Article Per Year (5 Year)
p-Index From 2021 - 2026
1.037
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) AloHA International Journal of Health Advancement (AIJHA) Global Health Science (GHS) Pharmaceutical Reports Medical Laboratory Journal Jurnal Kesehatan Maluku Husada Jurnal Pengabdian Masyarakat Multidisiplin Jurnal Entitas Kesehatan
Lukman La Basy
Department Of Pharmacy, STIKES Maluku Husada, West Seram, Maluku
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

Published : 8 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 8 Documents
Search

 1 
The effects of the ethanolic extract of mahogany seeds (Swietenia macrophylla King) on the renal function of streptozotocin-induced diabetic rats Lukman La Basy; Sri Lestari SR; Sri Kadarsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.139 KB) | DOI: 10.19106/JMedSci004702201501

Abstract

Diabetes-associated oxidative stress causes glomerular hypertrophy, decrease ofglomerular filtration rate and inhibits cell proliferation that lead to the decrease of renalfunction as indiated by the increase of serum creatinine level and the presence ofprotein in urine. Mahogany seed (Swietenia macrophylla King) has been proven to haveantidiabetic activity. This study was conducted to evaluate the effect of the ethanolicextract of mahogany seeds on the renal function of streptozotocin-induced diabetic rats.Six normal rats as control (Group I) and 24 diabetic rats were used in this study. Thediabetic rats were randomized allocated into four groups with six rats in each group.Group II was considered as diabetic rats control and received aquadest. Group III-V wereconsidered as extract administered diabetic group and received ethanolic extract of S.macrophylla seed for 21 days at a dose of 50, 100 and 200 mg/kg BW, respectively.Serum malondialdehyde (MDA), serum creatinine, and urine protein levels were monitored,before and after the ethanolic extract of S. macrophylla seed administration. Serum MDA,serum creatinine and urine protein levels of all rats after STZ induction (Group II-V) weresignificantly higher than without STZ induction (p < 0.05). A significant decrease in theserum MDA and serum creatinine as well as urine protein levels were observed after thetreatment with ethanolic extract of S. macrophylla seed compared to before treatment(p < 0.05). In conclusion, the ethanolic extract of S. macrophylla seed is able to correctrenal dysfunction of streptozotocin-induced diabetic rats.
Validation of Metamizole, Thiamin and Pyridoxine Simultaneous Analysis Methods in Tablet Preparations Using HPLC Vevi Maritha; Lukman Labasy
Aloha International Journal of Health Advancement (AIJHA) Vol 1, No 1 (2018): JULY
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha10105

Abstract

The aim of the present study was to develop and validate HPLC method for the simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Metamizole is a substance that is easily hydrolyzed in the precence of water and oxygen. To inhibit the hydrolysis of metamizole during sample preparation prior to HPLC analysis, sodium sulfite is added and its optimum concentration was investigated. The chromatographic system includes a RP C8(2) column (150x4.6 mm, 5 µm particle size) in conjunction with Photo Diode Array (PDA) detector. The optimal chromatographic condition was obtained using a mobile phase consisting of phosphate buffer 35mM pH 3.0: methanol (80:20), flowrate 1.0 ml/min, and 10 µl injection volume. The metamizole, thiamine and pyridoxine were detected at 275 nm and 361 nm for cyanocobalamin. The Hydrolysis of metamizole was successfully inhibited by adding solution containing 1.5 mg/mL sodium sulfite to solvent and 0.5 mg/mL sodium sulfite to mobile phase. The validation results indicate a good specificity and a linear detector responses with r>0.999. The accuracy (% recovery) for metamizole, thiamine and piridoxine were 100.26%; 99.09%; and 100.03%, respectively. The method yields good precision with RSD of metamizole, thiamine and pyridoxine were 2.0912%; 1.4489%; and 0.8418% respectively. In the robustness study, the small changes of mobile phase pH yielded unsymmetrical peaks and lower resolution. The validated method was successfully applied for simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Keywords: validation; metamizole; thiamine; pyridoxine; hydrolysis of metamizole; HPLC
Faktor Kejadian Congestive Heart Failure (CHF) di Ruang ICU di RSUD Masohi Kab. Maluku Tengah 2015 Lukman La Basy; Idham Soamole; Ayamu Bugis
GLOBAL HEALTH SCIENCE Vol 1 (2016): Nomor Khusus Hari Kesehatan Nasional
Publisher : Communication and Social Dinamics (CSD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/ghs.v1iHKN.310

Abstract

-
Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography Mamat Pratama; Dian Harisman; Lukman Labasy; Seniwati Seniwati; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.555 KB) | DOI: 10.33096/pharm rep.v1i1.154

