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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) AloHA International Journal of Health Advancement (AIJHA) Global Health Science (GHS) Pharmaceutical Reports
Lukman La Basy
Department Of Pharmacy, STIKES Maluku Husada, West Seram, Maluku
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The effects of the ethanolic extract of mahogany seeds (Swietenia macrophylla King) on the renal function of streptozotocin-induced diabetic rats Lukman La Basy; Sri Lestari SR; Sri Kadarsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.139 KB) | DOI: 10.19106/JMedSci004702201501

Abstract

Diabetes-associated oxidative stress causes glomerular hypertrophy, decrease ofglomerular filtration rate and inhibits cell proliferation that lead to the decrease of renalfunction as indiated by the increase of serum creatinine level and the presence ofprotein in urine. Mahogany seed (Swietenia macrophylla King) has been proven to haveantidiabetic activity. This study was conducted to evaluate the effect of the ethanolicextract of mahogany seeds on the renal function of streptozotocin-induced diabetic rats.Six normal rats as control (Group I) and 24 diabetic rats were used in this study. Thediabetic rats were randomized allocated into four groups with six rats in each group.Group II was considered as diabetic rats control and received aquadest. Group III-V wereconsidered as extract administered diabetic group and received ethanolic extract of S.macrophylla seed for 21 days at a dose of 50, 100 and 200 mg/kg BW, respectively.Serum malondialdehyde (MDA), serum creatinine, and urine protein levels were monitored,before and after the ethanolic extract of S. macrophylla seed administration. Serum MDA,serum creatinine and urine protein levels of all rats after STZ induction (Group II-V) weresignificantly higher than without STZ induction (p < 0.05). A significant decrease in theserum MDA and serum creatinine as well as urine protein levels were observed after thetreatment with ethanolic extract of S. macrophylla seed compared to before treatment(p < 0.05). In conclusion, the ethanolic extract of S. macrophylla seed is able to correctrenal dysfunction of streptozotocin-induced diabetic rats.
Validation of Metamizole, Thiamin and Pyridoxine Simultaneous Analysis Methods in Tablet Preparations Using HPLC Vevi Maritha; Lukman Labasy
Aloha International Journal of Health Advancement (AIJHA) Vol 1, No 1 (2018): JULY
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha10105

Abstract

The aim of the present study was to develop and validate HPLC method for the simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Metamizole is a substance that is easily hydrolyzed in the precence of water and oxygen. To inhibit the hydrolysis of metamizole during sample preparation prior to HPLC analysis, sodium sulfite is added and its optimum concentration was investigated. The chromatographic system includes a RP C8(2) column (150x4.6 mm, 5 µm particle size) in conjunction with Photo Diode Array (PDA) detector. The optimal chromatographic condition was obtained using a mobile phase consisting of phosphate buffer 35mM pH 3.0: methanol (80:20), flowrate 1.0 ml/min, and 10 µl injection volume. The metamizole, thiamine and pyridoxine were detected at 275 nm and 361 nm for cyanocobalamin. The Hydrolysis of metamizole was successfully inhibited by adding solution containing 1.5 mg/mL sodium sulfite to solvent and 0.5 mg/mL sodium sulfite to mobile phase. The validation results indicate a good specificity and a linear detector responses with r>0.999. The accuracy (% recovery) for metamizole, thiamine and piridoxine were 100.26%; 99.09%; and 100.03%, respectively. The method yields good precision with RSD of metamizole, thiamine and pyridoxine were 2.0912%; 1.4489%; and 0.8418% respectively. In the robustness study, the small changes of mobile phase pH yielded unsymmetrical peaks and lower resolution. The validated method was successfully applied for simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Keywords: validation; metamizole; thiamine; pyridoxine; hydrolysis of metamizole; HPLC
Faktor Kejadian Congestive Heart Failure (CHF) di Ruang ICU di RSUD Masohi Kab. Maluku Tengah 2015 Lukman La Basy; Idham Soamole; Ayamu Bugis
GLOBAL HEALTH SCIENCE Vol 1 (2016): Nomor Khusus Hari Kesehatan Nasional
Publisher : Communication and Social Dinamics (CSD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/ghs.v1iHKN.310

Abstract

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Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography Mamat Pratama; Dian Harisman; Lukman Labasy; Seniwati Seniwati; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.555 KB) | DOI: 10.33096/pharm rep.v1i1.154

Abstract

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.
Co-Authors Ayamu Bugis Dian Harisman Idham Soamole Mamat Pratama Muammar Fawwaz Seniwati Seniwati Sri Kadarsih Sri Lestari SR Vevi Maritha