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All Journal Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal)
Siti Lintang Kawuryan
Lab. SMF Ilmu Kesehatan Anak FK Unibraw/ RSU Dr Saiful Anwar Malang
Medicine & Pharmacology Neuroscience

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THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS Wibowo, Agung Prasetyo; Sujuti, Hidayat; Rahayu, Masruroh; Muid, Masdar; Kawuryan, Siti Lintang
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.222 KB) | DOI: 10.21776/ub.mnj.2018.004.02.2

Abstract

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-α, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-α and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines.Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-α and IL-6 serum were measured by ELISA.Results. TNF-α and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-α and IL-6 in SE group (R 2 = 0.841 and p = 0.0001).Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-α serum level.
TNF-α AND INTERLEUKIN-6 LEVELS IN CLINICAL EARLY ONSET NEONATAL SEPSIS TOWARD ACUTE LIVER INJURY Dinarshanty, Diani; AS, Noorhamdani; Kawuryan, Siti Lintang; Wibowo, Satrio
Jurnal Kedokteran Brawijaya Vol 29, No. 3 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.03.6

Abstract

TNF-? and IL-6 level have an important role in acute liver injury during early onset neonatal sepsis. This study aims to investigate the correlation of TNF-? and IL-6 levels in neonates with clinical early onset neonatal sepsis toward the occurrence of acute liver injury 44 neonates with clinical early onset neonatal sepsis based on SIRS criteria and Rodwell hematologic scored ?3 were included in this study. Acute liver injury is defined as elevated of AST, ALT, or AST: ALT ratio <1. TNF-? and IL-6 levels were measured using ELISA methods. This study showed that TNF-? correlated significantly with AST level (p<0,001, r=0,570), ALT level (p<0,001, r=0,554), and AST: ALT ratio (p<0,001, r=0,652). This study also showed that IL-6 correlated significantly with AST level (p<0,001, r=0,523), ALT level (p<0,001, r=0,482), AST: ALT ratio (p<0,001, r=0,603). Regression test using backward methods showed that TNF-? influence acute liver injury (indicated by AST, ALT, and AST: ALT ratio) more than IL-6. We concluded that TNF-? and IL-6 level in clinical early onset neonatal sepsis correlated with acute liver injury, whereas early onset neonatal sepsis was correlated with acute liver injury.Keywords: Acute liver injury, clinical early neonatal sepsis, IL-6 level, TNF-? level
PENGARUH KADAR TROMBOSIT, HEMATOKRIT, HEMOGLOBIN DARAH DAN PROTEIN URIN PADA IBU PREEKLAMSI /EKLAMSI TERHADAP NILAI APGAR BAYI YANG DILAHIRKAN Kawuryan, Siti Lintang
Jurnal Kedokteran Brawijaya Vol 20, No 2 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.214 KB) | DOI: 10.21776/ub.jkb.2004.020.02.6

Abstract

ABSTRACT Preclapmsi or eclampsia is one of the risk factor for asfiksia on newborn that can predicted by lower Apgar score. The aim of this research  is  to  know  the  influence  of  the  trombocyte,  hematokrit,  hemoglobin,  and  urinary  protein  examination  of  preclampsi  or eclampsi mother to baby’s Apgar score. This research was a diskriptive-cross sectional retrospective study with Chi- square test, Fisher test x2 for trend statistic analysis. Total sample was 100 which choosen by simple random sampling. The parameter of this study was trombocyte, hematokrit, hemoglobin, and urinary protein examination of preclampsi or eclampsi mother and baby’s Apgar score. There was a significant influence relationship between the raise of blood hematocrit (p=0,0243), the decrease of the blood trombocyte (p= 0,0175) and the high level of proteinuria (p=0,0154) of preclampsi or eclampsi mother  to baby’s Apgar score. In the other hand, hemoglobin (p =0,3589), SGOT (p=0,5447),SGPT (p= 0,4850), Ureum (p = 0,1964), kreatinin (p= 0,3415) level was not significantly influence. The conclusion of this reseach is hematokrit ≥ 38 % and urinary protein ≥ 4+ on preclampsi or eclampsi mother are usefull for predicting lower Apgar score of the neonate with relative risk 7,609. Keyword: preclampsi or eclampsi, trombocyte, hematokrit, hemoglobin, and urinary protein examination, Agar score
Co-Authors Agung Prasetyo Wibowo Dinarshanty, Diani Hidayat Sujuti Masdar Muid Masruroh Rahayu, Masruroh Noorhamdani AS Satrio Wibowo