Abstract

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.
Uji Efektivitas Antibakteri Dengan Perbedaan Konsentrasi Ekstrak Tinta Cumi-Cumi (Loligo Sp) dan Ekstrak Rumput Laut (Eucheuma cottonii) Pada Perairan Desa Buano Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Lukman La Basy; Epi Dusra; Muhammad Azril Hardiman Mahulauw; Sahrir Sillehu; Siti Rahmawaty Tombalissa
Calory Journal Medical Laboratory Journal Vol. 1 No. 4 (2023): December : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v1i4.47

Abstract

Squid ink and seaweed have the potential to be utilized as medicines, one of which is as an antibacterial medicinal material. because it contains secondary metabolite compounds that can inhibit the growth of Streptococcus Mutans bacteria. This type of research is a laboratory experiment with the method used, namely maceration for phytochemical screening tests and agar diffusion for antibacterial effectiveness tests with concentrations used in squid ink (Loligo sp) namely 5%, 10%, 15% 20% and in seaweed (Eucheuma cottonii) 1%, 5%, 10%, 15%. The results of the research conducted on phytochemical screening tests contained secondary metabolite compounds in squid ink (Loligo sp) triterpenoids, steroids and seaweed (Eucheuma cottonii) alkaloids, flavonoids, hodroquinone phenols, and tannins. From the research conducted on the antibacterial effectiveness test of squid ink (Loligo sp) and seaweed (Eucheuma cottonii) extracts against Streptococcus mutans bacteria, namely in both samples have the effectiveness in inhibiting Streptococcus mutans bacteria, with a high inhibition of squid ink concentration of 20% by 20.5 mm, and in seaweed concentration of 15% by 23 mm. The analysis used is spss using two tests, namely the shapiro wilk test and the mann whitney test. The conclusion of the mann-whitney test results with a p-value = 0.663 indicates there is no significant difference between squid ink extract (Loligo sp) and seaweed extract (Eucheuma cottonii).
Formulasi Emulgel Ekstrak Daun Kopasanda (Chromolaena odorata L.) Menggunakan Carbopol 940 Sebagai Gelling Agent Nabila Aulia; Lukman La Basy; Ety Dusra; Dzulfikri Mewar; Maritje S.J Malisngorar
JURNAL KESEHATAN MALUKU HUSADA Vol 3, No 2 (2025): JULI-DESEMBER 2025
Publisher : STIKes Maluku Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/jkmh3205

Abstract

Daun kopasanda (Chromolaena odorata L.) mengandung flavonoid, saponin, dan tanin yang berperan sebagai antibakteri, antiinflamasi, dan antioksidan sehingga berpotensi mempercepat penyembuhan luka. Untuk meningkatkan efektivitas dan kenyamanan aplikasi topikal, ekstrak daun kopasanda diformulasikan dalam bentuk emulgel dengan Carbopol 940 sebagai gelling agent. Penelitian ini bertujuan memformulasikan ekstrak daun kopasanda menjadi emulgel serta mengetahui pengaruh variasi konsentrasi Carbopol 940 sebagai gelling agent terhadap stabilitas fisik sediaan emulgel ekstrak daun kopasanda (Chromolaena odorata L.). Metode penelitian bersifat eksperimental laboratorium. Ekstrak diperoleh melalui maserasi etanol 70%, kemudian diformulasikan menjadi emulgel dengan variasi konsentrasi Carbopol 940 (0,5%, 1%, 1,5%, dan 2%). Evaluasi mutu fisik meliputi uji organoleptik, pH, viskositas, daya sebar, dan daya lekat. Data dianalisis menggunakan uji Kruskal-Wallis. Hasil menunjukkan seluruh formula stabil secara organoleptik. Nilai pH rata-rata berada dalam rentang fisiologis kulit (F1 = 6; F2 = 5; F3 = 5; F4 = 5). Viskositas meningkat seiring kenaikan konsentrasi (F1 = 695 cps; F2 = 31.444 cps; F3 = 44.636,7 cps; F4 = 66.461,3 cps). Uji daya sebar rata-rata berkisar 6 cm (F1), 5,5 cm (F2), 5 cm (F3), hingga 4 cm (F4). Uji daya lekat menunjukkan peningkatan signifikan, dari 1,7 detik (F1), 2,6 detik (F2), 4,3 detik (F3) hingga 5,3 detik (F4). Analisis Kruskal-Wallis memperlihatkan perbedaan signifikan (p < 0,05) pada viskositas, daya sebar, pH dan daya lekat antar formula. Sehingga dapat disimpulkan bahwa ekstrak daun kopasanda dapat diformulasikan menjadi emulgel yang stabil, dengan Carbopol 940 konsentrasi 1,5% sebagai formula paling optimal.
Edukasi Kesehatan dalam Meningkatkan Pengetahuan Orang Tua Terkait Penggunaan Obat pada Balita Rahmawati Raising; Oktaviarika Dewi Hermawatiningsih; Lukman La Basy; Vevi Maritha; Yetti Hariningsih
JUPAMU: Jurnal Pengabdian Masyarakat Multidisiplin Vol. 1 No. 2: Januari 2026
Publisher : Ihsan Cahaya Pustaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66031/jupamu.v1i2.110

