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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Media Medika Muda Diponegoro International Medical Journal (DIMJ)
Dwi Marliyawati
Department Of Ear, Nose Throat, Head And Neck, Faculty Of Medicine Diponegoro University
Immunology & microbiology Medicine & Pharmacology Neuroscience

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Otoacoustic emission (OAE) features in newborns at Dr. Kariadi Central Genetal Hospital, Semarang, Indonesia Rikha Liemiyah; Dwi Marliyawati; Gatot Irawan; Arsita Eka Rini; Nuniek Wulansari; Muyassaroh Muyassaroh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005401202206

Abstract

The joint committee on infant hearing (JCIH) recommends the detection and intervention of hearing impairment in newborns. Dr Kariadi Central General Hospital, Semarang, Indonesia is a referral hospital in Central Java province that has implemented an early detection program for hearing lossin newborns. Screening or early detection using otoacoustic emissions (OAE). This study aimed to find out the description of OAE in newborns at Dr. Kariadi Central General Hospital, Semarang. This research was a descriptive analytic using secondary data the OAE results on newborns with or without risk factors (FR) who are treated at Dr. Kariadi Central General Hospital, Semarang in 2020. The result of OAE pass meant that the outer hair cell (OHC) was functioning properly in both ears while refer was if the OHC in one ear or both was not functioning properly. Total 1338 newborns with and without FR whose OAE pass resulted as much as 1297 (97%) and refer 41 (3%). Most risk factors were low birth weight 331 (42%) with the results of OAE pass 312 (94.3%), and refer 19 (5.7%). In conclusion, this study shows that OAE passed in 97% of newborns.
PENGARUH PEMBERIAN POLIFENOL MADU TERHADAP MUKOSITIS ORAL AKIBAT KEMORADIASI PADA PENDERITA KANKER KEPALA DAN LEHER Dwi Marliyawati; Wiratno Wiratno; Willy Yusmawan
Media Medika Muda Vol 1, No 1 (2016)
Publisher : Faculty of Medicine Diponegoro University

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Abstract

Latar belakang: Mukositis Oral (MO) merupakan efek samping segera akibat kemoradiasi pada penderita Kanker Kepala dan Leher (KKL) yang berdampak negatif pada kualitas hidup dan efektivitas terapi kanker. Efek sitotoksik kemoradiasi mengakibatkan terbentuknya radikal bebas (ROS) yang berlebihan sehingga terjadi kerusakan DNA sel epitel mukosa oral. Polifenol madu merupakan antioksidan dan anti inflamasi yang dapat mencegah kerusakan mukosa oralan ini bertujuan untuk membuktikan pengaruh polifenol madu dalam mengurangi kejadian MO pada penderita KKL yang mendapat kemoradiasi.Metode: Penelitian randomized controlled trial (RCT) single blinded pada 38 pasien KKL yang memenuhi kriteria inklusi dan dibagi dua kelompok. Pada kelompok perlakuan mendapatkan madu, kedua kelompok mendapat vitamin C sebagai terapi suportif. Kelompok perlakuan diberikan 15 ml madu sebanyak 3 kali, yaitu 15 menit sebelum radiasi, dan 15 menit dan 6 jam setelah radiasi. Pasien dievaluasi setiap minggu untuk mengetahui onset MO dan derajat MO berdasarkan kriteria MO dari WHO. Analisis statistik onset MO menggunakan independent t-test dan derajat MO menggunakan Kolmogorov-Smirnov Test.Hasil: Rata-rata onset MO pada kelompok perlakuan terjadi pada hari ke-11 sampai 19 dan pada kelompok kontrol pada hari ke-6 sampai 12, terdapat perbedaan yang bermakna (p=0,000). Kejadian mukositis berat pada kelompok perlakuan (26,3%) lebih sedikit daripada kontrol (63,2%) dan didapatkan perbedaan yang bermakna (p=0,001). Kelompok usia muda berpengaruh terhadap onset MO yang lambat (p=0,039; OR 7; 95%CI 1,18–41,54).Simpulan: pemberian polifenol madu dapat memperlambat onset MO dan dapat menurunkan derajat MO.Kata kunci: onset mukositis oral, derajat mukositis oral, Kanker Kepala dan Leher, polifenol madu.
Obstructive Sleep Apnea Syndrome (OSAS) Decrease Concentration Levels in Young Adults Fidela Hanan Zivana; Neni Susilaningsih; Dwi Marliyawati; Kanti Yunika
Diponegoro International Medical Journal Vol 1, No 2 (2020): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i2.9543

