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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Pharmaceutical Reports

Mamat Pratama

Fakultas Farmasi, Universitas Muslim Indonesia, Makassar

Author-ID : 2485554

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI AKTIVITAS EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE DENGAN MENGGUNAKAN ELISA READER Sukmawati Syarif; Nurnaningsih Nurnaningsih; Mamat Pratama
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.506

Kersen leaves (Muntingia calabura L) contain metabolites such as alkaloids, anthrax, polyphenols, tannins, saponins and are rich in flavonoid components such as flavones, flavonones, flavan and biflavan which have antidiabetic activity. According to a study conducted by Apriyanti (2016), the ethanol extract of kersen (Muntingia calabura L) at a dose of 250 mg / kg BB significantly reduced blood glucose levels in male wistar rats. In this study aimed at determining IC50 ethanol extract of Muntingia calabura L as an inhibitor of α-glucosidase enzymes using ELISA reader. The method was divided into 3 category is 1 (sample extract), 2 (blank) and 3 (akarbose). Each group added 25 µL α-glucosidase solution (0.25 units / mL then measured using ELISA reader 405 nm. The results showed that the ethanol extract of kersen (Muntingia calabura L) had activity as an inhibitor of α-glucosidase enzyme with IC50 34,197 µg / mL and can be categorized as active.

EFEKTIFITAS PEMANFAATAN POTENSI SENYAWA FENOLIK KUBIS UNGU (Brassica Oleraceae var.carpitata. L) SECARA INSTRUMEN UV-VIS Mamat Pratama; Aminah Aminah; Rizky Arfanita Mas'ud
Jurnal Fitofarmaka Indonesia Vol 5, No 2 (2018): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Cabbage Purple (Brassica oleracea var. Capitata L.) is one of the genus Brasica genus that is widely available in Indonesia. Purple cabbage has many benefits because it has many content, among others, vitamins A, B, C and E, mineral potassium, calcium, phosphorus, sodium and iron, sulforafan and contain anthocyanin. The purpose of this study was to perform and determine the total phenolic content of purple cabbage (Brassica oleracea var, capitata L.). The method used in qualitative analysis is through color reaction by using specific reagent, while for quantitative analysis done by UV-Vis spectrofotometry method. For antioxidant activity test through absorbance analysis of acid error and sample absorbance from observation result on UV-Vis spectrophotometer. The results of this study contain phenolic compounds, as for the total phenolic content of methanol extracts that the purple cabbage (Brassica oleraceavar, capitata L.) Amounted to 1.9873 mgGAE/g extract.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN TOMAT BUAH (Lycopersicon esculentum Mill, var. pyriforme Alef) DAN DAUN TOMAT SAYUR (Lycopersicon esculentum Mill, var. commune Bailey) DENGAN METODE DPPH (1,1-Diphenyl-2-Picryl Hydrazil) Mamat Pratama; Muzakkir Baits; Rizky Nurul Yaqin
Jurnal Fitofarmaka Indonesia Vol 2, No 1 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Antioxidant are chemical compounds that can donate one or more electrons to free radicals, so that the free radical reaction is inhibited. Generally, the compounds that have potential as an antioxidant are flavonoids, phenolics and alkaloids. Leaves of tomato (Lycopersicon esculentum Mill.) are plants that contain alkaloid. This study aims to determine the antioxidant activity of the ethanol extract of leaves of fruit tomato (Lycopersicon esculentum Mill, var. pyriforme Alef.) and leaves of vegetable tomato (Lycopersicon esculentum Mill, var. commune Bailey.) with DPPH method (1,1-Diphenyl-2-Picryl Hydrazil). Ethanol extract is obtained by extracting the leaves of friut tomato powder (Lycopersicon esculentum Mill, var. pyriforme Alef.) and the leaves of vegetable tomato (Lycopersicon esculentum Mill, var. commune Bailey.) with maceration. Antioxidant activity was measured using a UV-Vis spectrophotometer with maximum absorption wavelength is 514 nm. Readable absorbance is used to calculate % inhibition and IC50. The results showed that the samples of the leaves of fruit tomato (Lycopersicon esculentum Mill, var. pyriforme Alef.) and leaves of vegetable tomato (Lycopersicon esculentum Mill, var. commune Bailey.) have antioxidant activity with IC50 values of each of 279.482 µg/mL and 280.190 µg/mL. This shows the ethanol extract of leaves of fruit tomato (Lycopersicon esculentum Mill, var. pyriforme Alef.) and leaves of vegetable tomato (Lycopersicon esculentum Mill, var. commune Bailey.) has a very weak activity as an antioxidant.

