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Epidemiological Correlation Between Her-2 Expression With Histological Type and Grade Breast Carcinoma On Oncology Department, Moewardi Hospital, Surakarta, Indonesia Dian Ibnu Wahid; Widyanti Soewoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Some woman have breast tumors with higher level of HER-2. HER-2 receptor is is a member of the epidermal growth factor receptor family which one such gene that can play a role in the development of breast carcinoma. Normally, HER-2 receptors control breast cell grows, divides, and repair breast cell. But in pathologic conditions it make too many copies. The aim of this study was to evaluated the expression of HER-2 in woman breast carcinoma and to compare it with Histological Type and Grade. We Observed 1.395 patients with breast carcinoma. The mean age of the patients was 45.7 (Ranged 23-73 years). In this group the frequency of Her2 positive was higher than other. The incidence of patients above 50 years of age were significancy higher in Her2 positive with 363 (47%). For tumor grading, the highest on G3 with the results 764 (54.7%). G3 got the highest results on Her2 positive with 535. We just divide the type of tumor consist of three parts (ductal, lobular, and other). In tumor type obtained the most data on ductal carcinoma with 878 (63%). The difference did not achieve stastitical significance , when calculated with chi square got results >0.05. From the results can be concluded there is no relationship between Her2 with histological type and grade breast cancer.

Profile of Breast Cancer Patients at Dr. Moewardi Surakarta Period March 2016 - March 2018 Randi Dwiyanto; Widyanti Soewoto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.324

Introduction: Breast cancer is a heterogeneous disease caused by the interaction of genetic factors and environmental risk factors that lead to the accumulation of progressive genetic and epigenetic changes in breast cancer cells. The incidence of breast cancer in Indonesia is 11% of all cancer incidents. There are many factors that are thought to have an influence on the occurrence of breast cancer, including age, immunohistochemistry, and variable levels of first breast carcinoma at old age. Methods: A descriptive retrospective study by taking medical record data about breast cancer at the Dr. Moewardi General Hospital, Surakarta. at the Installation of Medical Records at the General Hospital DR. Moewardi Period February 2016 - February 2018. Results: According to the age group of 50 years, 162 patients (54%) and above who had a high risk and under 50 years group were 138 patients (46%). From the results of the study, breast cancer patients with grade 3 were found to be the most with 155 cases (51.67%). Hormonal receptor detection in breast cancer patients showed a high incidence of HER-2-negative patients as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). There was a high incidence of negative HER-2 as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). Positive HER-2 subtypes (ER-, PR-, HER2 +) were the most common cases, namely 128 cases (42.67%). The magnitude of the correlation (Phi and Cramer) produces the same number, while the contingency coefficient produces a smaller number. Conclusion: There is almost no relationship or there is a very weak relationship between age, immunohistochemistry, and variable rates of breast carcinoma, variable rates of breast carcinoma at the occurrence of metastases.

Hubungan Reseptor Estrogen, Reseptor Progesteron dan Ekspresi Her-2/Neu Dengan Grading Histopatologi pada Pasien Kanker Payudara di RSUD dr. Moewardi Surakarta Warjianto Warjianto; Widyanti Soewoto; Untung Alifianto; Hari Wujoso
Smart Medical Journal Vol 3, No 2 (2020): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v3i2.35228

Pendahuluan: Kanker payudara merupakan keganasan pada wanita yang memiliki prosentasi dan angka mortalitas cukup tinggi baik di dunia maupun Indonesia. Pada kanker payudara memiliki reseptor untuk hormon estrogen, progesteron, dan protein Her–2 yang berperan dalam proses terjadinya sel kanker. Dimana keberadaan ER, PR dan Her-2/Neu serta Grading Histopatologi sangat mempengaruhi manajemen dan prognosis pada pasien dengan karsinoma payudara.Tujuan: Mengetahui hubungan antara Reseptor Estrogen, Reseptor Progesteron dan ekspresi Her-2/neu dengan grading histopatologi pada penderita wanita dengan kanker payudara.Bahan & Metode: Pasien kanker payudara sejumlah 73 orang yang berobat di Poliklinik dan dirawat di bangsal serta pengambilan sample di sub Bagian Bedah Onkologi RSUD dr. Moewardi Surakarta antara April sd Desember 2018. Pemeriksaan Immunohistokimia dan Histopatologi di bagian Patologi Anatomi RSUD dr. Moewardi Surakarta. Penelitian prospektif analitik korelasi dengan cross sectional.Kesimpulan: Tidak terdapat hubungan antara reseptor estrogen dengan grading histopatologi pada pasien kanker payudara di RSUD dr. Moewardi Surakarta Jawa Tengah (p=0,901).Tidak terdapat hubungan antara reseptor progesteron dengan grading histopatologi pada pasien kanker payudara di RSUD dr. Moewardi Surakarta Jawa Tengah ( p=0,512).Tidak terdapat hubungan antara ekspresi Her-2/neu dengan grading Histopatologi pada pasien kanker payudara di RSUD dr. Moewardi Surakarta Jawa Tengah ( p=0,629). Introduction: Breast cancer is a malignancy in women who have a high percentage and mortality rate both in the world and Indonesia. Breast cancer has receptors for the hormones estrogen, progesterone, and Her-2 protein which play a role in the process of cancer cells. Where the existence of ER, PR and Her-2 / Neu and Histopathology Grading greatly affect the management and prognosis in patients with breast carcinoma.Objective: To determine the relationship between Estrogen Receptor, Progesterone Receptor and Her-2 / neu expression with histopathological grading in women with breast cancer.Material & Methods: There were 73 breast cancer patients who were treated at the Polyclinic and treated in the ward and taking samples in the sub-section of Surgical Oncology Hospital Dr. Moewardi Surakarta between April to December 2018. Immunohistochemistry and Histopathology Examination in the Anatomy Pathology section of RSUD dr. Moewardi Surakarta. Prospective analytic correlation research with cross sectional study.Conclusion: There is no relationship between estrogen receptors with histopathological grade in breast cancer patients at dr. Moewardi Surakarta, Central Java (p = 0,901). There was no relationship between progesterone receptors and histopathological grade in breast cancer patients at dr. Moewardi Surakarta, Central Java (p = 0.512). There was no relationship between Her-2 / neu expression and histopathological grading in breast cancer patients at dr. Moewardi Surakarta, Central Java (p = 0.629)