Abstract

Background: Obstructive Sleep Apnea Syndrome (OSAS) is sleeping-disorder that’s characterized by recurrent episodes of upper airway obstruction during sleep. Fourteen percent of world populations suffer from OSAS. OSA patients are 7.5 to 20 times more likely to have difficulties with concentration, learning new tasks, and execution of monotonous tasks.Objective: The primary objective of this study was to investigate the relationship between Obstructive Sleep Apnea Syndrome (OSAS) and concentration level in young adultsMethods: This is an analytic observational study with cross-sectional design. Sampling was carried out with total sampling. Samples that qualified the inclusion and exclusion criteria were assessed by OSAS using the Epworth Sleepiness Scale (ESS) questionnaire and Digit Symbol Substitution Test was used to assess the concentration level. The data were analyzed, using the chi-square test and the prevalence (PR) testResults: The Chi-square test showed that there was a significant relationship between OSAS and concentration level (p=0.033). The Prevalence Ratio test found that OSAS decreased concentration level by 1.55 compared to not OSASConclusion: There was a significant relationship between OSAS and concentration level in young adults. OSAS patients are 1.55 more likely to have a decrease concentration level when compared with healthy individuals
The Correlation of Allergic Rhinitis with Obstructive Sleep Apnea Syndrome (OSAS) in Young Adults Megawati Sianturi; Dwi Marliyawati; Willy Yusmawan; Kanti Yunika
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7930

Abstract

Background: Obstructive Sleep Apnea Syndrome (OSAS) is a breathing disorder during sleep that can cause stopping breathing and trigger dangerous diseases. The main symptoms that can occur in OSAS patients are loud snoring and excessive daytime sleepiness so it can disrupt the quality of life and performance. Allergic rhinitis (AR) is one of the risk factors for OSAS, after age, obesity, sex, neck circumference, and anatomic abnormalities of the airway. Allergic rhinitis can disrupt the quality of sleep patients. Allergic rhinitis patient has a risk of OSAS due to obstruction of the upper airways so airflow to the lungs is obstructed.Objective: To analyze the relationship of allergic rhinitis with the incidence of Obstructive Sleep Apnea Syndrome (OSAS) in young adults.Methods: This study is an observational study with a cross-sectional design. Samples were obtained with a probability sampling method by consecutive sampling. The subject of this study were students of the Faculty of Medicine, Diponegoro University, aged 18-23 years. This study consisted of interviews, BMI examination, neck circumference examination, nose, and throat examination, fill the Epworth Sleepiness Scale (ESS) questionnaire to assess OSAS and the Score For Allergic Rhinitis (SFAR) questionnaire to assess allergic rhinitis. Statistical tests use chi-square, fisher's exact test, and logistic regression.Results: The incidence of allergic rhinitis with OSAS in young adults occurred as much as 79,7%. Bivariate analyze showed allergic rhinitis associated significantly with the incidence of OSAS in young adults (p=0,000; PR=12,3). The most common group of allergic rhinitis symptoms in allergic rhinitis patients with OSAS is the group of symptoms of sneezing, rhinorrhea, and nasal congestion.Conclusion: Allergic rhinitis patients risk 12,3 times more likely to suffer from OSAS than non-allergic rhinitis in young adults.
Co-Authors Arsita Eka Rini Fidela Hanan Zivana Gatot Irawan Kanti Yunika Megawati Sianturi Muyassaroh Muyassaroh Neni Susilaningsih Nuniek Wulansari Rikha Liemiyah Willy Yusmawan Wiratno Wiratno