ANALISIS KADAR TANIN TOTAL EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum L.) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Mamat Pratama; Raiz Razak; Vivien Sandra Rosalina
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Clove flower (Syzygium aromaticum L.) contain saponins, tannins, alkaloids, glycosides and flavonoids. The research aimed to qualitatively and quantitatively determine the existence of tannins in ethanol extract of clove flower by UV-Vis Spectrophotometry. The extraction process used was maceration using ethanol of 30% with the yield value of 4.26%. The extract obtained was measured by UV-Vis Spectrophotometer at the maximum wavelength of 649.9 nm using tanic acid as the standard. The value of the measurement result of tannin content obtained in the ethanol extract of clove flower was 300.826 mg TAE/g extract or 30.0826% b/b TAE.

ANALISIS KADAR PROTEIN DAN LEMAK PADA IKAN JULUNG-JULUNG ASAP (Hemiramphus far) ASAL KECAMATAN KAYOA MALUKU UTARA DENGAN METODE KJELDAHL DAN GRAVIMETRI Mamat Pratama; Muzakkir Baits; Nurul Auliah A.R. Saman
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Content Analysis of Protein And Fats In fish smoked julung-julung (Hemiramphus far) Origin of North Maluku, Subdistrict Kayoa with Kjeldahl Method and Gravimetri Method. An investigation of analysis of protein and fat content in fish smoked julung-julung (Hemiramphus far) Origin Of North Maluku,District kayoa with kjeldahl method and gravimetri method. This study aimed to obtain scientific data about the content of protein and fat in fish smoked julung-julung (Hemiramphus far).This includes research on the protein nitrogen content of the test by Kjeldahl Method and analysis of fat content by using the method showed that the levels Gravimetri. The result showed that the samples of smoked fish fated to be unlucky-fated to unlucky (Hemiramphus far) obtained A water content of 13,90%, protein content of 71,03% and fat content 4,13% and in fish simple fated to be unlucky-fated to unlucky (Hemiramphus far) obtained B water content of 14,07%, protein content of 71,67% and fat content 5,38%.Keywords : Smoked fish julung-julung, protein, fat, kjeldahl and gravimetri.

PENETAPAN KADAR FLAVONOID FRAKSI ETIL ASETAT DAUN KARET KEBO (Ficus elastica) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Asriani Suhaenah; Mamat Pratama; A.Hesti Wulandasari Amir
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.767

Rubber plant (Ficus elastica) is a plant that has been widely used as traditional medicine. The leaves of this plant are used as medicine for coughing up blood, laxative urine, relieving pain and improving blood circulation. Various kinds of properties and benefits of the rubber plant (Ficus elastica) cannot be separated from the compounds contained in it such as saponins, polyphenols, and flavonoids. The purposes of this research is to determine the flavonoid total content in the ethyl acetate fraction of the rubber leaves (Ficus elastica). Simplicia was extracted by maceration method, using 96% ethanol solvent for 3x24 hours and partitioned with a mixture of 96% ethanol - aquadest (2:3) and ethyl acetate as a solvent. Determination of flavonoid content using UV-Vis spectrophotometry method , with a maximum wavelength of 438 nm, using quercetin as a comparison. The results of this research obtained that the total flavonoid content in the ethyl acetate fraction of rubber leaves (Ficus elastica) was an average of 74,345 mgQE/g fraction.