Profile of Breast Cancer Patients at Dr. Moewardi Surakarta Period March 2016 - March 2018 Randi Dwiyanto; Widyanti Soewoto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.324

Introduction: Breast cancer is a heterogeneous disease caused by the interaction of genetic factors and environmental risk factors that lead to the accumulation of progressive genetic and epigenetic changes in breast cancer cells. The incidence of breast cancer in Indonesia is 11% of all cancer incidents. There are many factors that are thought to have an influence on the occurrence of breast cancer, including age, immunohistochemistry, and variable levels of first breast carcinoma at old age. Methods: A descriptive retrospective study by taking medical record data about breast cancer at the Dr. Moewardi General Hospital, Surakarta. at the Installation of Medical Records at the General Hospital DR. Moewardi Period February 2016 - February 2018. Results: According to the age group of 50 years, 162 patients (54%) and above who had a high risk and under 50 years group were 138 patients (46%). From the results of the study, breast cancer patients with grade 3 were found to be the most with 155 cases (51.67%). Hormonal receptor detection in breast cancer patients showed a high incidence of HER-2-negative patients as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). There was a high incidence of negative HER-2 as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). Positive HER-2 subtypes (ER-, PR-, HER2 +) were the most common cases, namely 128 cases (42.67%). The magnitude of the correlation (Phi and Cramer) produces the same number, while the contingency coefficient produces a smaller number. Conclusion: There is almost no relationship or there is a very weak relationship between age, immunohistochemistry, and variable rates of breast carcinoma, variable rates of breast carcinoma at the occurrence of metastases.

Lactating Adenoma in Pregnancy: A Case Report Satrio Sarwo Trengginas; Widyanti Soewoto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.560

Background: Lactating adenoma is a rare palpable breast lesion that occurs late in pregnancy or the lactation period and is commonly found in young primiparous women in the second or third decade of life. This case report aims to describe lactating adenoma and its management. Case presentation: A woman, 24 years old, 26 weeks pregnant, came to the Surgical Oncology Polyclinic of Dr. Moewardi Hospital Surakarta with a complaint of a lump in the right breast from the last 4 months. The lump was felt to be getting bigger, painful to the point that sometimes fluid came out of the nipple of her right breast. The patient had a history of previous lumps with a diagnosis of fibroadenoma that had been operated on. On palpation multiple nodules are palpable. Mammography examination showed a mass with partial calcification (BIRADS 3). The patient was diagnosed with a tumur of mammae dextra suspected of malignant cT2N1Mx with G1P0A0 26 weeks gestation. Histopathological examination results showed a lactating adenoma. Conclusion: There are several recommendations for the management of lactating adenoma during pregnancy. An antepartum biopsy is recommended for women with a breast mass in the first or second trimester, postpartum for masses that appear in the late third trimester, and fine-needle aspiration biopsy as an alternative for masses that appear in the early third trimester. Treatment with bromocriptine, a dopamine agonist, may be given to reduce the size of the lactating adenoma.

