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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Community Empowerment for Health Indonesian Journal of Biomedicine and Clinical Sciences
Dyah Wulan Anggrahini
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Public Health And Nursing Universitas Gadjah Mada – Dr. Sardjito Hospital, Yogyakarta, Indonesi
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Tekanan darah sistolik, indeks kardiak dan sindrome Eisenmenger merupakan prediktor kematian pada pasien hipertensi arteri pulmonal terkait penyakit jantung bawaan: analisis dari register COHARD-PH Rochmat, Muflihatul Baroroh; Setianto, Budi Yuli; Anggrahini, Dyah Wulan; Dinarti, Lucia Kris; Hartopo, Anggoro Budi
Jurnal Kardiologi Indonesia Vol 45 No 3 (2024): July - September, 2024
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1623

Abstract

Background: Pulmonary arterial hypertension (PAH) is a complication of left-to-right intracardiac shunt congenital heart disease (LtR-shunt CHD). There are several known predictors of mortality in PAH patients, however predictors of mortality in LtR-shunt CHD-associated PAH need to be validated. Objectives: We aimed to investigate the predictors of mortality among adult LtR-shunt CHD-associated PAH patients. Methods: This research was a retrospective cohort study that included adult patients with LtR-shunt CHD-associated PAH retrieved from the COHARD-PH registry. Several baseline variables were selected as potential predictors of mortality, namely (1) clinical data: WHO-functional class, SaO2, 6-min walking distance, systolic blood pressure, and Eisenmenger syndrome; (2) laboratory data: hemoglobin and NT-pro BNP levels; (3) echocardiography data: pericardial effusion, defect size, and TAPSE; and (4) hemodynamic data: right atrial pressure, cardiac output and index, SvO2, and flow ratio. The mortality outcome was assessed from the cohort registry. Results: A total of 124 subjects with LtR-shunt CHD-associated PAH were included. Sixteen subjects (12.9%) died during the follow-up period. The baseline variables which showed significant association with mortality were lower systolic blood pressure, Eisenmenger syndrome, higher NT-pro BNP level, and lower cardiac output. The multivariable analysis showed that systolic blood pressure <100 mmHg (OR 10.99; 95% CI 2.54-47.51, p=0.001), cardiac index <2.5 L/min/m2 (OR 8.13; 95% CI: 1.59-42.28, p=0.011) and Eisenmenger syndrome (OR 3.87; 95%CI: 1.06-14.07) were the independent predictors for mortality. Conclusions: The systolic blood pressure <100 mmHg, cardiac index <2.5 L/min/m2, and Eisenmenger syndrome were independent predictors of mortality among adults with LtR-shunt CHD-associated PAH.
Familial atrial septal defect: a case report in Indonesia Muhammad Gahan Satwiko; Lucia Kris Dinarti; Armalya Pritazahra; Abdul Majid Halim Wiradhika; Muhammad Reyhan Hadwiono; Dyah Wulan Anggrahini; Anggoro Budi Hartopo
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20213

Abstract

Familial atrial septal defect (ASD) is defined as the occurrence of ASD in the first-degree family of the ASD patient. Recently, familial ASD has been increasingly studied. Familial ASD could manifest as an isolated ASD or with other abnormalities. Furthermore, because ASD is usually asymptomatic, it is very difficult to recognize ASD in a first-degree family based only on symptoms. However, if the family was screened using electrocardiography or echocardiography, the occurrence of familial ASD could be found. Therefore, screening plays an important role in detecting familial ASD. We reported an ASD patient with several occurrences of familial ASD. ABSTRAK Atrial septal defect (ASD) familial didefinisikan sebagai terjadinya ASD di keluarga tingkat pertama pada pasien ASD. Studi mengenai ASD familial saat ini telah semakin banyak dilakukan. ASD familial dapat bermanifestasi sebagai ASD yang terisolasi ataupun ASD yang disertai dengan abnormalitas yang lain. Selain itu, karena ASD biasanya asimptomatik, sangat sulit mengenali ASD pada keluarga tingkat pertama hanya berdasarkan gejalanya. Meski demikian, jika keluarga tersebut diperiksa menggunakan elektrokardiografi atau ekokardiografi maka dapat ditemukan terjadinya ASD familial. Oleh karena itu, skrining memegang peranan penting dalam deteksi ASD familial. Kami melaporkan pasien ASD dengan beberapa kejadian ASD familial.
Co-Authors Abdul Majid Halim Wiradhika Abdul Majid Halim Wiradhika Abdus Samik Wahab Ahmad Hamim Sadewa Aisyah Ratna Yuniarti Alifia Salsabila Anggia Endah Satuti Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Anggoro Budi Hartopo Armalya Pritazahra Armalya Pritazahra Azhafid Nashar Bambang Budi Siswanto Bambang Irawan Budi Yuli Setianto Citra Dewi Wahyu Fitria Detty Siti Nurdiati Diah Saraswati Eko Budiono Erika Maharani Erna Ashlihah Rochmat Evita Devi Noor Rahmawati Fika Humaeda Assilmi Firandi Saputra Gharini, Putrika Prastuti Ratna Hariadi Hariawan Hasanah Mumpuni Hendry Purnasidha Bagaswoto Ika Trisnawati Ira Puspitawati Krisdinarti, Lucia Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Krisdinarti Lucia Krisdinarti Maemonah, Maemonah Megawati Abubakar Muhammad Gahan Satwiko Muhammad Gahan Satwiko Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Ni Made Elva Mayasari Noriaki Emoto Nu Pravitasari Putri, Naila Vinidya Rochmat, Muflihatul Baroroh Setyawati Setyawati Vera Dewanto Vera Dewanto Vienna Rosalinda Windhi Dwijanarko