ANALISIS AKTIVITAS ANTIOKSIDAN SEDIAAN PROPOLIS YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE FRAP (Ferric Reducing Antioxidant Power) Mamat Pratama; A. Muflihunna; Nurazizah Octaviani
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Antioxidants are chemical compounds that can donate one or more electrons to free radical, so that free radicals that can be suppressed.This study aimed to obtain and provide scientific evidence to the public regarding the antioxidant activity in propolis liquid product circulating in Makassar. This study using FRAP (Ferric Reducing Antioxidant Power) and 96% ethanol. Free radical activity absorbance was measured with a UV-VIS spectrophotometer at a wavelength of 710 nm and the total value of antioxidant activity was calculated based on data absorbance. The calculations show that the sample A has antioxidant activity of 0.0971 mgAAE / mg sample, the sample B has antioxidant activity of 0.0669 mgAAE / mg sample, the sample C has antioxidant activity of 0.0493 mgAAE / mg samples.

ANALISIS KANDUNGAN LOGAM BERAT MERKURI (Hg) DAN TIMBAL (Pb) PADA KOSMETIK LIPSTIK YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Nurmaya Effendi; Mamat Pratama; Husna Kamaruddin
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Lipstick is a lip cosmetic that almost every day is used by the most women. Lipstick should be safe and does not contain hazardous materials as it can go ingested with food or drink consumed. One of hazardous contaminants in lipstick is contained heavy metals, such as lead and mercury. Based on these considerations, the cosmetic lipstick should be safe and do not contain harmful ingredients, One of the parameters to determine the lipstick cosmetics are safe or not from the content of the metals in contained. To determine the metals Pb and Hg contamination in cosmetics lipsticks do research by doing destruction samples and proceed with the analysis of the metal content using atomic absorption spectrophotometry. The results showedthat inallfour samplesstudiedlipstickall containmercury(Hg) levelseachwithA0.0460 µg/g, B0.0425 µg/g, C0.0345 µg/g, andD0,0431 µg/g, as wellasfor lead(Pb) levelseachwithA6.1628 µg/g, B3.5041 µg/g, C56.6496 µg/g, andD6.0324 µg/g.

Tyrosinase Inhibitor Activity Measurement of Crude and Purified Extract of Moringa Leaves (Moringa oleifera L.) Zainal Abidin; Ummu Khaeriah; Zuhrina Zuhrina; Mamat Pratama; Muzakkir Baits
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Moringa leaves is one of the plants that have antioxidant activity. The compounds that have strong antioxidant activity also have strong antityrosinase activity. Moringa leaves contain flavonoid compounds that can inhibit tyrosinase activity in the melanin formation process. This study aimed to determine tyrosinase inhibitor activity of crude and purified extract of moringa leaves (Moringa oleifera L.). Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome from the oxidation of L-tyrosine in the mechanism of melanogenesis. The crude extract obtained by use maceration extraction method and ethanol solvent, whereas the purified extract obtained by use liquid-liquid extraction method and ethyl acetate solvent. The results showed that hydroquinone has IC50 value of 18,234 μg/mL while crude extract of moringa leaves shows IC50 value of 4405,24 μg/mL and purified extract of moringa leaves shows IC50 value of 401,6228 µg/mL. Purified extract of moringa leaves more active as tyrosinase inhibitor than its crude extract but less active than hydroquinone.Keywords: Moringa leaves, Purified extract, Tyrosinase Inhibitor, UV Rays

Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography Mamat Pratama; Dian Harisman; Lukman Labasy; Seniwati Seniwati; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.

Co-Authors A. Muflihunna A. Muflihunna A.Hesti Wulandasari Amir Aminah Aminah Asriani Suhaenah Dian Harisman Fidyah Lisa Aslindah Hasnaeni Hasnaeni Husna Kamaruddin Lukman La Basy Muammar Fawwaz Muzakkir Baits Nurazizah Octaviani Nurmaya Effendi Nurnaningsih Nurnaningsih Nurul Auliah A.R. Saman Rahmawati Rahmawati Rais Razak Raiz Razak Rizky Arfanita Mas'ud Rizky Nurul Yaqin Seniwati Seniwati Sukmawati Syarif, Sukmawati Ummu Khaeriah Vivien Sandra Rosalina Zainal Abidin Zuhrina Zuhrina

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