi yang lebih sedikit pada kelompok dengan diberi ekstrak rosela (p=0,000). Dapat disimpulkan pemberian ekstrak rosela menghambat perlemakan hepar akibat diet aterogenik dan ekspresi ADMA akibat diet aterogenik pada tikus, dengan dosis optimum rosela 300 mg/kgBB/hari.Â Kata Kunci: Diet aterogenik, ekspresi ADMA hepar, perlemakan hepar, rosela

Implementasi Aspek Promotif Upaya Kesehatan Jiwa di Malang Zuhrotun Ulya
Jurnal Kebijakan Kesehatan Indonesia Vol 7, No 4 (2018)
Publisher : Center for Health Policy and Management

Mental disorders require holistic management that involves families and communities to make mental health communities. Education about mental disorders and emergency psychiatry is expected to be able to direct and foster participant activities to better recognize the importance of mental health. This research was conducted through the education as a promotive aspect of mental health involving 45 participants from various component of community which were evaluated for implementation through educational processes and results. The implementation of education on mental disorders as a promotive aspect of mental health make mindset and attitudes of society that mental disorders can be treated appropriately and as an alternative of empowering mental health communities in Malang.

STRUCTURAL FAMILY THERAPY AS MEDIATION PROCESS FOR MARITAL CONFLICT (CASE STUDY) Zuhrotun Ulya
Journal of Psychiatry Psychology and Behavioral Research Vol. 1 No. 1 (2020)
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.857 KB)

Divorce cases were dominated by marital conflict by partner disputes, miscommunication, economic problems, etc. The mediation process as one of the stages of the divorce process allows couples to discuss about their decisions. This will be followed by one of the couples come looking for help due to their psychological problems to psychiatrist or psychologist. Tracing the problem lies in the pattern of relationship structure and family intimacy that triggers marital conflict. Structural Family Therapy (SFT) is a psychotherapy modality that is expected to improve the structure of sub-system relations so that it appears as an effort to mediate marital conflict. This research will try to find out the results of Structural Family Therapy as an effort to mediate marital conflict through evaluation of the structure relationship and family intimacy.Â This research was qualitative (case study) which conduct to 3 married couples, registered as patient at Psychiatry Clinic Universitas Brawijaya Hospital, research held for 20 weeks (December 2018 - April 2019). Evaluation from structure of the family area (family structure, system flexibility, resonance, life context, level of development and transaction patterns) and family intimacy. Post SFT evaluation, there was not only increasing of structure area and family intimacy in all cases but also slightly resolve of marital conflicts. This case study need to follow up in long term evaluation after SFT.Keywords:Â structural family therapy, marital conflict, mediation.

MALADAPTIVE PARENTING AND PEER GROUP BULLYING AS PATHOLOGICAL PATHWAYS TO BORDERLINE PERSONALITY DISORDER SYMPTOMS IN EARLY ADULT: CASE REPORT Hayuning Widhihutami; Zuhrotun Ulya
Journal of Psychiatry Psychology and Behavioral Research Vol. 4 No. 2 (2023): Mental Health Awareness Approach by Understanding Literacy and Clinical Evidenc
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jppbr.2023.004.02.5

Introduction – Maladaptive experiences during adolescene have been consistently linked with borderline personality disorder. BPD is a serious mental illness characterized by pervasive pattern of instability in affect regulation, impulse control, interpersonal relationships, and self-image. Tthere was an interrelated relationship between parenting experiences and the development of BPD symptoms. Children who reported chronic bullying had a fivefold increase in the likelihood of developing BPD symptoms. Methods – Presented the case of patient, 20 years old young male with symptoms of borderline personality disorder turned out to have maladaptive parenting and history of became victim by peer group bullying since childhood. Data were taken from interviews and mental status examinations in psychiatric clinics, then a literature review was carried out. Results – The development of borderline personality disorder in adult linked with report of low care parenting, involves coldness, indifference, and rejection. BPD is also inevitable from hereditary risk factors. Discuss – There is a direct significant association between being victim of bullying and development of BPD. Empathy is one important aspect of social behavior that may not function in BPD. Atypical depressed patients with affective dysregulation first diagnosed with borderline personality disorder if do not meet the diagnostic criteria for bipolar disorder. Conclusion – Borderline personality disorder (BPD) is very prone to occur in young adults. Starting from affect dysregulation, inability to impulse control, unstable interpersonal relationships, and unstable self-image that begin to develop in children and adolescents when exposed to environmental risk factors. Risk factors that are very often influencing are family and peer group relationships. BPD is also an entry point for developing into bipolar disorder. Therefore, effective interventions should be targeted, early preventing the development of affect dysregulation in the development of the borderline personality disorder by reducing exposure to environmental risk factors. Keywords: borderline personality disorder, maladaptive parenting, bullying.

CHRONIC SMOKING AND PORNOGRAPHIC ADDICTION IN SCHIZOPHRENIA PATIENT WITH URBAN LIVING: CASE REPORT Gumilar Fardhani Ami Putra; Zain Budi Syulthoni; Zuhrotun Ulya
Journal of Psychiatry Psychology and Behavioral Research Vol. 4 No. 2 (2023): Mental Health Awareness Approach by Understanding Literacy and Clinical Evidenc
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jppbr.2023.004.02.6

Introduction – Urban living, chronic smoking is a risk factor in schizophrenia. Pornographic addiction is also a potential risk factor of schizophrenia considering its neurobiological pathways. Schizophrenia is one of the most dangerous mental illness contributing to 2,8% years lived with disability. Considering many people with urban living, chronic smoking, and pornographic consumption, relation of these risk factors to schizophrenia is demonstrated in this case report. Methods – Presented the case of the patient, 39 years old with psychotic symptoms was found to be born and lived most of his life in urban area, smoking since junior high school, and often consumed pornographic contents since senior high school. Data were taken from psychiatric interviews, general, and mental status examinations in psychiatric clinics, then a literature review was carried out. Results – People who born, and live through their live longer in a larger city, have more risk of Schizophrenia. Patient was known to be born in one of the biggest city in Indonesia, before moved out to another urban area in different countries in last two years. Crave with chronic smoking and pornographic addiction become one of contraproductive conduct source which arise difficulty in patient’s side to take an health life style with the risk of poor prognosis and mental health deterioration. Discuss – People who born and live longer in urban areas such as cities are in increased risk of schizophrenia due to social status awareness and fast paced life induce brain stress. Chronic smoking is a risk factor of schizophrenia due to the effect of nicotine on dopamine levels. Pornographic addiction is a potential risk factor due to addiction pathway effect on dopamine threshold. Conclusion – Urban living, chronic smoking, and pornographic addiction are risk factors associated with schizophrenia found in this case report. Epidemiologic and pathophysiological mechanisms behind these risk factors are an interesting view for physician dealing with schizophrenia patients. Awareness of social status and fast paced life in urban lifestyle, pathways of nicotine in dopamine dysregulation, and dopamine-related impairment in addiction are the neurobiological mechanisms behind these risk factors which a physician needs to be aware of. Keywords: schizophrenia, urban living, chronic smoking, pornographic addiction

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