Abstract

Penggunaan obat pada bayi dan balita di tingkat rumah tangga masih sering tidak rasional dan berisiko menimbulkan kesalahan dosis, pemilihan obat, maupun cara pemberian, sehingga dapat berdampak pada keselamatan anak. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan orang tua tentang penggunaan obat yang tepat dan rasional pada balita melalui edukasi kesehatan terstruktur. Pengabdian dilaksanakan di Desa Kleco, Kecamatan Bendo, Kabupaten Magetan, Jawa Timur, dengan sasaran 30 orang tua yang memiliki balita usia 0–5 tahun. Metode yang digunakan adalah edukasi kesehatan partisipatif melalui ceramah interaktif, diskusi, simulasi membaca label obat, demonstrasi pengukuran dosis sirup menggunakan sendok ukur/syringe oral, serta pembagian leaflet sebagai media pengingat di rumah. Hasil kegiatan menunjukkan antusiasme tinggi dari peserta, yang tercermin dari banyaknya pertanyaan terkait penentuan dosis, penggunaan antibiotik, dan penyimpanan obat. Secara kualitatif, orang tua melaporkan peningkatan pemahaman mengenai perbedaan obat resep dan obat bebas, pentingnya mengikuti aturan pakai, menghindari penggunaan antibiotik tanpa resep, serta menyimpan obat secara aman agar tidak terjangkau anak. Kegiatan ini menyimpulkan bahwa edukasi kesehatan yang sederhana, kontekstual, dan melibatkan kader serta bidan desa berpotensi meningkatkan literasi obat orang tua balita sebagai upaya pencegahan kesalahan penggunaan obat di rumah
Peran Terapi Antihipertensi terhadap Pencegahan Kekambuhan Stroke: Tinjauan Literatur Rahmawati Raising; Oktaviarika Dewi Hermawatiningsih; Lukman La Basy
Jurnal Entitas Kesehatan Vol. 1 No. 3 (2026): AGUSTUS
Publisher : PT Mara Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64465/jek.v1i3.129

Abstract

Stroke berulang merupakan masalah klinis penting karena meningkatkan risiko disabilitas, kematian, dan beban biaya kesehatan. Hipertensi merupakan salah satu faktor risiko utama yang dapat dimodifikasi dalam pencegahan kekambuhan stroke. Kajian pustaka ini bertujuan menganalisis peran terapi antihipertensi dalam mencegah stroke berulang berdasarkan bukti ilmiah terkini. Metode yang digunakan adalah systematic literature review dengan mengacu pada panduan PRISMA. Penelusuran literatur dilakukan melalui PubMed/MEDLINE, Google Scholar, ScienceDirect, dan Cochrane Library menggunakan kata kunci terkait antihypertensive drugs, recurrent stroke, secondary stroke prevention, serta blood pressure lowering. Dari 4.291 artikel yang teridentifikasi, dilakukan penyaringan berdasarkan publikasi lima tahun terakhir, free full text, human studies, usia pasien ≥19 tahun, dan kesesuaian dengan kriteria inklusi. Sebanyak 27 artikel memenuhi kriteria dan dianalisis secara naratif. Hasil kajian menunjukkan bahwa terapi antihipertensi berperan penting dalam pencegahan sekunder stroke. Obat yang paling sering digunakan meliputi ACE inhibitor, angiotensin receptor blocker, calcium channel blocker, serta diuretik thiazide atau thiazide-like. Pada fase akut, penurunan tekanan darah perlu dilakukan secara hati-hati untuk menjaga perfusi otak. Pada fase pasca-stroke, kontrol tekanan darah jangka panjang lebih konsisten menurunkan risiko kekambuhan. Telemonitoring, self-management, edukasi, dan pendampingan perawat juga mendukung kepatuhan dan keberhasilan terapi. Temuan ini menegaskan pentingnya pengendalian hipertensi komprehensif sebagai bagian pencegahan sekunder stroke.
Co-Authors Ayamu Bugis Dian Harisman Dzulfikri Mewar Epi Dusra Ety, Dusra Mamat Pratama Maritje S.J Malisngorar Muammar Fawwaz Muhammad Azril Hardiman Mahulauw Nabila Aulia oktaviarika Dewi hermawatiningsih Rahmawati Raising Sahrir Sillehu Seniwati Seniwati Siti Rahmawaty Tombalissa Sri Kadarsih Sri Lestari SR Vevi Maritha Vevi Maritha Yetti Hariningsih