Lactating Adenoma in Pregnancy: A Case Report Satrio Sarwo Trengginas; Widyanti Soewoto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.560

Background: Lactating adenoma is a rare palpable breast lesion that occurs late in pregnancy or the lactation period and is commonly found in young primiparous women in the second or third decade of life. This case report aims to describe lactating adenoma and its management. Case presentation: A woman, 24 years old, 26 weeks pregnant, came to the Surgical Oncology Polyclinic of Dr. Moewardi Hospital Surakarta with a complaint of a lump in the right breast from the last 4 months. The lump was felt to be getting bigger, painful to the point that sometimes fluid came out of the nipple of her right breast. The patient had a history of previous lumps with a diagnosis of fibroadenoma that had been operated on. On palpation multiple nodules are palpable. Mammography examination showed a mass with partial calcification (BIRADS 3). The patient was diagnosed with a tumur of mammae dextra suspected of malignant cT2N1Mx with G1P0A0 26 weeks gestation. Histopathological examination results showed a lactating adenoma. Conclusion: There are several recommendations for the management of lactating adenoma during pregnancy. An antepartum biopsy is recommended for women with a breast mass in the first or second trimester, postpartum for masses that appear in the late third trimester, and fine-needle aspiration biopsy as an alternative for masses that appear in the early third trimester. Treatment with bromocriptine, a dopamine agonist, may be given to reduce the size of the lactating adenoma.

Breast cancer survivors and behavior: cancer care in the time of COVID-19 in Indonesia Widyanti Soewoto
Universa Medicina Vol. 41 No. 3 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.277-288

The COVID-19 pandemic caused significant disruptions in cancer care, and preliminary research suggests that these disruptions are associated with increased levels of psychosocial distress among cancer survivors. Indonesia initially reported positive cases in early March 2020, followed by regular extensive occurrences across 34 provinces. The disease causes acute respiratory failure among people with specific comorbidities, including geriatric disorders, diabetes, cardiovascular and respiratory diseases, and cancer. Consequently, the patients’ conditions become more severe, possibly leading to a higher mortality rate. Individuals with cancer are at particularly elevated risk of a severe course of COVID-19 because they tend to be of older age and are at a greater risk for needing intensive care and for mortality. A reasonably good comprehension of the current COVID-19 outbreak, poor awareness of the primary disease and subsequent therapy program, and minimal understanding of the importance of continuing treatment during the pandemic are the probable factors causing the fear of contracting the COVID-19 virus that poses a significant threat of aggravating the existing breast cancer conditions in most patients. This anxiety shows a drastic impact in altering the behavioral patterns of survivors undergoing therapy. There is a very good understanding of how it is caused by the SARS-COV2 virus. Meanwhile, there is a severe lack of understanding of cancer and the therapeutic program. The patients are more afraid of contracting this virus than they are of their cancer. Patients prefer development of their cancer to contracting the SARS-COV2 virus. Therefore, massive education and supervision are needed for cancer patients to understand the COVID-19 pandemic and ensure that routine checks are appropriately managed.

Pendekatan Deteksi Dini Retinoblastoma pada Anak di RSUD Moewardi Surakarta Senyum Indrakila; Muhammad Ilham Malda; Widyanti Soewoto; Joko Purnomo; Amru Sungkar; Nunik Agustriani; Abhista Rafianka Saputra
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 9 (2023): Volume 6 No 9 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i9.10799

ABSTRAK Retinoblastoma merupakan keganasan pada mata yang sering terjadi pada anak-anak dengan insiden terjadinya berkisar antara 1 dalam 14.000 sampai 1 dalam 20.000 kelahiran. Diagnosis dan penanganan retinoblastoma yang terlambat menjadi salah satu permasalahan yang dapat mengakibatkan terjadinya metastasis ke bagian ekstraokuler, kehilangan penglihatan dan kematian. Pada negara berkembang, termasuk Indonesia penyebab keterlambatan diagnosis retinoblastoma berasal dari orang tua anak yang disebabkan oleh faktor ekonomi dan ketidaktahuan pada penyakit retinoblastoma serta kewaspadaan dari gejala klinis dari retinoblastoma. Kira-kira setengah dari populasi anak yang terdiagnosis retinoblastoma meninggal, diperkirakan karena baru terdiagnosis saat stadium lanjut. Oleh sebab itu perlu dilakukan upaya untuk meningkatkan kesadaran dan kewaspadaan orang tua tentang penyakit retinoblastoma. Penanganan awal retinoblastoma melalui deteksi dini tes lihat merah untuk melihat adanya leukokoria dapat dilakukan di fasilitas layanan kesehatan yang memadai dengan alat sederhana menggunakan oftalmoskop. Kata Kunci : Retinoblastoma, Tes Lihat Merah, Deteksi Dini ABSTRACT Retinoblastoma is a common eye malignancy in children with an incidence ranging from 1 in 14,000 to 1 in 20,000 births. Delayed diagnosis and treatment of retinoblastoma is one of the problems that can lead to extraocular metastases, loss of vision, and death. In developing countries, including Indonesia, the cause of delay in the diagnosis of retinoblastoma comes from the child's parents due to economic factors and ignorance of retinoblastoma disease and awareness of clinical symptoms of retinoblastoma. Approximately half of the population of children diagnosed with retinoblastoma die, presumably because it was diagnosed at an advanced stage. Therefore, it is necessary to make efforts to increase the awareness and vigilance of parents about retinoblastoma disease. Early treatment of retinoblastoma through early detection, see red to see the presence of leukocoria can be done in adequate healthcare facilities with simple tools using an ophthalmoscope. Keywords: Retinoblastoma, Red Reflex Test, Screening

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